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Protein

Protein K7

Gene

K7

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of host apoptosis to allow completion of the viral lytic replication and may thus favor the maintenance of persistent infection in infected host.2 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Modulation of host cell apoptosis by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Protein K7
Gene namesi
Name:K7
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

F5HDA4:

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Host mitochondrion, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004238441 – 126Protein K7Add BLAST126

Interactioni

Subunit structurei

Interacts with host CAMLG; this interaction allows efficient apoptosis inhibition. Additionally, interacts with vGPCR/ORF74 and induces its proteasomeal degradation.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ORF74Q981465EBI-9002986,EBI-7930093

Protein-protein interaction databases

IntActiF5HDA4. 1 interactor.

Structurei

3D structure databases

SMRiF5HDA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK21661.

Sequencei

Sequence statusi: Complete.

F5HDA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTLEIKGAS LSQFSTGTAQ SPWLPLHLWI LCSLLAFLPL LVFIGAADCG
60 70 80 90 100
LIASLLAIYP SWLSARFSVL LFPHWPESCS TKNTARSGAL HKPAEQKLRF
110 120
AQKPCHGNYT VTPCGLLHWI QSPGQL
Length:126
Mass (Da):13,743
Last modified:June 28, 2011 - v1
Checksum:i189A7D9FCEDD91E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28865.1.
RefSeqiYP_001129367.1. NC_009333.1.

Genome annotation databases

GeneIDi4961500.
KEGGivg:4961500.

Similar proteinsi

Entry informationi

Entry nameiK7_HHV8P
AccessioniPrimary (citable) accession number: F5HDA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome