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Protein
Submitted name:

Coagulation factor VII

Gene

F7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691Charge relay systemUniRule annotation
Active sitei218 – 2181Charge relay systemUniRule annotation
Active sitei320 – 3201Charge relay systemUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Coagulation factor VIIImported
Gene namesi
Name:F7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:3544. F7.

Subcellular locationi

  • Secreted SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 382362Sequence analysisPRO_5003324769Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF5H8B0.

Expressioni

Gene expression databases

BgeeiF5H8B0.
ExpressionAtlasiF5H8B0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000364731.

Structurei

3D structure databases

ProteinModelPortaliF5H8B0.
SMRiF5H8B0. Positions 23-118, 129-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 5837EGF-likeInterPro annotationAdd
BLAST
Domaini129 – 368240Peptidase S1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation
Contains 1 peptidase S1 domain.UniRule annotation

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IIMB. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR033190. F7.
IPR012224. Pept_S1A_FX.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PANTHERiPTHR24256:SF212. PTHR24256:SF212. 1 hit.
PfamiPF00008. EGF. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001143. Factor_X. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H8B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSQALRLLC LLLGLQGCLA ADGDQCASSP CQNGGSCKDQ LQSYICFCLP
60 70 80 90 100
AFEGRNCETH KDDQLICVNE NGGCEQYCSD HTGTKRSCRC HEGYSLLADG
110 120 130 140 150
VSCTPTVEYP CGKIPILEKR NASKPQGRIV GGKVCPKGEC PWQVLLLVNG
160 170 180 190 200
AQLCGGTLIN TIWVVSAAHC FDKIKNWRNL IAVLGEHDLS EHDGDEQSRR
210 220 230 240 250
VAQVIIPSTY VPGTTNHDIA LLRLHQPVVL TDHVVPLCLP ERTFSERTLA
260 270 280 290 300
FVRFSLVSGW GQLLDRGATA LELMVLNVPR LMTQDCLQQS RKVGDSPNIT
310 320 330 340 350
EYMFCAGYSD GSKDSCKGDS GGPHATHYRG TWYLTGIVSW GQGCATVGHF
360 370 380
GVYTRVSQYI EWLQKLMRSE PRPGVLLRAP FP
Length:382
Mass (Da):41,879
Last modified:October 29, 2014 - v2
Checksum:i9D63822120051CDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137002 Genomic DNA. No translation available.
RefSeqiNP_001254483.1. NM_001267554.1.
UniGeneiHs.36989.

Genome annotation databases

EnsembliENST00000541084; ENSP00000442051; ENSG00000057593.
GeneIDi2155.
UCSCiuc010tjt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137002 Genomic DNA. No translation available.
RefSeqiNP_001254483.1. NM_001267554.1.
UniGeneiHs.36989.

3D structure databases

ProteinModelPortaliF5H8B0.
SMRiF5H8B0. Positions 23-118, 129-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364731.

Proteomic databases

PaxDbiF5H8B0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541084; ENSP00000442051; ENSG00000057593.
GeneIDi2155.
UCSCiuc010tjt.4. human.

Organism-specific databases

CTDi2155.
HGNCiHGNC:3544. F7.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIMB. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118890.

Miscellaneous databases

GenomeRNAii2155.

Gene expression databases

BgeeiF5H8B0.
ExpressionAtlasiF5H8B0. baseline and differential.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR033190. F7.
IPR012224. Pept_S1A_FX.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PANTHERiPTHR24256:SF212. PTHR24256:SF212. 1 hit.
PfamiPF00008. EGF. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001143. Factor_X. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00181. EGF. 2 hits.
SM00179. EGF_CA. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS01187. EGF_CA. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H8B0_HUMAN
AccessioniPrimary (citable) accession number: F5H8B0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: June 8, 2016
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.