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F5HG51

- PRIM_HCMVM

UniProt

F5HG51 - PRIM_HCMVM

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Protein

DNA primase UL70

Gene
UL70
Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The UL70 subunit bears the primase activity By similarity.

GO - Molecular functioni

  1. DNA primase activity Source: InterPro

GO - Biological processi

  1. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

DNA replication, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
DNA primase UL70 (EC:2.7.7.-)
Gene namesi
Name:UL70
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000938: Genome

Subcellular locationi

Host nucleus By similarity

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 946946DNA primase UL70PRO_0000416450Add
BLAST

Interactioni

Subunit structurei

Associates with the helicase-primase complex composed of the primase UL70, the helicase UL105 and the primase-associated factor UL102. Interacts with host SNAPIN By similarity.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi585 – 5884Poly-Asp

Sequence similaritiesi

Family and domain databases

InterProiIPR004340. DNA_primase_UL52/UL70_Herpvir.
[Graphical view]
PfamiPF03121. Herpes_UL52. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5HG51-1 [UniParc]FASTAAdd to Basket

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MTLVLFATEY DSAHIVANVL SQTPTDHCVF PLLVKHQVSR RVYFCLQTQK    50
CSDSRRVAPV FAVNNETLQL SRYLAARQPI PLSALIASLD EAETRPLYRH 100
LFRTPVLSPE HGGEVREFKH LVYFHHAAVL RHLNQVFLCP TSPSWFISVF 150
GHTEGQVLLT MAYYLFEGQY STISTVEEYV RSFCTRDLGT IIPTHASMGE 200
FARLLLGSPF RQRVSAFVAY AVARNRRDYT ELEQVDTQIN AFRERARLPD 250
TVCVHYVYLA YRTALARARL LEYRRVVAYD ADAAPEAQCT REPGFLGRRL 300
STELLDVMQK YFSLDNFLHD YVETHLLRLD ESPHSATSPH GLGLAGYGGR 350
IDGTHLAGFF GTSTQLARQL ERINTLSESV FSPLERSLSG LLRLCASLRT 400
AQTYTTGTLT RYSQRRYLLP EPALAPLLER PLPVYRVHLP NDQHVFCAVA 450
SETWHRSLFP RDLLRHVPDS RFSDEALTET VWLHDDDVAS TSPETQFYYT 500
RHEVFNERLP VFNFVADFDL RLRDGVSGLA RHTVFELCRG LRRVWMTVWA 550
SLFGYTHPDR HPVYFFKSAC PPNSVPVDAA GAPFDDDDYL DYRDERDTEE 600
DEDGKEDKNN VPGNGVFQKT TSSVDTSPPY CRCKGKLGLR IITPFPACTI 650
AVHPSVLRAV AQVLNHAVCL DAELHTLLDP ISHPESSLDT GIYHHGRSVR 700
LPYMYKMDQD DGYFMHRRLL PLFIVPDAYR EHPLGFVRAQ LDLRNLLHHH 750
PPHDLPALPL SPPPRVILSV RDKICPSTEA NFIETRSLNV TRYRRRGLTE 800
VLAYHLYGGD GATAAAISDT DLQRLVVTRV WPPLLEHLTQ HYEPHVSEQF 850
TAPHVLLFQP HGACCVAVKR RDGARTRDFR CLNYTHRNPQ ETVQVFIDLR 900
TEHSYALWAS LWSRCFTKKC HSNAKNVHIS IKIRPPDAPM PPATAV 946
Length:946
Mass (Da):107,842
Last modified:June 28, 2011 - v1
Checksum:i0818168F70714FAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY446894 Genomic DNA. Translation: AAR31624.1.
RefSeqiYP_081518.1. NC_006273.2.

Genome annotation databases

GeneIDi3077484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY446894 Genomic DNA. Translation: AAR31624.1 .
RefSeqi YP_081518.1. NC_006273.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3077484.

Family and domain databases

InterProi IPR004340. DNA_primase_UL52/UL70_Herpvir.
[Graphical view ]
Pfami PF03121. Herpes_UL52. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPRIM_HCMVM
AccessioniPrimary (citable) accession number: F5HG51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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