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F5HG51

- PRIM_HCMVM

UniProt

F5HG51 - PRIM_HCMVM

Protein

DNA primase UL70

Gene

UL70

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 12 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The UL70 subunit bears the primase activity By similarity.By similarity

    GO - Molecular functioni

    1. DNA primase activity Source: InterPro

    GO - Biological processi

    1. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    DNA replication, Host-virus interaction

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA primase UL70 (EC:2.7.7.-)
    Gene namesi
    Name:UL70
    OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
    Taxonomic identifieri295027 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000000938: Genome

    Subcellular locationi

    Host nucleus By similarity

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 946946DNA primase UL70PRO_0000416450Add
    BLAST

    Interactioni

    Subunit structurei

    Associates with the helicase-primase complex composed of the primase UL70, the helicase UL105 and the primase-associated factor UL102. Interacts with host SNAPIN By similarity.By similarity

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi585 – 5884Poly-Asp

    Sequence similaritiesi

    Belongs to the herpesviridae UL52 family.Curated

    Family and domain databases

    InterProiIPR004340. DNA_primase_UL52/UL70_Herpvir.
    [Graphical view]
    PfamiPF03121. Herpes_UL52. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5HG51-1 [UniParc]FASTAAdd to Basket

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    MTLVLFATEY DSAHIVANVL SQTPTDHCVF PLLVKHQVSR RVYFCLQTQK    50
    CSDSRRVAPV FAVNNETLQL SRYLAARQPI PLSALIASLD EAETRPLYRH 100
    LFRTPVLSPE HGGEVREFKH LVYFHHAAVL RHLNQVFLCP TSPSWFISVF 150
    GHTEGQVLLT MAYYLFEGQY STISTVEEYV RSFCTRDLGT IIPTHASMGE 200
    FARLLLGSPF RQRVSAFVAY AVARNRRDYT ELEQVDTQIN AFRERARLPD 250
    TVCVHYVYLA YRTALARARL LEYRRVVAYD ADAAPEAQCT REPGFLGRRL 300
    STELLDVMQK YFSLDNFLHD YVETHLLRLD ESPHSATSPH GLGLAGYGGR 350
    IDGTHLAGFF GTSTQLARQL ERINTLSESV FSPLERSLSG LLRLCASLRT 400
    AQTYTTGTLT RYSQRRYLLP EPALAPLLER PLPVYRVHLP NDQHVFCAVA 450
    SETWHRSLFP RDLLRHVPDS RFSDEALTET VWLHDDDVAS TSPETQFYYT 500
    RHEVFNERLP VFNFVADFDL RLRDGVSGLA RHTVFELCRG LRRVWMTVWA 550
    SLFGYTHPDR HPVYFFKSAC PPNSVPVDAA GAPFDDDDYL DYRDERDTEE 600
    DEDGKEDKNN VPGNGVFQKT TSSVDTSPPY CRCKGKLGLR IITPFPACTI 650
    AVHPSVLRAV AQVLNHAVCL DAELHTLLDP ISHPESSLDT GIYHHGRSVR 700
    LPYMYKMDQD DGYFMHRRLL PLFIVPDAYR EHPLGFVRAQ LDLRNLLHHH 750
    PPHDLPALPL SPPPRVILSV RDKICPSTEA NFIETRSLNV TRYRRRGLTE 800
    VLAYHLYGGD GATAAAISDT DLQRLVVTRV WPPLLEHLTQ HYEPHVSEQF 850
    TAPHVLLFQP HGACCVAVKR RDGARTRDFR CLNYTHRNPQ ETVQVFIDLR 900
    TEHSYALWAS LWSRCFTKKC HSNAKNVHIS IKIRPPDAPM PPATAV 946
    Length:946
    Mass (Da):107,842
    Last modified:June 28, 2011 - v1
    Checksum:i0818168F70714FAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY446894 Genomic DNA. Translation: AAR31624.1.
    RefSeqiYP_081518.1. NC_006273.2.

    Genome annotation databases

    GeneIDi3077484.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY446894 Genomic DNA. Translation: AAR31624.1 .
    RefSeqi YP_081518.1. NC_006273.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3077484.

    Family and domain databases

    InterProi IPR004340. DNA_primase_UL52/UL70_Herpvir.
    [Graphical view ]
    Pfami PF03121. Herpes_UL52. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPRIM_HCMVM
    AccessioniPrimary (citable) accession number: F5HG51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2012
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 12 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3