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Protein
Submitted name:

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Gene

PPWD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotation

Enzyme and pathway databases

SignaLinkiF5H7P7

Names & Taxonomyi

Protein namesi
Submitted name:
Peptidylprolyl isomerase domain and WD repeat-containing protein 1Imported
Gene namesi
Name:PPWD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113593.11
HGNCiHGNC:28954 PPWD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113593

PTM / Processingi

Proteomic databases

MaxQBiF5H7P7
PeptideAtlasiF5H7P7
PRIDEiF5H7P7

Expressioni

Gene expression databases

BgeeiENSG00000113593
ExpressionAtlasiF5H7P7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H7P7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 140WD_REPEATS_REGIONInterPro annotationAdd BLAST85
Repeati99 – 140WDPROSITE-ProRule annotationAdd BLAST42
Domaini460 – 615PPIase cyclophilin-typeInterPro annotationAdd BLAST156

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0882 Eukaryota
ENOG410XQB4 LUCA
GeneTreeiENSGT00760000119072

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR00153 CSAPPISMRASE
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50891 SSF50891, 1 hit
SSF50978 SSF50978, 3 hits
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

F5H7P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRTKSAGLD LYLWRQHWPR RGKQPHEVGI SNSYLVLEFE RVYLDNLPSA
60 70 80 90 100
SMYERSYMHR DVITHVVCTK TDFIITASHD GHVKFWKKIE EGIEFVKHFR
110 120 130 140 150
SHLGVIESIA VSSEGALFCS VGDDKAMKVF DVVNFDMINM LKLGYFPGQC
160 170 180 190 200
EWIYCPGDAI SSVAASEKST GKIFIYDGRG DNQPLHIFDK LHTSPLTQIR
210 220 230 240 250
LNPVYKAVVS SDKSGMIEYW TGPPHEYKFP KNVNWEYKTD TDLYEFAKCK
260 270 280 290 300
AYPTSVCFSP DGKKIATIGS DRKVRIFRFV TGKLMRVFDE SLSMFTELQQ
310 320 330 340 350
MRQQLPDMEF GRRMAVEREL EKVDAVRLIN IVFDETGHFV LYGTMLGIKV
360 370 380 390 400
INVETNRCVR ILGKQENIRV MQLALFQGIA KKHRAATTIE MKASENPVLQ
410 420 430 440 450
NIQADPTIVC TSFKKNRFYM FTKREPEDTK SADSDRDVFN EKPSKEEVMA
460 470 480 490 500
ATQAEGPKRV SDSAIIHTSM GDIHTKLFPV ECPKTVENFC VHSRNGYYNG
510 520 530 540 550
HTFHRIIKGF MIQTGDPTGT GMGGESIWGG EFEDEFHSTL RHDRPYTLSM
560 570 580 590 600
ANAGSNTNGS QFFITVVPTP WLDNKHTVFG RVTKGMEVVQ RISNVKVNPK
610
TDKPYEDVSI INITVK
Length:616
Mass (Da):70,276
Last modified:June 28, 2011 - v1
Checksum:iC891FFFD684726AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008560 Genomic DNA No translation available.
KC877011 Genomic DNA No translation available.
RefSeqiNP_001265855.1, NM_001278926.1
UniGeneiHs.121432

Genome annotation databases

EnsembliENST00000535264; ENSP00000442371; ENSG00000113593
GeneIDi23398
UCSCiuc011cqv.4 human

Similar proteinsi

Entry informationi

Entry nameiF5H7P7_HUMAN
AccessioniPrimary (citable) accession number: F5H7P7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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