Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

55 kDa immediate-early protein 1

Gene

UL123

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in transactivating viral early genes as well as activating its own promoter. Targets and disrupts host PML/nuclear domain 10 (ND10). Promotes efficient viral growth by interacting with and directing host SP100 to degradation, leading to enhanced acetylation level of histones. In addition, functions in counteracting the host innate antiviral response. Inhibits the type I interferon pathway by directly interacting with and sequestrating host STAT2. Alters host cell cycle progression, probably through its interaction with host E2F1 or RB1 that overcomes the RB1-mediated repression of E2F-responsive promoters (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processG1/S host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Modulation of host cell cycle by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
55 kDa immediate-early protein 1
Gene namesi
Name:UL123
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

  • Host nucleus

  • Note: Colocalizes with host PML-associated nuclear bodies.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004164461 – 49155 kDa immediate-early protein 1Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki450Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylated. Sumoylation abolishes the interaction with host STAT2 and thus the IE1-mediated repression of interferon-stimulated genes (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with human p53/TP53; this interaction inhibits p53/TP53-dependent transactivation activity. Interacts with host STAT2. Interacts with host DAXX, PML, and SP100. Interacts with host E2F1 and RB1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi1678066. 4 interactors.

Structurei

3D structure databases

SMRiF5HCM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni475 – 491Chromosome-tethering domain (CTD)By similarityAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi463 – 466Poly-Glu4

Domaini

The C-terminal 16-amino acid is termed the chromosome-tethering domain (CTD) and is required for proper IE1 activity and for association with host IE1, PML and STAT2.By similarity

Sequence similaritiesi

Belongs to the HHV-5 IE1 protein family.Curated

Phylogenomic databases

OrthoDBiVOG0900005Z.

Family and domain databases

InterProiView protein in InterPro
IPR010855. Cytomega_IE1.
PfamiView protein in Pfam
PF07340. Herpes_IE1. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HCM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSAKRKMD PDNPDEGPSS KVPRPETPVT KATTFLQTML RKEVNSQLSL
60 70 80 90 100
GDPLFPELAE ESLKTFEQVT EDCNENPEKD VLTELVKQIK VRVDMVRHRI
110 120 130 140 150
KEHMLKKYTQ TEEKFTGAFN MMGGCLQNAL DILDKVHEPF EDMKCIGLTM
160 170 180 190 200
QSMYENYIVP EDKREMWMAC IKELHDVSKG AANKLGGALQ AKARAKKDEL
210 220 230 240 250
RRKMMYMCYR NIEFFTKNSA FPKTTNGCSQ AMAALQNLPQ CSPDEIMSYA
260 270 280 290 300
QKIFKILDEE RDKVLTHIDH IFMDILTTCV ETMCNEYKVT SDACMMTMYG
310 320 330 340 350
GISLLSEFCR VLCCYVLEET SVMLAKRPLI TKPEVISVMK RRIEEICMKV
360 370 380 390 400
FAQYILGADP LRVCSPSVDD LRAIAEESDE EEAIVAYTLA TAGASSSDSL
410 420 430 440 450
VSPPESPVPA TIPLSSVIVA ENSDQEESEQ SDEEQEEGAQ EEREDTVSVK
460 470 480 490
SEPVSEIEEV ASEEEEDGAE EPTASGGKST HPMVTRSKAD Q
Length:491
Mass (Da):55,103
Last modified:June 28, 2011 - v1
Checksum:iE5BE99891AC4A4C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31666.1.
RefSeqiYP_081562.1. NC_006273.2.

Genome annotation databases

GeneIDi3077513.
KEGGivg:3077513.

Similar proteinsi

Entry informationi

Entry nameiVIE1_HCMVM
AccessioniPrimary (citable) accession number: F5HCM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 28, 2011
Last modified: July 5, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families