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Protein
Submitted name:

Tropomyosin alpha-1 chain

Gene

TPM1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Tropomyosin alpha-1 chainImported
Gene namesi
Name:TPM1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:12010. TPM1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140416.

PTM / Processingi

Proteomic databases

EPDiF5H7S3.
MaxQBiF5H7S3.
PeptideAtlasiF5H7S3.
PRIDEiF5H7S3.

Expressioni

Gene expression databases

BgeeiENSG00000140416.
ExpressionAtlasiF5H7S3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H7S3.
SMRiF5H7S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili7 – 245Sequence analysisAdd BLAST239

Sequence similaritiesi

Belongs to the tropomyosin family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074494.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H7S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGSSSLEAV RRKIRSLQEQ ADAAEERAGT LQRELDHERK LRETAEADVA
60 70 80 90 100
SLNRRIQLVE EELDRAQERL ATALQKLEEA EKAADESERG MKVIESRAQK
110 120 130 140 150
DEEKMEIQEI QLKEAKHIAE DADRKYEEVA RKLVIIESDL ERAEERAELS
160 170 180 190 200
EGQVRQLEEQ LRIMDQTLKA LMAAEDKYSQ KEDRYEEEIK VLSDKLKEAE
210 220 230 240
TRAEFAERSV TKLEKSIDDL EDQLYQQLEQ NRRLTNELKL ALNED
Length:245
Mass (Da):28,525
Last modified:February 22, 2012 - v2
Checksum:i599EF5A43C1BF72F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079328 Genomic DNA. No translation available.
RefSeqiNP_001317280.1. NM_001330351.1.
UniGeneiHs.133892.
Hs.602995.

Genome annotation databases

EnsembliENST00000317516; ENSP00000322577; ENSG00000140416.
GeneIDi7168.
UCSCiuc002alr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079328 Genomic DNA. No translation available.
RefSeqiNP_001317280.1. NM_001330351.1.
UniGeneiHs.133892.
Hs.602995.

3D structure databases

ProteinModelPortaliF5H7S3.
SMRiF5H7S3.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiF5H7S3.
MaxQBiF5H7S3.
PeptideAtlasiF5H7S3.
PRIDEiF5H7S3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317516; ENSP00000322577; ENSG00000140416.
GeneIDi7168.
UCSCiuc002alr.4. human.

Organism-specific databases

CTDi7168.
HGNCiHGNC:12010. TPM1.
OpenTargetsiENSG00000140416.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074494.

Miscellaneous databases

ChiTaRSiTPM1. human.
GenomeRNAii7168.

Gene expression databases

BgeeiENSG00000140416.
ExpressionAtlasiF5H7S3. baseline and differential.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF5H7S3_HUMAN
AccessioniPrimary (citable) accession number: F5H7S3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: February 22, 2012
Last modified: November 30, 2016
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.