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Protein

Protein UL78

Gene

UL78

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a cellular chemokine receptor and may modulate the host cell migration pattern which is the primary cellular event initiated by chemokine receptor activation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL78
Gene namesi
Name:UL78
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004183181 – 431Protein UL78Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi109 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Oligomerizes. Interacts with host CCR5 and CXCR4.1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi378 – 381Poly-Thr4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG0900009N.

Family and domain databases

InterProiView protein in InterPro
IPR017452. GPCR_Rhodpsn_7TM.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HET1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPSVEETTS VTESIMFAIV SFKHMGPFEG YSMSADRAAS DLLIGMFGSV
60 70 80 90 100
SLVNLLTIIG CLWVLRVTRP PVSVMIFTWN LVLSQFFSIL ATMLSKGIML
110 120 130 140 150
RGALNLSLCR LVLFVDDVGL YSTALFFLFL ILDRLSAISY GRDLWHHETR
160 170 180 190 200
ENAGVALYAV AFAWVLSIVA AVPTAATGSL DYRWLGCQIP IQYAAVDLTI
210 220 230 240 250
KMWFLLGAPM IAVLANVVEL AYSDRRDHVW SYVGRVCTFY VTCLMLFVPY
260 270 280 290 300
YCFRVLRGVL QPASAAGTGF GIMDYVELAT RTLLTMRLGI LPLFIIAFFS
310 320 330 340 350
REPTKDLDDS FDYLVERCQQ SCHGHFVRRL VQALKRAMYS VELAVCYFST
360 370 380 390 400
SVRDVAEAVK KSSSRCYADA TSAAVVVTTT TSEKATLVEH AEGMASEMCP
410 420 430
GTTIDVSAES SSVLCTDGEN TVASDATVTA L
Length:431
Mass (Da):47,357
Last modified:June 28, 2011 - v1
Checksum:i34668FE7F908C657
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31630.1.
RefSeqiYP_081526.1. NC_006273.2.

Genome annotation databases

GeneIDi3077549.
KEGGivg:3077549.

Similar proteinsi

Entry informationi

Entry nameiUL78_HCMVM
AccessioniPrimary (citable) accession number: F5HET1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: April 12, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families