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Protein

Protein Wnt

Gene

WNT5B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotationSAAS annotation

Keywords - Biological processi

Wnt signaling pathwayUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein WntUniRule annotation
Gene namesi
Name:WNT5BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16265. WNT5B.

Subcellular locationi

  • Secretedextracellular spaceextracellular matrix UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrixSAAS annotation, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_500841432518 – 253Protein WntSequence analysisAdd BLAST236

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiF5H7Q6.
PeptideAtlasiF5H7Q6.
PRIDEiF5H7Q6.

Expressioni

Gene expression databases

BgeeiENSG00000111186.
ExpressionAtlasiF5H7Q6. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308887.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F5H7Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLLLLFTA ALLSSWAQLL TDANSWWSLA LNPVQRPEMF IIGAQPVCSQ
60 70 80 90 100
LPGLSPGQRK LCQLYQEHMA YIGEGAKTGI KECQHQFRQR RWNCSTADNA
110 120 130 140 150
SVFGRVMQIG SRETAFTHAV SAAGVVNAIS RACREGELST CGCSRTARPK
160 170 180 190 200
DLPRDWLWGG CGDNVEYGYR FAKEFVDARE REKNFAKGSE EQGRVLMNLQ
210 220 230 240 250
NNEAGRRAVY KMADVACKCH GVSGSCSLKT CWLQLAEFRK VGDRLKEKYD

SAA
Length:253
Mass (Da):28,153
Last modified:October 5, 2016 - v8
Checksum:iC768C02C6E799683
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei253Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004671 Genomic DNA. No translation available.
AC005182 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000543071; ENSP00000442348; ENSG00000111186.
UCSCiuc058jsd.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004671 Genomic DNA. No translation available.
AC005182 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308887.

Proteomic databases

PaxDbiF5H7Q6.
PeptideAtlasiF5H7Q6.
PRIDEiF5H7Q6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000543071; ENSP00000442348; ENSG00000111186.
UCSCiuc058jsd.1. human.

Organism-specific databases

HGNCiHGNC:16265. WNT5B.
OpenTargetsiENSG00000111186.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3913. Eukaryota.
ENOG410XQZ1. LUCA.
GeneTreeiENSGT00760000118943.

Miscellaneous databases

ChiTaRSiWNT5B. human.

Gene expression databases

BgeeiENSG00000111186.
ExpressionAtlasiF5H7Q6. baseline and differential.

Family and domain databases

InterProiIPR005817. Wnt.
IPR026537. Wnt5b.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PTHR12027:SF87. PTHR12027:SF87. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF5H7Q6_HUMAN
AccessioniPrimary (citable) accession number: F5H7Q6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 5, 2016
Last modified: November 2, 2016
This is version 45 of the entry and version 8 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.