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F5HG51 (PRIM_HCMVM) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA primase UL70

EC=2.7.7.-
Gene names
Name:UL70
OrganismHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) [Reference proteome]
Taxonomic identifier295027 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length946 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The UL70 subunit bears the primase activity By similarity.

Subunit structure

Associates with the helicase-primase complex composed of the primase UL70, the helicase UL105 and the primase-associated factor UL102. Interacts with host SNAPIN By similarity.

Subcellular location

Host nucleus By similarity.

Sequence similarities

Belongs to the herpesviridae UL52 family.

Ontologies

Keywords
   Biological processDNA replication
Host-virus interaction
   Cellular componentHost nucleus
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processviral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA primase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 946946DNA primase UL70
PRO_0000416450

Regions

Compositional bias585 – 5884Poly-Asp

Sequences

Sequence LengthMass (Da)Tools
F5HG51 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 0818168F70714FAC

FASTA946107,842
        10         20         30         40         50         60 
MTLVLFATEY DSAHIVANVL SQTPTDHCVF PLLVKHQVSR RVYFCLQTQK CSDSRRVAPV 

        70         80         90        100        110        120 
FAVNNETLQL SRYLAARQPI PLSALIASLD EAETRPLYRH LFRTPVLSPE HGGEVREFKH 

       130        140        150        160        170        180 
LVYFHHAAVL RHLNQVFLCP TSPSWFISVF GHTEGQVLLT MAYYLFEGQY STISTVEEYV 

       190        200        210        220        230        240 
RSFCTRDLGT IIPTHASMGE FARLLLGSPF RQRVSAFVAY AVARNRRDYT ELEQVDTQIN 

       250        260        270        280        290        300 
AFRERARLPD TVCVHYVYLA YRTALARARL LEYRRVVAYD ADAAPEAQCT REPGFLGRRL 

       310        320        330        340        350        360 
STELLDVMQK YFSLDNFLHD YVETHLLRLD ESPHSATSPH GLGLAGYGGR IDGTHLAGFF 

       370        380        390        400        410        420 
GTSTQLARQL ERINTLSESV FSPLERSLSG LLRLCASLRT AQTYTTGTLT RYSQRRYLLP 

       430        440        450        460        470        480 
EPALAPLLER PLPVYRVHLP NDQHVFCAVA SETWHRSLFP RDLLRHVPDS RFSDEALTET 

       490        500        510        520        530        540 
VWLHDDDVAS TSPETQFYYT RHEVFNERLP VFNFVADFDL RLRDGVSGLA RHTVFELCRG 

       550        560        570        580        590        600 
LRRVWMTVWA SLFGYTHPDR HPVYFFKSAC PPNSVPVDAA GAPFDDDDYL DYRDERDTEE 

       610        620        630        640        650        660 
DEDGKEDKNN VPGNGVFQKT TSSVDTSPPY CRCKGKLGLR IITPFPACTI AVHPSVLRAV 

       670        680        690        700        710        720 
AQVLNHAVCL DAELHTLLDP ISHPESSLDT GIYHHGRSVR LPYMYKMDQD DGYFMHRRLL 

       730        740        750        760        770        780 
PLFIVPDAYR EHPLGFVRAQ LDLRNLLHHH PPHDLPALPL SPPPRVILSV RDKICPSTEA 

       790        800        810        820        830        840 
NFIETRSLNV TRYRRRGLTE VLAYHLYGGD GATAAAISDT DLQRLVVTRV WPPLLEHLTQ 

       850        860        870        880        890        900 
HYEPHVSEQF TAPHVLLFQP HGACCVAVKR RDGARTRDFR CLNYTHRNPQ ETVQVFIDLR 

       910        920        930        940 
TEHSYALWAS LWSRCFTKKC HSNAKNVHIS IKIRPPDAPM PPATAV 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY446894 Genomic DNA. Translation: AAR31624.1.
RefSeqYP_081518.1. NC_006273.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3077484.

Family and domain databases

InterProIPR004340. DNA_primase_UL52/UL70_Herpvir.
[Graphical view]
PfamPF03121. Herpes_UL52. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePRIM_HCMVM
AccessionPrimary (citable) accession number: F5HG51
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families