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F5HB62

- KITH_HHV8P

UniProt

F5HB62 - KITH_HHV8P

Protein

Thymidine kinase

Gene

ORF21

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei287 – 2871Proton acceptorBy similarity
    Binding sitei300 – 3001SubstrateBy similarity
    Binding sitei325 – 3251SubstrateBy similarity
    Binding sitei415 – 4151ATPBy similarity
    Binding sitei421 – 4211SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi260 – 2678ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:ORF21
    OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
    Taxonomic identifieri868565 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000000942: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 580580Thymidine kinasePRO_0000423759Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliF5HB62.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR013672. Herpes_TK_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    PF08465. Herpes_TK_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F5HB62-1 [UniParc]FASTAAdd to Basket

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    MAEGGFGADS VGRGGEKASV TRGGRWDLGS SDDESSTSTT STDMDDLPEE    50
    RKPLTGKSVK TSYIYDVPTV PTSKPWHLMH DNSLYATPRF PPRPLIRHPS 100
    EKGSIFASRL SATDDDSGDY APMDRFAFQS PRVCGRPPLP PPNHPPPATR 150
    PADASMGDVG WADLQGLKRT PKGFLKTSTK GGSLKARGRD VGDRLRDGGF 200
    AFSPRGVKSA IGQNIKSWLG IGESSATAVP VTTQLMVPVH LIRTPVTVDY 250
    RNVYLLYLEG VMGVGKSTLV NAVCGILPQE RVTSFPEPMV YWTRAFTDCY 300
    KEISHLMKSG KAGDPLTSAK IYSCQNKFSL PFRTNATAIL RMMQPWNVGG 350
    GSGRGTHWCV FDRHLLSPAV VFPLMHLKHG RLSFDHFFQL LSIFRATEGD 400
    VVAILTLSSA ESLRRVRARG RKNDGTVEQN YIRELAWAYH AVYCSWIMLQ 450
    YITVEQMVQL CVQTTNIPEI CFRSVRLAHK EETLKNLHEQ SMLPMITGVL 500
    DPVRHHPVVI ELCFCFFTEL RKLQFIVADA DKFHDDVCGL WTEIYRQILS 550
    NPAIKPRAIN WPALESQSKA VNHLEETCRV 580
    Length:580
    Mass (Da):64,537
    Last modified:June 28, 2011 - v1
    Checksum:iC34E41D6B181DAFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF148805 Genomic DNA. Translation: ABD28872.1.
    RefSeqiYP_001129374.1. NC_009333.1.

    Genome annotation databases

    GeneIDi4961484.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF148805 Genomic DNA. Translation: ABD28872.1 .
    RefSeqi YP_001129374.1. NC_009333.1.

    3D structure databases

    ProteinModelPortali F5HB62.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4961484.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR013672. Herpes_TK_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    PF08465. Herpes_TK_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus."
      Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.
      J. Virol. 73:6953-6963(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview."
      Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.
      J. Gen. Virol. 87:1781-1804(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_HHV8P
    AccessioniPrimary (citable) accession number: F5HB62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 16, 2013
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3