Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Unique short US2 glycoprotein

Gene

US2

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Early protein that redirects newly synthesized MHC class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction. In consequence, infected cells are masked for immune recognition by cytotoxic T lymphocytes. Seems so far to be specific for HLA-A, HLA-B, and HFE loci products. Does not interact with HLA-DR or HLA-DM (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Unique short US2 glycoprotein
Alternative name(s):
Protein HQLF2
gpUS2
Gene namesi
Name:US2
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 161LumenalSequence analysisAdd BLAST161
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 199CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182921 – 199Unique short US2 glycoproteinAdd BLAST199
Signal peptidei1 – ?Not cleaved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 133By similarity
Glycosylationi68N-linked (GlcNAc...) asparagine; by hostBy similarity1

Post-translational modificationi

The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed at early period of virus infection.

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Monomer (Probable). Interacts with host TRAM1; this interaction promotes efficient US2-dependent dislocation of major histocompatibility complex class I heavy chains (By similarity).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1678095. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliF5HE05.
SMRiF5HE05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 137Ig-like H-typeAdd BLAST95

Domaini

The lumenal domain allows tight interaction with class I molecules encoded by the HLA-A locus.

Sequence similaritiesi

Belongs to the cytomegalovirus US2 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK21050.
OrthoDBiVOG090000PG.

Family and domain databases

Gene3Di2.60.40.1200. 1 hit.
InterProiView protein in InterPro
IPR014749. Herpes_US2/U3_cytomegalovirus.
IPR009237. Herpes_US2/US3.
IPR014756. Ig_E-set.
PfamiView protein in Pfam
PF05963. Cytomega_US3. 1 hit.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HE05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLWKAWVG LWTSMGPLIR LPDGITKAGE DALRPWKSTA KHPWFEIEDN
60 70 80 90 100
RCYIDNGKLF ARGSIVGNMS RFVFDPKADY GGVGENLYVH ADDVEFVPGE
110 120 130 140 150
SLKWNVRNLD VMPIFETLAL RLVLQGDVIW LRCVPELRVD YTSSAYMWNM
160 170 180 190
QYGMVRKSYT HVAWTIVFYS INITLLVLFI VYVTVDCNLS MMWMRFFVC
Length:199
Mass (Da):23,112
Last modified:June 28, 2011 - v1
Checksum:i201A43BDE87793E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31693.1.
RefSeqiYP_081589.1. NC_006273.2.

Genome annotation databases

GeneIDi3077542.
KEGGivg:3077542.

Similar proteinsi

Entry informationi

Entry nameiUS02_HCMVM
AccessioniPrimary (citable) accession number: F5HE05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: May 10, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families