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Protein

Viral interleukin-10 homolog

Gene

UL111A

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Functional viral IL-10 homolog. Can bind to the human IL-10 receptor and compete with human IL-10 for binding sites. Requires both subunits of the human IL-10 receptor complex to induce signal transduction events and biological activities. IL-10 signaling pathway has several immunosuppressive activities that are exploited by the virus. Inhibits TLR-induced type I interferon production in host plasmacytoid dendritic cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processEvasion of host immunity by viral interleukin-like protein, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Modulation of host dendritic cell activity by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Viral interleukin-10 homolog
Short name:
cmvIL-10
Short name:
vIL-10
Gene namesi
Name:UL111A
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000041643826 – 176Viral interleukin-10 homologAdd BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 128By similarity
Disulfide bondi79InterchainBy similarity
Disulfide bondi82 ↔ 133By similarity
Glycosylationi152N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliF5HC71.
SMRiF5HC71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 30Poly-Thr4

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiVOG090000WI.

Family and domain databases

Gene3Di4.10.340.10. 1 hit.
InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR012352. IL-10_add_hlx.
IPR020423. IL-10_CS.
PfamiView protein in Pfam
PF00726. IL10. 1 hit.
SMARTiView protein in SMART
SM00188. IL10. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00520. INTERLEUKIN_10. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F5HC71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSVMVSSSL VLIVFFLGAS EEAKPATTTT IKNTKPQCRP EDYATRLQDL
60 70 80 90 100
RVTFHRVKPT LQREDDYSVW LDGTVVKGCW GCSVMDWLLR RYLEIVFPAG
110 120 130 140 150
DHVYPGLKTE LHSMRSTLES IYKDMRQCPL LGCGDKSVIS RLSQEAERKS
160 170
DNGTRKGLSE LDTLFSRLEE YLHSRK
Length:176
Mass (Da):20,108
Last modified:June 28, 2011 - v1
Checksum:iDAC25EBFDFA9A872
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31656.1.
RefSeqiYP_081552.1. NC_006273.2.

Genome annotation databases

GeneIDi3077506.
KEGGivg:3077506.

Similar proteinsi

Entry informationi

Entry nameiIL10H_HCMVM
AccessioniPrimary (citable) accession number: F5HC71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families