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Protein
Submitted name:

Coagulation factor VII

Gene

F7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169Charge relay systemUniRule annotation1
Active sitei218Charge relay systemUniRule annotation1
Active sitei320Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Coagulation factor VIIImported
Gene namesi
Name:F7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000057593.13
HGNCiHGNC:3544 F7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000057593

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500332476921 – 382Sequence analysisAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 57PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiF5H8B0
PRIDEiF5H8B0

Expressioni

Gene expression databases

BgeeiENSG00000057593
ExpressionAtlasiF5H8B0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H8B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 58EGF-likeInterPro annotationAdd BLAST37
Domaini129 – 368Peptidase S1InterPro annotationAdd BLAST240

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIMB Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118890

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR033190 F7
IPR012224 Pept_S1A_FX
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PANTHERiPTHR44064:SF1 PTHR44064:SF1, 1 hit
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001143 Factor_X, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00179 EGF_CA, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
PS01187 EGF_CA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

F5H8B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSQALRLLC LLLGLQGCLA ADGDQCASSP CQNGGSCKDQ LQSYICFCLP
60 70 80 90 100
AFEGRNCETH KDDQLICVNE NGGCEQYCSD HTGTKRSCRC HEGYSLLADG
110 120 130 140 150
VSCTPTVEYP CGKIPILEKR NASKPQGRIV GGKVCPKGEC PWQVLLLVNG
160 170 180 190 200
AQLCGGTLIN TIWVVSAAHC FDKIKNWRNL IAVLGEHDLS EHDGDEQSRR
210 220 230 240 250
VAQVIIPSTY VPGTTNHDIA LLRLHQPVVL TDHVVPLCLP ERTFSERTLA
260 270 280 290 300
FVRFSLVSGW GQLLDRGATA LELMVLNVPR LMTQDCLQQS RKVGDSPNIT
310 320 330 340 350
EYMFCAGYSD GSKDSCKGDS GGPHATHYRG TWYLTGIVSW GQGCATVGHF
360 370 380
GVYTRVSQYI EWLQKLMRSE PRPGVLLRAP FP
Length:382
Mass (Da):41,879
Last modified:October 29, 2014 - v2
Checksum:i9D63822120051CDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137002 Genomic DNA No translation available.
RefSeqiNP_001254483.1, NM_001267554.1
UniGeneiHs.36989

Genome annotation databases

EnsembliENST00000541084; ENSP00000442051; ENSG00000057593
GeneIDi2155
UCSCiuc010tjt.4 human

Similar proteinsi

Entry informationi

Entry nameiF5H8B0_HUMAN
AccessioniPrimary (citable) accession number: F5H8B0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: May 23, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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