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Protein

Portal protein

Gene

ORF43

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocates the viral DNA, termed terminase.UniRule annotation

GO - Biological processi

Keywordsi

Biological processViral genome packaging, Viral release from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Portal proteinUniRule annotation
Gene namesi
Name:ORF43
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

F5HGK9:
  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004237611 – 605Portal proteinAdd BLAST605

Interactioni

Subunit structurei

Homododecamerizes. Interacts with terminase subunits TRM1 and TRM3.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae portal protein family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

OrthoDBiVOG0900002I.

Family and domain databases

HAMAPiMF_04012. HSV_PORTL. 1 hit.
InterProiView protein in InterPro
IPR002660. Herpes_Portal.
PfamiView protein in Pfam
PF01763. Herpes_UL6. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HGK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRMNPGLGS SISVHPSELS ISLFEILQGK YSYVRGQTLH CSLRNPGVFF
60 70 80 90 100
RQLFIHLYKN ALANCSYDHV LSDWRTYESS AKTRWPEKEA QWGSYRRSTF
110 120 130 140 150
DSWAQTMRMT LDHLLLNAIN RVLYAKTQLS YERYVDWVVT VGMVPVVKHT
160 170 180 190 200
PDHKLVNSIQ EQLMKDCQRL ASGEKTIGRI LTSVTQEISN LVSSLSALYI
210 220 230 240 250
PGYSEVSIDY DCVKNTFVGL YKQKRVHVEV ITMPAILAGR VIFDSPIQRM
260 270 280 290 300
YTSIMSCHRT AEHAKLCQLL NTAPTKALVG SACNNVYKDI MTHLEQASQR
310 320 330 340 350
TDPKRELLNL LMKLAENKTV SGVTDVVEDF VTDVSQNIVD KNKLFGTGQE
360 370 380 390 400
TTTQGLRRQV SNSVFKCLTN QINEQFDTIT QLEKERELCM KRLKCIETQL
410 420 430 440 450
SHQQPGDAKG PGSVNLLTAN TFQSLGRLQD PSLQLTSSHI PSGSAVLNSF
460 470 480 490 500
FSSYIPPVRE SMKDLTNLWE SEMFQTYKLA PVVDNQGQRL SVTYSQDTIS
510 520 530 540 550
ILLGPFTYVI ADLLQMELIS HSFVSSSLQD IAAYLYQTSR LFVYITDVGQ
560 570 580 590 600
KYCLVTPPFE NVPGKGPGET DWSANEYSCP EDSRVRRGLS RIPPPCGAPP

CPGSA
Length:605
Mass (Da):68,014
Last modified:June 28, 2011 - v1
Checksum:i5AE7010A4C7646AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28893.1.
RefSeqiYP_001129395.1. NC_009333.1.

Genome annotation databases

GeneIDi4961497.
KEGGivg:4961497.

Similar proteinsi

Entry informationi

Entry nameiPORTL_HHV8P
AccessioniPrimary (citable) accession number: F5HGK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families