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Protein

Putative transcription activator ORF50

Gene

ORF50

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcription activation.Curated

GO - Molecular functioni

GO - Biological processi

  • bidirectional double-stranded viral DNA replication Source: UniProtKB
  • DNA-templated viral transcription Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription activator ORF50
Gene namesi
Name:ORF50
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004238011 – 691Putative transcription activator ORF50Add BLAST691

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Protein-protein interaction databases

BioGridi1777029. 8 interactors.

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TAF50 family.Curated

Family and domain databases

InterProiIPR004998. Herpes_TAF50.
[Graphical view]
PfamiPF03326. Herpes_TAF50. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5HCV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQDDKGKKL RRSCVESFVG LSDELKAQLY QCVLLINDAY ETIYDPSDLN
60 70 80 90 100
RVVEDVCIRI MKECSKLGAL CGLFTDINMF NLFCFFRASR MRTKGAAGYN
110 120 130 140 150
VPCAEASQGI IRILTERILF CTEKAFLTAA CSGVSLPPAI CKLLHEIYTE
160 170 180 190 200
MKAKCLGAWR RLVCNRRPIM ILTSSLLKLY NTYDTAGLLS EQSRALCLLV
210 220 230 240 250
FQPVYLPRIM APLEIMTKGQ LAPENFYSIT GSAEKRRPIT TGKVTGLSYP
260 270 280 290 300
GSGLMPESLI LPILEPGLLP ASMVDLSDVL AKPAVILSAP ALSQFVISKP
310 320 330 340 350
HPNMPHTVSI IPFNPSGTDP AFISTWQAAS QNMVYNTSTA PLKPATGSSQ
360 370 380 390 400
TVSVKAVAQG AVITATTVPQ AMPARGTGGE LPVMSASTPA RDQVAACFVA
410 420 430 440 450
ENTGDSPDNP SSFLTSCHPC DPNTVIVAQQ FQPPQCVTLL QVTCAPSSTP
460 470 480 490 500
PPDSTVRAPV VQLPTVVPLP ASAFLPALAQ PEASGEELPG GHDGDQGVPC
510 520 530 540 550
RDSTAAATAA EATTPKRKQR SKERSSKKRK ALTVPEADTT PSTTTPGTSL
560 570 580 590 600
GSITTPQDVH ATDVATSEGP SEAQPPLLSL PPPLDVDQSL FALLDEAGPE
610 620 630 640 650
TWDVGSPLSP TDDALLSSIL QGLYQLDTPP PLRSPSPASF GPESPADIPS
660 670 680 690
PSGGEYTQLQ PVRATSATPA NEVQESGTLY QLHQWRNYFR D
Length:691
Mass (Da):73,679
Last modified:June 28, 2011 - v1
Checksum:iEB6BE1F6B936EA60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28900.1.
RefSeqiYP_001129401.1. NC_009333.1.

Genome annotation databases

GeneIDi4961526.
KEGGivg:4961526.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28900.1.
RefSeqiYP_001129401.1. NC_009333.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1777029. 8 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4961526.
KEGGivg:4961526.

Family and domain databases

InterProiIPR004998. Herpes_TAF50.
[Graphical view]
PfamiPF03326. Herpes_TAF50. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiORF50_HHV8P
AccessioniPrimary (citable) accession number: F5HCV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: November 11, 2015
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.