Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

F5HB62

- KITH_HHV8P

UniProt

F5HB62 - KITH_HHV8P

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Thymidine kinase

Gene

ORF21

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as cells that do not replicate their genome.By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei287 – 2871Proton acceptorBy similarity
Binding sitei300 – 3001SubstrateBy similarity
Binding sitei325 – 3251SubstrateBy similarity
Binding sitei415 – 4151ATPBy similarity
Binding sitei421 – 4211SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi260 – 2678ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:ORF21
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000942: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Thymidine kinasePRO_0000423759Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliF5HB62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HB62-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEGGFGADS VGRGGEKASV TRGGRWDLGS SDDESSTSTT STDMDDLPEE
60 70 80 90 100
RKPLTGKSVK TSYIYDVPTV PTSKPWHLMH DNSLYATPRF PPRPLIRHPS
110 120 130 140 150
EKGSIFASRL SATDDDSGDY APMDRFAFQS PRVCGRPPLP PPNHPPPATR
160 170 180 190 200
PADASMGDVG WADLQGLKRT PKGFLKTSTK GGSLKARGRD VGDRLRDGGF
210 220 230 240 250
AFSPRGVKSA IGQNIKSWLG IGESSATAVP VTTQLMVPVH LIRTPVTVDY
260 270 280 290 300
RNVYLLYLEG VMGVGKSTLV NAVCGILPQE RVTSFPEPMV YWTRAFTDCY
310 320 330 340 350
KEISHLMKSG KAGDPLTSAK IYSCQNKFSL PFRTNATAIL RMMQPWNVGG
360 370 380 390 400
GSGRGTHWCV FDRHLLSPAV VFPLMHLKHG RLSFDHFFQL LSIFRATEGD
410 420 430 440 450
VVAILTLSSA ESLRRVRARG RKNDGTVEQN YIRELAWAYH AVYCSWIMLQ
460 470 480 490 500
YITVEQMVQL CVQTTNIPEI CFRSVRLAHK EETLKNLHEQ SMLPMITGVL
510 520 530 540 550
DPVRHHPVVI ELCFCFFTEL RKLQFIVADA DKFHDDVCGL WTEIYRQILS
560 570 580
NPAIKPRAIN WPALESQSKA VNHLEETCRV
Length:580
Mass (Da):64,537
Last modified:June 28, 2011 - v1
Checksum:iC34E41D6B181DAFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28872.1.
RefSeqiYP_001129374.1. NC_009333.1.

Genome annotation databases

GeneIDi4961484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28872.1 .
RefSeqi YP_001129374.1. NC_009333.1.

3D structure databases

ProteinModelPortali F5HB62.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4961484.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus."
    Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.
    J. Virol. 73:6953-6963(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview."
    Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.
    J. Gen. Virol. 87:1781-1804(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_HHV8P
AccessioniPrimary (citable) accession number: F5HB62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: October 1, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3