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Protein

Viral inhibitor of caspase-8-induced apoptosis

Gene

UL36

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of apoptosis by interacting with the pro-domain of pro-caspase-8/CASP8 and thus preventing its activation.1 Publication

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host caspases by virus, Modulation of host cell apoptosis by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Viral inhibitor of caspase-8-induced apoptosis
Short name:
vICA
Gene namesi
Name:UL36
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131C → R: Complete loss of interaction with Pro-caspase 8. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182991 – 476Viral inhibitor of caspase-8-induced apoptosisAdd BLAST476

Interactioni

Subunit structurei

Interacts with host pro-caspase-8/CASP8; this interaction inhibits CASP8 activation.1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi327 – 332Poly-Asp6
Compositional biasi442 – 445Poly-Arg4

Sequence similaritiesi

Belongs to the herpesviridae US22 family.Curated

Phylogenomic databases

OrthoDBiVOG0900006W.

Family and domain databases

InterProiView protein in InterPro
IPR003360. US22-like.
PfamiView protein in Pfam
PF02393. US22. 2 hits.

Sequencei

Sequence statusi: Complete.

F5HAY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLRDTLMA YGCIAIRAGD FNGLNDFLEQ ECGTRLHVAW PERCFIQLRS
60 70 80 90 100
RSALGPFVGK MGTVCSQGAY VCCQEYLHPF GFVEGPGFMR YQLIVLIGQR
110 120 130 140 150
GGIYCYDDLR DCIYELAPTM KDFLRHGFRH CDHFHTMRDY QRPMVQYDDY
160 170 180 190 200
WNAVMLYRGD VESLSAEVTK RGYASYSIDD PFDECPDTHF AFWTHNTEVM
210 220 230 240 250
KFKETSFSVV RAGGSIQTME LMIRTVPRIT CYHQLLGALG HEVPERKEFL
260 270 280 290 300
VRQYVLVDTF GVVYGYDPAM DAVYRLAEDV VMFTCVMGKK GHRNHRFSGR
310 320 330 340 350
REAIVRLEKT PTCQHPKKTP DPMIMFDEDD DDELSLPRNV MTHEEAESRL
360 370 380 390 400
YDAITENLMH CVKLVTTDSP LATHLWPQEL QALCDSPALS LCTDDVEGVR
410 420 430 440 450
QKLRARTGSL HHFELSYRFH DEDPETYMGF LWDIPSCDRC VRRRRFKVCD
460 470
VGRRHIIPGA ANGMPPLTPP HAYMNN
Length:476
Mass (Da):54,924
Last modified:June 28, 2011 - v1
Checksum:iBEF2E05AA58785FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31601.1.
RefSeqiYP_081495.1. NC_006273.2.

Genome annotation databases

GeneIDi3077442.
KEGGivg:3077442.

Similar proteinsi

Entry informationi

Entry nameiVICA_HCMVM
AccessioniPrimary (citable) accession number: F5HAY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: March 15, 2017
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families