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Protein

Triplex capsid protein 1

Gene

TRX1

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein 1UniRule annotation
Gene namesi
Name:TRX1UniRule annotation
Ordered Locus Names:UL46
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182561 – 290Triplex capsid protein 1Add BLAST290

Interactioni

Subunit structurei

Interacts with TRX2, MCP and capsid vertex component 2/CVC2.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRX1 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000J1.

Family and domain databases

HAMAPiMF_04018. HSV_TRX1. 1 hit.
InterProiView protein in InterPro
IPR004999. Herpes_1.
PfamiView protein in Pfam
PF03327. Herpes_VP19C. 1 hit.

Sequencei

Sequence statusi: Complete.

F5HA93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDARAVAKRP RDPADEDNEL VTALKAKREV NTISVRYLYH ADHQALTARF
60 70 80 90 100
FVPEGLVEFE AQPGALLIRM ETGCDSPRHL YISLYLLGIR ASNVSASTRC
110 120 130 140 150
LLESVYTASA ARAALQWLDL GPHLLHRRLE TLGCVKTVSL GITSLLTCVM
160 170 180 190 200
RGYLYNTLKT EVFALMIPKD MYLTWEETRG RLQYVYLIIV YDYDGPETRP
210 220 230 240 250
GIYVLTSSIA HWQTLVDVAR GKFARERCSF VNRRITRPRQ IPLCTGVIQK
260 270 280 290
LGWCLADDIH TSFLVHKELK LSVVRLDNFS VELGDFREFV
Length:290
Mass (Da):33,027
Last modified:June 28, 2011 - v1
Checksum:iADB19CE379503D17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA. Translation: AAR31610.1.
RefSeqiYP_081504.1. NC_006273.2.

Genome annotation databases

GeneIDi3077431.
KEGGivg:3077431.

Similar proteinsi

Entry informationi

Entry nameiTRX1_HCMVM
AccessioniPrimary (citable) accession number: F5HA93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: February 15, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families