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Protein
Submitted name:

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Gene

PPWD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, RotamaseUniRule annotation

Enzyme and pathway databases

SignaLinkiF5H7P7.

Names & Taxonomyi

Protein namesi
Submitted name:
Peptidylprolyl isomerase domain and WD repeat-containing protein 1Imported
Gene namesi
Name:PPWD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:28954. PPWD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiF5H7P7.
PaxDbiF5H7P7.

Expressioni

Gene expression databases

BgeeiF5H7P7.
ExpressionAtlasiF5H7P7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261308.

Structurei

3D structure databases

ProteinModelPortaliF5H7P7.
SMRiF5H7P7. Positions 72-288, 327-362, 452-616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 14085WD_REPEATS_REGIONInterPro annotationAdd
BLAST
Domaini460 – 615156PPIase cyclophilin-typeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.UniRule annotation

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

eggNOGiKOG0882. Eukaryota.
ENOG410XQB4. LUCA.
GeneTreeiENSGT00760000119072.
KOiK12736.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H7P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRTKSAGLD LYLWRQHWPR RGKQPHEVGI SNSYLVLEFE RVYLDNLPSA
60 70 80 90 100
SMYERSYMHR DVITHVVCTK TDFIITASHD GHVKFWKKIE EGIEFVKHFR
110 120 130 140 150
SHLGVIESIA VSSEGALFCS VGDDKAMKVF DVVNFDMINM LKLGYFPGQC
160 170 180 190 200
EWIYCPGDAI SSVAASEKST GKIFIYDGRG DNQPLHIFDK LHTSPLTQIR
210 220 230 240 250
LNPVYKAVVS SDKSGMIEYW TGPPHEYKFP KNVNWEYKTD TDLYEFAKCK
260 270 280 290 300
AYPTSVCFSP DGKKIATIGS DRKVRIFRFV TGKLMRVFDE SLSMFTELQQ
310 320 330 340 350
MRQQLPDMEF GRRMAVEREL EKVDAVRLIN IVFDETGHFV LYGTMLGIKV
360 370 380 390 400
INVETNRCVR ILGKQENIRV MQLALFQGIA KKHRAATTIE MKASENPVLQ
410 420 430 440 450
NIQADPTIVC TSFKKNRFYM FTKREPEDTK SADSDRDVFN EKPSKEEVMA
460 470 480 490 500
ATQAEGPKRV SDSAIIHTSM GDIHTKLFPV ECPKTVENFC VHSRNGYYNG
510 520 530 540 550
HTFHRIIKGF MIQTGDPTGT GMGGESIWGG EFEDEFHSTL RHDRPYTLSM
560 570 580 590 600
ANAGSNTNGS QFFITVVPTP WLDNKHTVFG RVTKGMEVVQ RISNVKVNPK
610
TDKPYEDVSI INITVK
Length:616
Mass (Da):70,276
Last modified:June 28, 2011 - v1
Checksum:iC891FFFD684726AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008560 Genomic DNA. No translation available.
KC877011 Genomic DNA. No translation available.
RefSeqiNP_001265855.1. NM_001278926.1.
UniGeneiHs.121432.

Genome annotation databases

EnsembliENST00000535264; ENSP00000442371; ENSG00000113593.
GeneIDi23398.
KEGGihsa:23398.
UCSCiuc011cqv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008560 Genomic DNA. No translation available.
KC877011 Genomic DNA. No translation available.
RefSeqiNP_001265855.1. NM_001278926.1.
UniGeneiHs.121432.

3D structure databases

ProteinModelPortaliF5H7P7.
SMRiF5H7P7. Positions 72-288, 327-362, 452-616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000261308.

Proteomic databases

EPDiF5H7P7.
PaxDbiF5H7P7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000535264; ENSP00000442371; ENSG00000113593.
GeneIDi23398.
KEGGihsa:23398.
UCSCiuc011cqv.4. human.

Organism-specific databases

CTDi23398.
HGNCiHGNC:28954. PPWD1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0882. Eukaryota.
ENOG410XQB4. LUCA.
GeneTreeiENSGT00760000119072.
KOiK12736.

Enzyme and pathway databases

SignaLinkiF5H7P7.

Miscellaneous databases

ChiTaRSiPPWD1. human.
GenomeRNAii23398.
NextBioi35509425.

Gene expression databases

BgeeiF5H7P7.
ExpressionAtlasiF5H7P7. baseline and differential.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H7P7_HUMAN
AccessioniPrimary (citable) accession number: F5H7P7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 11, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.