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Protein

Chemokine vCXCL1

Gene

UL146

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a functional chemokine, inducing calcium mobilization, chemotaxis, and degranulation of neutrophils. Contributes to the induction of neutrophil chemotaxis by interacting with host CXCR1 and CXCR2 receptors.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host chemokines by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine vCXCL1
Gene namesi
Name:UL146
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182591 – 120Chemokine vCXCL1Add BLAST120

Interactioni

Subunit structurei

Interacts with host CXCR1 and CXCR2.1 Publication

GO - Molecular functioni

Structurei

3D structure databases

SMRiF5HBX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK21046.
OrthoDBiVOG090001KP.

Family and domain databases

InterProiView protein in InterPro
IPR036048. Interleukin_8-like_sf.
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HBX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLIFGALII SLTYMYYYEV HGTELRCKCL DGKKLPPKTI MLGNFWFHRE
60 70 80 90 100
SGGPRCNNNE YFLYLGGGKK HGPGVCLSPH HPFSKWLDKR NDNRWYNVNV
110 120
TRQPERGPGK ITVTLVGLKE
Length:120
Mass (Da):13,872
Last modified:June 28, 2011 - v1
Checksum:iD5247AF226EA2093
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31675.1.
RefSeqiYP_081571.1. NC_006273.2.

Genome annotation databases

GeneIDi3077566.
KEGGivg:3077566.

Similar proteinsi

Entry informationi

Entry nameiCXCL1_HCMVM
AccessioniPrimary (citable) accession number: F5HBX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families