SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

F5H7P6

- F5H7P6_HUMAN

UniProt

F5H7P6 - F5H7P6_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Non-lysosomal glucosylceramidase
Gene
GBA2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide By similarity.UniRule annotation

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

GO - Molecular functioni

  1. glucosylceramidase activity Source: UniProtKB-EC

GO - Biological processi

  1. glucosylceramide catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Lipid metabolismUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Non-lysosomal glucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
Short name:
NLGaseUniRule annotation
Gene namesi
Name:GBA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:18986. GBA2.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Golgi apparatusUniRule annotation, MembraneUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiF5H7P6.

Expressioni

Gene expression databases

ArrayExpressiF5H7P6.
BgeeiF5H7P6.

Structurei

3D structure databases

ProteinModelPortaliF5H7P6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK17108.
OMAiYQLPGQN.
PhylomeDBiF5H7P6.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR014551. Beta_glucosidase_GBA2-type.
IPR024462. GBA2_N.
IPR006775. Glucosylceramidase.
[Graphical view]
PfamiPF04685. DUF608. 1 hit.
PF12215. GBA2_N. 1 hit.
[Graphical view]
PIRSFiPIRSF028944. Beta_gluc_GBA2. 1 hit.
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequencei

Sequence statusi: Complete.

F5H7P6-1 [UniParc]FASTAAdd to Basket

« Hide

MGTQDPGNMG TGVPASEQIS CAKEDPQVYC PEETGGTKDV QVTDCKSPED    50
SRPPKETDCC NPEDSGQLMV SYEGKAMGYQ VPPFGWRICL AHEFTEKRKP 100
FQANNVSLSN MIKHIGMGLR YLQWWYRKTH VEKKTPFIDM INSVPLRQIY 150
GCPLGGIGGG TITRGWRGQF CRWQLNPGMY QHRTVIADQP ICPLKFTVCL 200
RREGQTVYQQ VLSLERPSVL RSWNWGLCGY FAFYHALYPR AWTVYQLPGQ 250
NVTLTCRQIT PILPHDYQDS SLPVGVFVWD VENEGDEALD VSIMFSMRNG 300
LGGGDDAPGG LWNEPFCLER SGETVRGLLL HHPTLPNPYT MAVAARVTAA 350
TTVTHITAFD PDSTGQQVWQ DLLQDGQLDS PTGQSTPTQK GVGIAGAVCV 400
SSKLRPRGQC RLEFSLAWDM PRIMFGAKGQ VHYRRYTRFF GQDGDAAPAL 450
SHYALCRYAE WEERISAWQS PVLDDRSLPA WYKSALFNEL YFLADGGTVW 500
LEVLEDSLPE ELGRNMCHLR PTLRDYGRFG YLEGQEYRMY NTYDVHFYAS 550
FALIMLWPKL ELSLQYDMAL ATLREDLTRR RYLMSGVMAP VKRRNVIPHD 600
IGDPDDEPWL RVNAYLIHDT ADWKDLNLKF VLQVYRDYYL TGDQNFLKDM 650
WPVCLAVMES EMKFDKDHDG LIENGGYADQ TYDGWVTTGP SAYCGGLWLA 700
AVAVMVQMAA LCGAQDIQDK FSSILSRGQE AYERLLWNGR YYNYDSSSRP 750
QSRSVMSDQC AGQWFLKACG LGEGDTEVFP TQHVVRALQT IFELNVQAFA 800
GGAMGAVNGM QPHGVPDKSS VQSDEVWVGV VYGLAATMIQ EGLTWEGFQT 850
AEGCYRTVWE RLGLAFQTPE AYCQQRVFRS LAYMRPLSIW AMQLALQQQQ 900
HKKASWPKVK QGTGLRTGPM FGPKEAMANL SPE 933
Length:933
Mass (Da):105,301
Last modified:June 28, 2011 - v1
Checksum:i3E450FB6994E4F04
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL133410 Genomic DNA. No translation available.
RefSeqiXP_006716872.1. XM_006716809.1.
UniGeneiHs.443134.

Genome annotation databases

EnsembliENST00000545786; ENSP00000442372; ENSG00000070610.
GeneIDi57704.
KEGGihsa:57704.
UCSCiuc011lpd.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL133410 Genomic DNA. No translation available.
RefSeqi XP_006716872.1. XM_006716809.1.
UniGenei Hs.443134.

3D structure databases

ProteinModelPortali F5H7P6.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F5H7P6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000545786 ; ENSP00000442372 ; ENSG00000070610 .
GeneIDi 57704.
KEGGi hsa:57704.
UCSCi uc011lpd.2. human.

Organism-specific databases

CTDi 57704.
HGNCi HGNC:18986. GBA2.
GenAtlasi Search...

Phylogenomic databases

KOi K17108.
OMAi YQLPGQN.
PhylomeDBi F5H7P6.

Miscellaneous databases

ChiTaRSi GBA2. human.
GenomeRNAii 57704.
NextBioi 35509424.

Gene expression databases

ArrayExpressi F5H7P6.
Bgeei F5H7P6.

Family and domain databases

InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR014551. Beta_glucosidase_GBA2-type.
IPR024462. GBA2_N.
IPR006775. Glucosylceramidase.
[Graphical view ]
Pfami PF04685. DUF608. 1 hit.
PF12215. GBA2_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF028944. Beta_gluc_GBA2. 1 hit.
SUPFAMi SSF48208. SSF48208. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H7P6_HUMAN
AccessioniPrimary (citable) accession number: F5H7P6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 3, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi