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F5H8W5

- F5H8W5_CRYNB

UniProt

F5H8W5 - F5H8W5_CRYNB

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Protein
DNA ligase
Gene
CNBH3980
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:CNBH3980Imported
OrganismiCryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic identifieri283643 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesTremellaceaeFilobasidiellaFilobasidiella/Cryptococcus neoformans species complex
ProteomesiUP000001435: Chromosome 8

Structurei

3D structure databases

ProteinModelPortaliF5H8W5.
SMRiF5H8W5. Positions 164-787.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H8W5-1 [UniParc]FASTAAdd to Basket

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MSDIEYPVKS NIRKKRTVIL SDDEDEGLGP SVIKEQVSSP KHSHLSDEET    50
EPPRKVAKTS SKVAPIFAPK EKKEKPSPKT SSALSKAPAK KIEVKSKGEK 100
PLASIFTKAT RKPEPKDDDE MSDEVKQKGK DEEEEDEIYD EVEDKQEGEA 150
AVKLASIFTK NQKSVPVADK GWKDGEAVPY PALVSTFEKI EATTKRLEIL 200
EFLTQFLLVV AKRDTATDAK GSMLLKVVYL CINRLCPDYM GIELGIGESL 250
LIKAIAESTG RAMPKIKEDL KKEGDLGKVA MNSRNTQSTM FKPKPLTVPY 300
VFQCLTDIAK ASGNASQAKK VGIIKKLLAA CQGTEAKFII RSLEGKLRIG 350
LADKTVVVAL AHAIVLKTIG DKKPPPEKLA IMLEQGAETV KAVYSELPSY 400
DLVIPALLQG GVEGLRERCK LTPGVPLKPM LAKPTKAITE VLDRFEGKEF 450
TCEYKYDGER AQVHLLEDGT ISVFSRNSEN MSAKYPDLVD QIPRSMKPTA 500
KTFVIDAEAV AYDLETKKIL PFQDLSRRKR KDVKAEDITV RVHIFAFDLL 550
YLNGESLLAK ELKERRQLLQ EHFQPVESEF AFAKSSDGST TEEIQALLEE 600
SVKDGCEGLM VKMLTSESST YEPSRRSMNW LKLKKDYLSG VGDSLDLVVV 650
GAYHGKGKRT AVYGAFLLAC YDPDSEHYQT ICKIGTGFSE EILTQFYELL 700
KPLELEVVRG DIEVGGAKPD VWFEPRVVWE VLTADLSLSP IYAAAHGVID 750
SRGISLRFPR FIRIRDDKSA DEATTAEQVS EFYQRQISAG GKKGAGADVD 800
DFW 803
Length:803
Mass (Da):89,050
Last modified:June 28, 2011 - v1
Checksum:i8F400926CE1B836A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEY01000042 Genomic DNA. Translation: EAL19299.1.
RefSeqiXP_773946.1. XM_768853.1.

Genome annotation databases

GeneIDi4937926.
KEGGicnb:CNBH3980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAEY01000042 Genomic DNA. Translation: EAL19299.1 .
RefSeqi XP_773946.1. XM_768853.1.

3D structure databases

ProteinModelPortali F5H8W5.
SMRi F5H8W5. Positions 164-787.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4937926.
KEGGi cnb:CNBH3980.

Phylogenomic databases

KOi K10747.
OrthoDBi EOG7TXKRG.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans."
    Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D., Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E., Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A., Fox D.S.
    , Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.
    Science 307:1321-1324(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B-3501A.

Entry informationi

Entry nameiF5H8W5_CRYNB
AccessioniPrimary (citable) accession number: F5H8W5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 19, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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