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Protein

Viral FLICE protein

Gene

ORF71

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the modulation of host signaling pathways by acting as an activator of both the classic and the alternative NF-kappa-B pathways. Thereby, initiates an important range of cellular processes to promote cell survival, proliferation and protection from apoptosis.2 Publications

GO - Biological processi

Keywordsi

Biological processActivation of host NF-kappa-B by virus, Apoptosis, Host-virus interaction, Inhibition of host apoptosis by viral FLIP-like protein, Modulation of host cell apoptosis by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Viral FLICE protein
Short name:
vFLIP
Gene namesi
Name:ORF71
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004239091 – 188Viral FLICE proteinAdd BLAST188

Interactioni

Subunit structurei

Interacts with host RIPK1, TRAF2, MAP3K14, IKBKB, and IKBKG.2 Publications

Protein-protein interaction databases

BioGridi1776997. 8 interactors.

Structurei

3D structure databases

ProteinModelPortaliF5HEZ4.
SMRiF5HEZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 74DED 1PROSITE-ProRule annotationAdd BLAST73
Domaini93 – 169DED 2PROSITE-ProRule annotationAdd BLAST77

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK04724.

Family and domain databases

InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR001875. DED_dom.
PfamiView protein in Pfam
PF01335. DED. 1 hit.
SMARTiView protein in SMART
SM00031. DED. 2 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50168. DED. 2 hits.

Sequencei

Sequence statusi: Complete.

F5HEZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYEVLCEV ARKLGTDDRE VVLFLLNVFI PQPTLAQLIG ALRALKEEGR
60 70 80 90 100
LTFPLLAECL FRAGRRDLLR DLLHLDPRFL ERHLAGTMSY FSPYQLTVLH
110 120 130 140 150
VDGELCARDI RSLIFLSKDT IGSRSTPQTF LHWVYCMENL DLLGPTDVDA
160 170 180
LMSMLRSLSR VDLQRQVQTL MGLHLSGPSH SQHYRHTP
Length:188
Mass (Da):21,474
Last modified:June 28, 2011 - v1
Checksum:i37CFE147EAE45371
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: AAD46498.1.
RefSeqiYP_001129429.1. NC_009333.1.

Genome annotation databases

GeneIDi4961494.
KEGGivg:4961494.

Similar proteinsi

Entry informationi

Entry nameiVFLIP_HHV8P
AccessioniPrimary (citable) accession number: F5HEZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: May 10, 2017
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome