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Protein

Triplex capsid protein 1

Gene

TRX1

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein 1UniRule annotation
Gene namesi
Name:TRX1UniRule annotation
Ordered Locus Names:ORF62
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004237691 – 331Triplex capsid protein 1Add BLAST331

Interactioni

Subunit structurei

Interacts with TRX2, MCP and capsid vertex component 2/CVC2.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRX1 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000FJ.

Family and domain databases

HAMAPiMF_04018. HSV_TRX1. 1 hit.
InterProiView protein in InterPro
IPR004999. Herpes_1.
PfamiView protein in Pfam
PF03327. Herpes_VP19C. 1 hit.

Sequencei

Sequence statusi: Complete.

F5H8Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVQAENAAR LGRQVLGLLP PPTHRVSLTR GPEFARGVRD LLSKYAASTR
60 70 80 90 100
PTVGSLHEAL RQAPFRQPTY GDFLVYSQTF SPQEPLGTFL FSFKQEDNGS
110 120 130 140 150
SMDMLLTPTS LFMLSGMEAA KAPQTHKVAG VWYGSGSGLA DFIPNLSELM
160 170 180 190 200
DTGEFHTLLT PVGPMVQSVH STFVTKVTSA MKGVGLARDE PRAHVGLTLP
210 220 230 240 250
CDMLVDLDES CPMVQRREPA GLNVTIYASL VYLRVNQRPS MALTFFQSGK
260 270 280 290 300
GFAEVVAMIK DHFTDVIRTK YIQLRHELYI NRLVFGAVCT LGTVPFDSHP
310 320 330
VHQSLNVKGT SLPVLVFANF EAACGPWTVF L
Length:331
Mass (Da):36,336
Last modified:June 28, 2011 - v1
Checksum:i91113380F7C0B7FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA. Translation: ABD28917.1.
RefSeqiYP_001129419.1. NC_009333.1.

Genome annotation databases

GeneIDi4961461.
KEGGivg:4961461.

Similar proteinsi

Entry informationi

Entry nameiTRX1_HHV8P
AccessioniPrimary (citable) accession number: F5H8Y5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: February 15, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families