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Protein

VIRF-1

Gene

vIRF-1

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of host innate response by repressing the expression of interferon-inducible genes and blocking host IRF1- and IRF3-mediated transcription. Blocks the interaction between host IRF3 and CREBBP.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi89 – 195IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST107

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
VIRF-1
Gene namesi
Name:vIRF-1
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • host cell cytoplasm Source: ParkinsonsUK-UCL
  • host cell nucleus Source: ParkinsonsUK-UCL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004237781 – 449VIRF-1Add BLAST449

Interactioni

Subunit structurei

Interacts with host IRF3, IRF7, and CREBBP.1 Publication

GO - Molecular functioni

  • protein domain specific binding Source: CAFA

Protein-protein interaction databases

BioGridi1776967. 8 interactors.
IntActiF5HF68. 2 interactors.

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi92 – 102Combined sources11
Beta strandi109 – 112Combined sources4
Beta strandi117 – 121Combined sources5
Helixi132 – 135Combined sources4
Helixi137 – 145Combined sources9
Helixi153 – 155Combined sources3
Beta strandi156 – 158Combined sources3
Helixi159 – 169Combined sources11
Beta strandi174 – 181Combined sources8
Beta strandi187 – 193Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HLYX-ray1.48A/B88-196[»]
4YSIX-ray1.02B44-51[»]
ProteinModelPortaliF5HF68.
SMRiF5HF68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

KOiK10155.

Family and domain databases

CDDicd00103. IRF. 1 hit.
Gene3Di1.10.10.10. 1 hit.
2.60.200.10. 1 hit.
InterProiView protein in InterPro
IPR001346. Interferon_reg_fact_DNA-bd_dom.
IPR019471. Interferon_reg_factor-3.
IPR017855. SMAD_dom-like.
IPR008984. SMAD_FHA_domain.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11949. PTHR11949. 1 hit.
PfamiView protein in Pfam
PF00605. IRF. 1 hit.
PF10401. IRF-3. 1 hit.
SMARTiView protein in SMART
SM00348. IRF. 1 hit.
SM01243. IRF-3. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF49879. SSF49879. 1 hit.
PROSITEiView protein in PROSITE
PS51507. IRF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HF68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGQRPNPF GAPGAIPKKP CLSQGSPGTS GSGAPCDEPS RSESPGEGPS
60 70 80 90 100
GTGGSAAAGD ITRQAVVAAI TEWSRTRQLR ISTGASEGKA SIKDWIVCQV
110 120 130 140 150
NSGKFPGVEW EDEERTRFRI PVTPLADPCF EWRRDGELGV VYIRERGNMP
160 170 180 190 200
VDASFKGTRG RRRMLAALRR TRGLQEIGKG ISQDGHHFLV FRVRKPEEEQ
210 220 230 240 250
CVECGVVAGA VHDFNNMARL LQEGFFSPGQ CLPGEIVTPV PSCTTAEGQE
260 270 280 290 300
AVIDWGRLFI RMYYNGEQVH ELLTTSQSGC RISSALRRDP AVHYCAVGSP
310 320 330 340 350
GQVWLPNVPN LACEIAKREL CDTLDACAKG ILLTSSCNGI FCVCYHNGPV
360 370 380 390 400
HFIGNTVPPD SGPLLLPQGK PTRIFNPNTF LVGLANSPLP APSHVTCPLV
410 420 430 440
KLWLGKPVAV GKLEPHAPSP RDFAARCSNF SDACVVLEIM PKPLWDAMQ
Length:449
Mass (Da):48,460
Last modified:June 28, 2011 - v1
Checksum:i3C6A4E48FD57521A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28909.1.
RefSeqiYP_001129411.1. NC_009333.1.

Genome annotation databases

GeneIDi4961464.
KEGGivg:4961464.

Similar proteinsi

Entry informationi

Entry nameiVIRF1_HHV8P
AccessioniPrimary (citable) accession number: F5HF68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: August 30, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families