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Protein

Membrane glycoprotein US3

Gene

US3

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Retains, but does not degrade MHC class I heterodimers in the endoplasmic reticulum during the immediate-early period of virus infection, thereby impairing their transport and maturation. Forms a complex with beta-2-microglobulin-associated class I heavy chains, which accumulate in the ER. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral immunoevasion
LigandLectin, Mannose-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane glycoprotein US3
Gene namesi
Name:US3
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 160LumenalSequence analysisAdd BLAST140
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 186CytoplasmicSequence analysis5

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000041672121 – 186Membrane glycoprotein US3Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 129By similarity
Glycosylationi60N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Post-translational modificationi

The signal sequence is not cleaved.By similarity
N-glycosylated; mostly exists in a high-mannose form.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiF5HEU0.

Expressioni

Developmental stagei

Expressed at immediate-early period of virus infection and at reduced levels at early-late times.

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1678085. 2 interactors.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytomegalovirus US2 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000Y5.

Family and domain databases

Gene3Di2.60.40.1200. 1 hit.
InterProiView protein in InterPro
IPR014749. Herpes_US2/U3_cytomegalovirus.
IPR009237. Herpes_US2/US3.
IPR014756. Ig_E-set.
PfamiView protein in Pfam
PF05963. Cytomega_US3. 1 hit.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F5HEU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPVLVLAIL AVLFLRLADS VPRPLNVVVS EIKSAHFRVE ENQCWFHMGM
60 70 80 90 100
LYFKGRMSGN FTKKHFVNVG IVSQSYMDRL QVSGEQYHHD ERGAYFEWNI
110 120 130 140 150
GGYPVSHTVD MVDITLSTRW GDPKKYAACV PQVRMDYSSQ TINWYLQRSM
160 170 180
RDDNWGLLFR TLLVYLFSLV VLVLLTVGVS ARLRFI
Length:186
Mass (Da):21,556
Last modified:June 28, 2011 - v1
Checksum:i34D58C17BE5EA06B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31694.1.
RefSeqiYP_081590.1. NC_006273.2.

Genome annotation databases

GeneIDi3077532.
KEGGivg:3077532.

Similar proteinsi

Entry informationi

Entry nameiUS03_HCMVM
AccessioniPrimary (citable) accession number: F5HEU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: June 28, 2011
Last modified: May 10, 2017
This is version 21 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families