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Protein

Protein ORF45

Gene

ORF45

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prevents the establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of host interferon regulatory factor 7/IRF7, a transcription factor critical for the induction of interferons alpha and beta. Mechanistically, ORF45 competes with the associated IRF7 and inhibits its phosphorylation by IKBKE or TBK1 by acting as an alternative substrate.2 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF7 by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ORF45
Gene namesi
Name:ORF45
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

F5HDE4:
  • Virion tegument 1 Publication
  • Host cytoplasm 1 Publication
  • Host nucleus 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004237701 – 407Protein ORF45Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Phosphoserine; by host TBK1 and IKKE1 Publication1
Modified residuei162Phosphoserine; by host TBK1 and IKKE1 Publication1

Post-translational modificationi

Phosphorylated on Ser-41 and Ser-162 by host IKBKE and TBK1.1 Publication

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiF5HDE4.

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with host IRF7.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IRF7Q929853EBI-8843990,EBI-968267From Homo sapiens.

Protein-protein interaction databases

IntActiF5HDE4. 1 interactor.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi284 – 294Nuclear export signalAdd BLAST11
Motifi297 – 300Nuclear localization signal4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 38Poly-Pro4

Phylogenomic databases

KOiK21859.

Sequencei

Sequence statusi: Complete.

F5HDE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMFVRTSSS THDEERMLPI EGAPRRRPPV KFIFPPPPLS SLPGFGRPRG
60 70 80 90 100
YAGPTVIDMS APDDVFAEDT PSPPATPLDL QISPDQSSGE SEYDEDEEDE
110 120 130 140 150
DEEENDDVQE EDEPEGYPAD FFQPLSHLRP RPLARRAHTP KPVAVVAGRV
160 170 180 190 200
RSSTDTAESE ASMGWVSQDD GFSPAGLSPS DDEGVAILEP MAAYTGTGAY
210 220 230 240 250
GLSPASRNSV PGTQSSPYSD PDEGPSWRPL RAAPTAIVDL TSDSDSDDSS
260 270 280 290 300
NSPDVNNEAA FTDARHFSHQ PPSSEEDGED QGEVLSQRIG LMDVGQKRKR
310 320 330 340 350
QSTASSGSED VVRCQRQPNL SRKAVASVII ISSGSDTDEE PSSAVSVIVS
360 370 380 390 400
PSSTKGHLPT QSPSTSAHSI SSGSTTTAGS RCSDPTRILA STPPLCGNGA

YNWPWLD
Length:407
Mass (Da):43,327
Last modified:June 28, 2011 - v1
Checksum:iF8F5876EFDA2BB35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28895.1.
RefSeqiYP_001129397.1. NC_009333.1.

Genome annotation databases

GeneIDi4961474.
KEGGivg:4961474.

Similar proteinsi

Entry informationi

Entry nameiORF45_HHV8P
AccessioniPrimary (citable) accession number: F5HDE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome