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Protein

DNA polymerase processivity factor

Gene

UL44

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Accessory subunit of the DNA polymerase that acts to increase the processivity of polymerization.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase processivity factor
Alternative name(s):
Polymerase accessory protein
Short name:
PAP
Protein ICP36
Gene namesi
Name:UL44
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182581 – 433DNA polymerase processivity factorAdd BLAST433

Interactioni

Subunit structurei

Forms homodimers. Interacts with host SMARCB1. Interacts with host NCL/nucleolin; this interaction is important for the organization of proteins within viral replication compartments. Interacts with UL112/UL113; this interaction is necessary for efficient viral DNA replication. Interacts with UL84. Interacts with the uracil DNA glycosylase UL114. Interacts with the DNA polymerase catalytic subunit UL54 (By similarity).By similarity

Protein-protein interaction databases

BioGridi1678013. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliF5HC97.
SMRiF5HC97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi291 – 297Poly-Gly7
Compositional biasi325 – 337Poly-GlyAdd BLAST13
Compositional biasi343 – 349Poly-Gly7
Compositional biasi356 – 360Poly-Gly5
Compositional biasi385 – 397Poly-GlyAdd BLAST13

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000FA.

Family and domain databases

InterProiView protein in InterPro
IPR004997. Herpes_PAP.
PfamiView protein in Pfam
PF03325. Herpes_PAP. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HC97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRKTRLSEP PTLALRLKPY KTAIQQLRSV IRALKENTTV TFLPTPSLIL
60 70 80 90 100
QTVRSHCVSK ITFNSSCLYI TDKSFQPKTI NNSTPLLGNF MYLTSSKDLT
110 120 130 140 150
KFYVQDISDL SAKISMCAPD FNMEFSSACV HGQDIVRESE NSAVHVDLDF
160 170 180 190 200
GVVADLLKWI GPHTRVKRNV KKAPCPTGTV QILVHAGPPA IKFILTNGSE
210 220 230 240 250
LEFTANNRVS FHGVKNMRIN VQLKNFYQTL LNCAVTKLPC TLRIVTEHDT
260 270 280 290 300
LLYVASRNGL FAVENFLTEE PFQRGDPFDK NYVGNSGKSR GGGGGSGSLS
310 320 330 340 350
SLANAGGLHD DGPGLDNDIM NEPMGLGGLG GGGGGGGKKH DRGGGGGSGT
360 370 380 390 400
RKMSSGGGGG DHDHGLSSKE KYEQHKITSY LTSKGGSGGG GGGGGGGLDR
410 420 430
NSGNYFNDAK EESDSEDSVT FEFVPNTKKQ KCG
Length:433
Mass (Da):46,263
Last modified:June 28, 2011 - v1
Checksum:iDC7669CA7121B2C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31608.1.
RefSeqiYP_081502.1. NC_006273.2.

Genome annotation databases

GeneIDi3077460.
KEGGivg:3077460.

Similar proteinsi

Entry informationi

Entry nameiVPAP_HCMVM
AccessioniPrimary (citable) accession number: F5HC97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: February 15, 2017
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families