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Protein
Submitted name:

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Gene

PPWD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotation

Enzyme and pathway databases

SignaLinkiF5H7P7.

Names & Taxonomyi

Protein namesi
Submitted name:
Peptidylprolyl isomerase domain and WD repeat-containing protein 1Imported
Gene namesi
Name:PPWD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113593.11.
HGNCiHGNC:28954. PPWD1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000113593.

PTM / Processingi

Proteomic databases

MaxQBiF5H7P7.
PaxDbiF5H7P7.
PeptideAtlasiF5H7P7.
PRIDEiF5H7P7.

Expressioni

Gene expression databases

BgeeiENSG00000113593.
ExpressionAtlasiF5H7P7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H7P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 140WD_REPEATS_REGIONInterPro annotationAdd BLAST85
Repeati99 – 140WDPROSITE-ProRule annotationAdd BLAST42
Domaini460 – 615PPIase cyclophilin-typeInterPro annotationAdd BLAST156

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0882. Eukaryota.
ENOG410XQB4. LUCA.
GeneTreeiENSGT00760000119072.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom_sf.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PF00400. WD40. 2 hits.
PRINTSiPR00153. CSAPPISMRASE.
SMARTiView protein in SMART
SM00320. WD40. 4 hits.
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEiView protein in PROSITE
PS50072. CSA_PPIASE_2. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

F5H7P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRTKSAGLD LYLWRQHWPR RGKQPHEVGI SNSYLVLEFE RVYLDNLPSA
60 70 80 90 100
SMYERSYMHR DVITHVVCTK TDFIITASHD GHVKFWKKIE EGIEFVKHFR
110 120 130 140 150
SHLGVIESIA VSSEGALFCS VGDDKAMKVF DVVNFDMINM LKLGYFPGQC
160 170 180 190 200
EWIYCPGDAI SSVAASEKST GKIFIYDGRG DNQPLHIFDK LHTSPLTQIR
210 220 230 240 250
LNPVYKAVVS SDKSGMIEYW TGPPHEYKFP KNVNWEYKTD TDLYEFAKCK
260 270 280 290 300
AYPTSVCFSP DGKKIATIGS DRKVRIFRFV TGKLMRVFDE SLSMFTELQQ
310 320 330 340 350
MRQQLPDMEF GRRMAVEREL EKVDAVRLIN IVFDETGHFV LYGTMLGIKV
360 370 380 390 400
INVETNRCVR ILGKQENIRV MQLALFQGIA KKHRAATTIE MKASENPVLQ
410 420 430 440 450
NIQADPTIVC TSFKKNRFYM FTKREPEDTK SADSDRDVFN EKPSKEEVMA
460 470 480 490 500
ATQAEGPKRV SDSAIIHTSM GDIHTKLFPV ECPKTVENFC VHSRNGYYNG
510 520 530 540 550
HTFHRIIKGF MIQTGDPTGT GMGGESIWGG EFEDEFHSTL RHDRPYTLSM
560 570 580 590 600
ANAGSNTNGS QFFITVVPTP WLDNKHTVFG RVTKGMEVVQ RISNVKVNPK
610
TDKPYEDVSI INITVK
Length:616
Mass (Da):70,276
Last modified:June 28, 2011 - v1
Checksum:iC891FFFD684726AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008560 Genomic DNA. No translation available.
KC877011 Genomic DNA. No translation available.
RefSeqiNP_001265855.1. NM_001278926.1.
UniGeneiHs.121432.

Genome annotation databases

EnsembliENST00000535264; ENSP00000442371; ENSG00000113593.
GeneIDi23398.
UCSCiuc011cqv.4. human.

Similar proteinsi

Entry informationi

Entry nameiF5H7P7_HUMAN
AccessioniPrimary (citable) accession number: F5H7P7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 22, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported