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F5HB62

- KITH_HHV8P

UniProt

F5HB62 - KITH_HHV8P

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Protein
Thymidine kinase
Gene
ORF21
Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as cells that do not replicate their genome By similarity.

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei287 – 2871Proton acceptor By similarity
Binding sitei300 – 3001Substrate By similarity
Binding sitei325 – 3251Substrate By similarity
Binding sitei415 – 4151ATP By similarity
Binding sitei421 – 4211Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi260 – 2678ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:ORF21
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000000942: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580Thymidine kinase
PRO_0000423759Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliF5HB62.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HB62-1 [UniParc]FASTAAdd to Basket

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MAEGGFGADS VGRGGEKASV TRGGRWDLGS SDDESSTSTT STDMDDLPEE    50
RKPLTGKSVK TSYIYDVPTV PTSKPWHLMH DNSLYATPRF PPRPLIRHPS 100
EKGSIFASRL SATDDDSGDY APMDRFAFQS PRVCGRPPLP PPNHPPPATR 150
PADASMGDVG WADLQGLKRT PKGFLKTSTK GGSLKARGRD VGDRLRDGGF 200
AFSPRGVKSA IGQNIKSWLG IGESSATAVP VTTQLMVPVH LIRTPVTVDY 250
RNVYLLYLEG VMGVGKSTLV NAVCGILPQE RVTSFPEPMV YWTRAFTDCY 300
KEISHLMKSG KAGDPLTSAK IYSCQNKFSL PFRTNATAIL RMMQPWNVGG 350
GSGRGTHWCV FDRHLLSPAV VFPLMHLKHG RLSFDHFFQL LSIFRATEGD 400
VVAILTLSSA ESLRRVRARG RKNDGTVEQN YIRELAWAYH AVYCSWIMLQ 450
YITVEQMVQL CVQTTNIPEI CFRSVRLAHK EETLKNLHEQ SMLPMITGVL 500
DPVRHHPVVI ELCFCFFTEL RKLQFIVADA DKFHDDVCGL WTEIYRQILS 550
NPAIKPRAIN WPALESQSKA VNHLEETCRV 580
Length:580
Mass (Da):64,537
Last modified:June 28, 2011 - v1
Checksum:iC34E41D6B181DAFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF148805 Genomic DNA. Translation: ABD28872.1.
RefSeqiYP_001129374.1. NC_009333.1.

Genome annotation databases

GeneIDi4961484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF148805 Genomic DNA. Translation: ABD28872.1 .
RefSeqi YP_001129374.1. NC_009333.1.

3D structure databases

ProteinModelPortali F5HB62.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4961484.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of a spliced gene from Kaposi's sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus."
    Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.
    J. Virol. 73:6953-6963(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview."
    Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.
    J. Gen. Virol. 87:1781-1804(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_HHV8P
AccessioniPrimary (citable) accession number: F5HB62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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