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Protein
Submitted name:

Tumor necrosis factor receptor superfamily member 1A

Gene

TNFRSF1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily member 1AImported
Gene namesi
Name:TNFRSF1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:11916. TNFRSF1A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei212 – 234HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000067182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500332309130 – 298Sequence analysisAdd BLAST269

Proteomic databases

MaxQBiF5H8A6.
PaxDbiF5H8A6.
PeptideAtlasiF5H8A6.
PRIDEiF5H8A6.

Expressioni

Gene expression databases

BgeeiENSG00000067182.
ExpressionAtlasiF5H8A6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000162749.

Structurei

3D structure databases

ProteinModelPortaliF5H8A6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 81TNFR-CysInterPro annotationAdd BLAST39
Domaini83 – 125TNFR-CysInterPro annotationAdd BLAST43
Domaini126 – 166TNFR-CysInterPro annotationAdd BLAST41

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
GeneTreeiENSGT00530000064001.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F5H8A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSTVPDLL LPLVLLELLV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI
60 70 80 90 100
HPQNNSICCT KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL
110 120 130 140 150
SCSKCRKEMG QVEISSCTVD RDTVCGCRKN QYRHYWSENL FQCFNCSLCL
160 170 180 190 200
NGTVHLSCQE KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQIE
210 220 230 240 250
NVKGTEDSGT TVLLPLVIFF GLCLLSLLFI GLMYRYQRWK SKLYSIGEWG
260 270 280 290
LWEGEGAGGG EGGHGWVRWT CVEGGEECPL SSYRWGLWAE GGPGWLGR
Length:298
Mass (Da):33,167
Last modified:June 28, 2011 - v1
Checksum:iD62A4E2E91A44DC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei298Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006057 Genomic DNA. No translation available.
KF455591 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000539372; ENSP00000442059; ENSG00000067182.
UCSCiuc058kda.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006057 Genomic DNA. No translation available.
KF455591 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliF5H8A6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000162749.

Proteomic databases

MaxQBiF5H8A6.
PaxDbiF5H8A6.
PeptideAtlasiF5H8A6.
PRIDEiF5H8A6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000539372; ENSP00000442059; ENSG00000067182.
UCSCiuc058kda.1. human.

Organism-specific databases

HGNCiHGNC:11916. TNFRSF1A.
OpenTargetsiENSG00000067182.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
GeneTreeiENSGT00530000064001.

Miscellaneous databases

ChiTaRSiTNFRSF1A. human.

Gene expression databases

BgeeiENSG00000067182.
ExpressionAtlasiF5H8A6. baseline and differential.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF5H8A6_HUMAN
AccessioniPrimary (citable) accession number: F5H8A6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.