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F5H801

- F5H801_HUMAN

UniProt

F5H801 - F5H801_HUMAN

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Protein
Submitted name: 2-oxoglutarate dehydrogenase, mitochondrial
Gene
OGDH
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase, mitochondrialImported
Gene namesi
Name:OGDHImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:8124. OGDH.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF5H801.

Expressioni

Gene expression databases

ArrayExpressiF5H801.
BgeeiF5H801.

Structurei

3D structure databases

ProteinModelPortaliF5H801.
SMRiF5H801. Positions 70-965.

Family & Domainsi

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

F5H801-1 [UniParc]FASTAAdd to Basket

« Hide

MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS RGSLAAVAHA    50
QSLVEAQPNV DKLVEDHLAV QSLIRAYQVR GHHIAKLDPL GISCVNFDDA 100
PVTVSSNVDL AVFKERLRML TVGGFYGLDE SDLDKVFHLP TTTFIGGQES 150
ALPLREIIRR LEMAYCQHIG VEFMFINDLE QCQWIRQKFE TPGIMQFTNE 200
EKRTLLARLV RSTRFEEFLQ RKWSSEKRFG LEGCEVLIPA LKTIIDKSSE 250
NGVDYVIMGM PHRGRLNVLA NVIRKELEQI FCQFDSKLEA ADEGSGDVKY 300
HLGMYHRRIN RVTDRNITLS LVANPSHLEA ADPVVMGKTK AEQFYCGDTE 350
GKKVMSILLH GDAAFAGQGI VYETFHLSDL PSYTTHGTVH VVVNNQIGFT 400
TDPRMARSSP YPTDVARVVN APIFHVNSDD PEAVMYVCKV AAEWRSTFHK 450
DVVVDLVCYR RNGHNEMDEP MFTQPLMYKQ IRKQKPVLQK YAELLVSQGV 500
VNQPEYEEEI SKYDKICEEA FARSKDEKIL HIKHWLDSPW PGFFTLDGQP 550
RSMSCPSTGL TEDILTHIGN VASSVPVENF TIHGGLSRIL KTRGEMVKNR 600
TVDWALAEYM AFGSLLKEGI HIRLSGQDVE RGTFSHRHHV LHDQNVDKRT 650
CIPMNHLWPN QAPYTVCNSS LSEYGVLGFE LGFAMASPNA LVLWEAQFGD 700
FHNTAQCIID QFICPGQAKW VRQNGIVLLL PHGMEGMGPE HSSARPERFL 750
QMCNDDPDVL PDLKEANFDI NQLYDCNWVV VNCSTPGNFF HVLRRQILLP 800
FRKPLIIFTP KSLLRHPEAR SSFDEMLPGT HFQRVIPEDG PAAQNPENVK 850
RLLFCTGKVY YDLTRERKAR DMVGQVAITR IEQLSPFPFD LLLKEVQKYP 900
NAELAWCQEE HKNQGYYDYV KPRLRTTISR AKPVWYAGRD PAAAPATGNK 950
KTHLTELQRL LDTAFDLDVF KNFS 974
Length:974
Mass (Da):110,611
Last modified:June 28, 2011 - v1
Checksum:iA6D759D0FD096C7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004859 Genomic DNA. No translation available.
AC011894 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000543843; ENSP00000443821; ENSG00000105953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC004859 Genomic DNA. No translation available.
AC011894 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F5H801.
SMRi F5H801. Positions 70-965.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F5H801.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000543843 ; ENSP00000443821 ; ENSG00000105953 .

Organism-specific databases

HGNCi HGNC:8124. OGDH.
GenAtlasi Search...

Miscellaneous databases

ChiTaRSi OGDH. human.
NextBioi 35509480.

Gene expression databases

ArrayExpressi F5H801.
Bgeei F5H801.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H801_HUMAN
AccessioniPrimary (citable) accession number: F5H801
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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