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Protein

Portal protein

Gene

UL104

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocates the viral DNA, termed terminase.UniRule annotation

GO - Biological processi

Keywordsi

Biological processViral genome packaging, Virus exit from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Portal proteinUniRule annotation
Gene namesi
Name:UL104
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182681 – 697Portal proteinAdd BLAST697

Interactioni

Subunit structurei

Homododecamerizes. Interacts with terminase subunits TRM1 and TRM3.UniRule annotation

Structurei

3D structure databases

SMRiF5HBR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi415 – 420Poly-Pro6

Sequence similaritiesi

Belongs to the herpesviridae portal protein family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

OrthoDBiVOG0900002I.

Family and domain databases

HAMAPiMF_04012. HSV_PORTL. 1 hit.
InterProiView protein in InterPro
IPR002660. Herpes_Portal.
PfamiView protein in Pfam
PF01763. Herpes_UL6. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HBR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNHWNEKS SGAKRSRERD LTLSTIRSIL AADERLRIKA SSYLGVGRGV
60 70 80 90 100
DDEAVIDIFP TGQTMSFLRL LHGFLGTCRG QSMHQVLRDP CVLRKQLLYG
110 120 130 140 150
VCKTLFDTIT VRRVAEEWKL HAALFPYRAL DEEDLEQYLL VWSASLRQSV
160 170 180 190 200
QTGVLGALRD ILYQYADNDD YGLYVDWCVT VGLVPLLDVK TKPSEAAERA
210 220 230 240 250
QFVRAAVQRA TETHPLAQDL LQANLALLLQ VAERLGAVRI ANAPEVRVFK
260 270 280 290 300
KVRSERLEAQ LRGKHIRLYV AAEPLAYERD KLLFTTPVAH LHEEILRYDG
310 320 330 340 350
LCRHQKICQL LNTFPVKVVT ASRHELNCKK LVEMMEQHDR GSDAKKSIMK
360 370 380 390 400
FLLNVSDSKS RIGIEDSVES FLQDLTPSLV DQNRLLPARG PGGPGVVGPG
410 420 430 440 450
GAVVGGPAGH VGLLPPPPGP AAPERDIRDL FKKQVIKCLE EQIQSQVDEI
460 470 480 490 500
QDLRTLNQTW ENRVRELRDL LTRYASRRED SMSLGARDAE LYHLPVLEAV
510 520 530 540 550
RKARDAAPFR PLAVEDNRLV ANSFFSQFVP GTESLERFLT QLWENEYFRT
560 570 580 590 600
FRLRRLVTHQ GAEEAIVYSN YTVERVTLPY LCHILALGTL DPVPEAYLQL
610 620 630 640 650
SFGEIVAAAY DDSKFCRYVE LICSREKARR RQMSREAAGG VPERGTASSG
660 670 680 690
GPGTLERSAP RRLITADEER RGPERVGRFR NGGPDDPRRA GGPYGFH
Length:697
Mass (Da):78,535
Last modified:June 28, 2011 - v1
Checksum:iD166B32C875E321A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31654.1.
RefSeqiYP_081550.1. NC_006273.2.

Genome annotation databases

GeneIDi3077547.
KEGGivg:3077547.

Similar proteinsi

Entry informationi

Entry nameiPORTL_HCMVM
AccessioniPrimary (citable) accession number: F5HBR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: March 15, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families