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Protein

Apoptosis inhibitor UL38

Gene

UL38

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of host apoptosis to facilitate efficient viral replication. Promotes stabilization and inactivation of host TP53 through interaction with host MDM2 (By similarity). Induces host mTORC1 activation by antagonizing the ability of host TSC1/2 to negatively regulate mTORC1. Thus, inhibits a growth regulatory pathway to facilitate viral replication.By similarity3 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Modulation of host cell apoptosis by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis inhibitor UL38
Gene namesi
Name:UL38
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004178451 – 331Apoptosis inhibitor UL38Add BLAST331

Interactioni

Subunit structurei

Interacts with host MDM2; this interaction leads to the stabilization of host TP53 (By similarity). Interacts with host TSC2; this interaction prevents host cell stress responses.By similarity1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 5Poly-Thr4
Compositional biasi275 – 278Poly-Ala4
Compositional biasi328 – 331Poly-Val4

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000CC.

Family and domain databases

InterProiView protein in InterPro
IPR003360. US22-like.
PfamiView protein in Pfam
PF02393. US22. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HG98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTTHSTAA IMSLLDEAEW RQTQMDVGGL IQASALGKVA LRYAVRKLMK
60 70 80 90 100
RGARLRHDSG LYVCICDPSY EFLQMNLSKI SWLERHCPPL DQELIMFGVI
110 120 130 140 150
EAWEEASVRP TRQLVLFMTP KWDVFAYDSG ILFFLAPSMA QFWHGAIVLE
160 170 180 190 200
YWNALFPVEV RSHVRQHAHT MDDLVMVFHQ LDYEKQVLEA RRDKNTEGPR
210 220 230 240 250
TFAKSVNSYV RAILESERRI REGKIPMTFV DRDSLRANSL AHIQATGAQP
260 270 280 290 300
SHAPAQRVLS APPSLPSPVS EEDPAAAATP PSSAATTPPS SVVPASVESE
310 320 330
LSSSPPLPPV VVKDVMYTAG EGDVVQMVVV V
Length:331
Mass (Da):36,753
Last modified:June 28, 2011 - v1
Checksum:i533D3F344DDBBB54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31603.1.
RefSeqiYP_081497.1. NC_006273.2.

Genome annotation databases

GeneIDi3077531.
KEGGivg:3077531.

Similar proteinsi

Entry informationi

Entry nameiUL38_HCMVM
AccessioniPrimary (citable) accession number: F5HG98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: June 28, 2011
Last modified: March 15, 2017
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families