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Protein
Submitted name:

Coagulation factor VII

Gene

F7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169Charge relay systemUniRule annotation1
Active sitei218Charge relay systemUniRule annotation1
Active sitei320Charge relay systemUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Coagulation factor VIIImported
Gene namesi
Name:F7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:3544. F7.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000057593.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500332476921 – 382Sequence analysisAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 57PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiF5H8B0.
PeptideAtlasiF5H8B0.
PRIDEiF5H8B0.

Expressioni

Gene expression databases

BgeeiENSG00000057593.
ExpressionAtlasiF5H8B0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364731.

Structurei

3D structure databases

ProteinModelPortaliF5H8B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 58EGF-likeInterPro annotationAdd BLAST37
Domaini129 – 368Peptidase S1InterPro annotationAdd BLAST240

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIMB. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR033190. F7.
IPR012224. Pept_S1A_FX.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PANTHERiPTHR24256:SF375. PTHR24256:SF375. 1 hit.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF00089. Trypsin. 1 hit.
PIRSFiPIRSF001143. Factor_X. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

F5H8B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSQALRLLC LLLGLQGCLA ADGDQCASSP CQNGGSCKDQ LQSYICFCLP
60 70 80 90 100
AFEGRNCETH KDDQLICVNE NGGCEQYCSD HTGTKRSCRC HEGYSLLADG
110 120 130 140 150
VSCTPTVEYP CGKIPILEKR NASKPQGRIV GGKVCPKGEC PWQVLLLVNG
160 170 180 190 200
AQLCGGTLIN TIWVVSAAHC FDKIKNWRNL IAVLGEHDLS EHDGDEQSRR
210 220 230 240 250
VAQVIIPSTY VPGTTNHDIA LLRLHQPVVL TDHVVPLCLP ERTFSERTLA
260 270 280 290 300
FVRFSLVSGW GQLLDRGATA LELMVLNVPR LMTQDCLQQS RKVGDSPNIT
310 320 330 340 350
EYMFCAGYSD GSKDSCKGDS GGPHATHYRG TWYLTGIVSW GQGCATVGHF
360 370 380
GVYTRVSQYI EWLQKLMRSE PRPGVLLRAP FP
Length:382
Mass (Da):41,879
Last modified:October 29, 2014 - v2
Checksum:i9D63822120051CDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137002 Genomic DNA. No translation available.
RefSeqiNP_001254483.1. NM_001267554.1.
UniGeneiHs.36989.

Genome annotation databases

EnsembliENST00000541084; ENSP00000442051; ENSG00000057593.
GeneIDi2155.
UCSCiuc010tjt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137002 Genomic DNA. No translation available.
RefSeqiNP_001254483.1. NM_001267554.1.
UniGeneiHs.36989.

3D structure databases

ProteinModelPortaliF5H8B0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364731.

Proteomic databases

PaxDbiF5H8B0.
PeptideAtlasiF5H8B0.
PRIDEiF5H8B0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541084; ENSP00000442051; ENSG00000057593.
GeneIDi2155.
UCSCiuc010tjt.4. human.

Organism-specific databases

CTDi2155.
HGNCiHGNC:3544. F7.
OpenTargetsiENSG00000057593.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIMB. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.

Miscellaneous databases

GenomeRNAii2155.

Gene expression databases

BgeeiENSG00000057593.
ExpressionAtlasiF5H8B0. baseline and differential.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiView protein in InterPro
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR033190. F7.
IPR012224. Pept_S1A_FX.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PANTHERiPTHR24256:SF375. PTHR24256:SF375. 1 hit.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF00089. Trypsin. 1 hit.
PIRSFiPIRSF001143. Factor_X. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF5H8B0_HUMAN
AccessioniPrimary (citable) accession number: F5H8B0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: February 15, 2017
This is version 48 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.