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F5H7P6 (F5H7P6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length933 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide By similarity. PIRNR PIRNR028944

Catalytic activity

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. PIRNR PIRNR028944

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note: Not localized to lipid rafts By similarity. PIRNR PIRNR028944

Sequence similarities

Belongs to the non-lysosomal glucosylceramidase family. PIRNR PIRNR028944

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000442372

Sequences

Sequence LengthMass (Da)Tools
F5H7P6 [UniParc].

Last modified June 28, 2011. Version 1.
Checksum: 3E450FB6994E4F04

FASTA933105,301
        10         20         30         40         50         60 
MGTQDPGNMG TGVPASEQIS CAKEDPQVYC PEETGGTKDV QVTDCKSPED SRPPKETDCC 

        70         80         90        100        110        120 
NPEDSGQLMV SYEGKAMGYQ VPPFGWRICL AHEFTEKRKP FQANNVSLSN MIKHIGMGLR 

       130        140        150        160        170        180 
YLQWWYRKTH VEKKTPFIDM INSVPLRQIY GCPLGGIGGG TITRGWRGQF CRWQLNPGMY 

       190        200        210        220        230        240 
QHRTVIADQP ICPLKFTVCL RREGQTVYQQ VLSLERPSVL RSWNWGLCGY FAFYHALYPR 

       250        260        270        280        290        300 
AWTVYQLPGQ NVTLTCRQIT PILPHDYQDS SLPVGVFVWD VENEGDEALD VSIMFSMRNG 

       310        320        330        340        350        360 
LGGGDDAPGG LWNEPFCLER SGETVRGLLL HHPTLPNPYT MAVAARVTAA TTVTHITAFD 

       370        380        390        400        410        420 
PDSTGQQVWQ DLLQDGQLDS PTGQSTPTQK GVGIAGAVCV SSKLRPRGQC RLEFSLAWDM 

       430        440        450        460        470        480 
PRIMFGAKGQ VHYRRYTRFF GQDGDAAPAL SHYALCRYAE WEERISAWQS PVLDDRSLPA 

       490        500        510        520        530        540 
WYKSALFNEL YFLADGGTVW LEVLEDSLPE ELGRNMCHLR PTLRDYGRFG YLEGQEYRMY 

       550        560        570        580        590        600 
NTYDVHFYAS FALIMLWPKL ELSLQYDMAL ATLREDLTRR RYLMSGVMAP VKRRNVIPHD 

       610        620        630        640        650        660 
IGDPDDEPWL RVNAYLIHDT ADWKDLNLKF VLQVYRDYYL TGDQNFLKDM WPVCLAVMES 

       670        680        690        700        710        720 
EMKFDKDHDG LIENGGYADQ TYDGWVTTGP SAYCGGLWLA AVAVMVQMAA LCGAQDIQDK 

       730        740        750        760        770        780 
FSSILSRGQE AYERLLWNGR YYNYDSSSRP QSRSVMSDQC AGQWFLKACG LGEGDTEVFP 

       790        800        810        820        830        840 
TQHVVRALQT IFELNVQAFA GGAMGAVNGM QPHGVPDKSS VQSDEVWVGV VYGLAATMIQ 

       850        860        870        880        890        900 
EGLTWEGFQT AEGCYRTVWE RLGLAFQTPE AYCQQRVFRS LAYMRPLSIW AMQLALQQQQ 

       910        920        930 
HKKASWPKVK QGTGLRTGPM FGPKEAMANL SPE 

« Hide

References

« Hide 'large scale' references
[1]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL133410 Genomic DNA. No translation available.
UniGeneHs.443134.

3D structure databases

ProteinModelPortalF5H7P6.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEF5H7P6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000545786; ENSP00000442372; ENSG00000070610.
KEGGhsa:57704.
UCSCuc011lpd.2. human.

Organism-specific databases

CTD57704.
HGNCHGNC:18986. GBA2.
GenAtlasSearch...

Phylogenomic databases

KOK17108.
OMAYQLPGQN.

Gene expression databases

ArrayExpressF5H7P6.
BgeeF5H7P6.

Family and domain databases

InterProIPR008928. 6-hairpin_glycosidase-like.
IPR014551. Beta_glucosidase_GBA2-type.
IPR024462. GBA2_N.
IPR006775. Glucosylceramidase.
[Graphical view]
PfamPF04685. DUF608. 1 hit.
PF12215. GBA2_N. 1 hit.
[Graphical view]
PIRSFPIRSF028944. Beta_gluc_GBA2. 1 hit.
SUPFAMSSF48208. SSF48208. 1 hit.
ProtoNetSearch...

Other

ChiTaRSGBA2. human.
GenomeRNAi57704.
NextBio35509424.

Entry information

Entry nameF5H7P6_HUMAN
AccessionPrimary (citable) accession number: F5H7P6
Entry history
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.