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Protein

Envelope glycoprotein H

Gene

gH

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity). Targets host EPHA2 to promote KSHV entry.UniRule annotation2 Publications

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell
LigandSialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein HUniRule annotation
Short name:
gHUniRule annotation
Gene namesi
Name:gHUniRule annotation
Synonyms:ORF22
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

  • Virion membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
  • Host cell membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
  • Host endosome membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

  • Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 706Virion surfaceUniRule annotationAdd BLAST685
Transmembranei707 – 727HelicalUniRule annotationAdd BLAST21
Topological domaini728 – 730IntravirionUniRule annotation3

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host endosome, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_000043665522 – 730Envelope glycoprotein HUniRule annotationAdd BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi54N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi101N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi125N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi131N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi188N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi209N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi215N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi267N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi274N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi365N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi556N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi613N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi626N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi688N-linked (GlcNAc...) asparagine; by hostUniRule annotation1

Post-translational modificationi

N-glycosylated, O-glycosylated, and sialylated.UniRule annotation

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion (By similarity). When in complex with gL, interacts with host EPHA2; this interaction triggers EPHA2 phosphorylation and endocytosis allowing KSHV entry.UniRule annotation1 Publication

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni190 – 254Interaction with gLUniRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein H family.UniRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG0900004Y.

Family and domain databases

HAMAPiMF_04033. HSV_GH. 1 hit.
InterProiView protein in InterPro
IPR003493. Herpes_gH.
IPR035305. Herpes_glycoH_C.
PfamiView protein in Pfam
PF17488. Herpes_glycoH_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F5HAK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGLAFLAAL ACWRCISLTC GATGALPTTA TTITRSATQL INGRTNLSIE
60 70 80 90 100
LEFNGTSFFL NWQNLLNVIT EPALTELWTS AEVAEDLRVT LKKRQSLFFP
110 120 130 140 150
NKTVVISGDG HRYTCEVPTS SQTYNITKGF NYSALPGHLG GFGINARLVL
160 170 180 190 200
GDIFASKWSL FARDTPEYRV FYPMNVMAVK FSISIGNNES GVALYGVVSE
210 220 230 240 250
DFVVVTLHNR SKEANETASH LLFGLPDSLP SLKGHATYDE LTFARNAKYA
260 270 280 290 300
LVAILPKDSY QTLLTENYTR IFLNMTESTP LEFTRTIQTR IVSIEARRAC
310 320 330 340 350
AAQEAAPDIF LVLFQMLVAH FLVARGIAEH RFVEVDCVCR QYAELYFLRR
360 370 380 390 400
ISRLCMPTFT TVGYNHTTLG AVAATQIARV SATKLASLPR SSQETVLAMV
410 420 430 440 450
QLGARDGAVP SSILEGIAMV VEHMYTAYTY VYTLGDTERK LMLDIHTVLT
460 470 480 490 500
DSCPPKDSGV SEKLLRTYLM FTSMCTNIEL GEMIARFSKP DSLNIYRAFS
510 520 530 540 550
PCFLGLRYDL HPAKLRAEAP QSSALTRTAV ARGTSGFAEL LHALHLDSLN
560 570 580 590 600
LIPAINCSKI TADKIIATVP LPHVTYIISS EALSNAVVYE VSEIFLKSAM
610 620 630 640 650
FISAIKPDCS GFNFSQIDRH IPIVYNISTP RRGCPLCDSV IMSYDESDGL
660 670 680 690 700
QSLMYVTNER VQTNLFLDKS PFFDNNNLHI HYLWLRDNGT VVEIRGMYRR
710 720 730
RAASALFLIL SFIGFSGVIY FLYRLFSILY
Length:730
Mass (Da):81,266
Last modified:June 28, 2011 - v1
Checksum:iB5DB4B733DDFE451
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28873.1.
RefSeqiYP_001129375.1. NC_009333.1.

Genome annotation databases

GeneIDi4961506.
KEGGivg:4961506.

Similar proteinsi

Entry informationi

Entry nameiGH_HHV8P
AccessioniPrimary (citable) accession number: F5HAK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: August 30, 2017
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families