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Protein
Submitted name:

Transducin-like enhancer protein 3

Gene

TLE3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiF5H7D6

Names & Taxonomyi

Protein namesi
Submitted name:
Transducin-like enhancer protein 3Imported
Gene namesi
Name:TLE3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140332.15
HGNCiHGNC:11839 TLE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140332

PTM / Processingi

Proteomic databases

EPDiF5H7D6
MaxQBiF5H7D6
PeptideAtlasiF5H7D6
PRIDEiF5H7D6

Expressioni

Gene expression databases

BgeeiENSG00000140332
ExpressionAtlasiF5H7D6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H7D6
SMRiF5H7D6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini409 – 582WD_REPEATS_REGIONInterPro annotationAdd BLAST174
Repeati499 – 540WDPROSITE-ProRule annotationAdd BLAST42
Repeati541 – 582WDPROSITE-ProRule annotationAdd BLAST42
Domaini623 – 699WD_REPEATS_REGIONInterPro annotationAdd BLAST77

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0639 Eukaryota
ENOG410XPX3 LUCA
GeneTreeiENSGT00550000074465

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR005617 Groucho/TLE_N
IPR009146 Groucho_enhance
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF03920 TLE_N, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR01850 GROUCHOFAMLY
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

F5H7D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYGLNIEMH KQTEIAKRLN TILAQIMPFL SQEHQQQVAQ AVERAKQVTM
60 70 80 90 100
TELNAIIGVR GLPNLPLTQQ QLQAQHLSHA THGPPVQLPP HPSGLQPPGI
110 120 130 140 150
PPVTGSSSGL LALGALGSQA HLTVKDEKNH HELDHRERES SANNSVSPSE
160 170 180 190 200
SLRASEKHRG SADYSMEAKK RKAEEKDSLS RYDSDGDKSD DLVVDVSNED
210 220 230 240 250
PATPRVSPAH SPPENGLDKA RSLKKDAPTS PASVASSSST PSSKTKDLGH
260 270 280 290 300
NDKSSTPGLK SNTPTPRNDA PTPGTSTTPG LRSMPASALR TPISITSSYA
310 320 330 340 350
APFAMMSHHE MNGSLTSPGA YAGLHNIPPQ MSAAAAAAAA AYGRSPMVGF
360 370 380 390 400
DPHPPMRATG LPSSLASIPG GKPAYSFHVS ADGQMQPVPF PHDALAGPGI
410 420 430 440 450
PRHARQINTL SHGEVVCAVT ISNPTRHVYT GGKGCVKIWD ISQPGSKSPI
460 470 480 490 500
SQLDCLNRDN YIRSCKLLPD GRTLIVGGEA STLTIWDLAS PTPRIKAELT
510 520 530 540 550
SSAPACYALA ISPDAKVCFS CCSDGNIAVW DLHNQTLVRQ FQGHTDGASC
560 570 580 590 600
IDISHDGTKL WTGGLDNTVR SWDLREGRQL QQHDFTSQIF SLGYCPTGEW
610 620 630 640 650
LAVGMESSNV EVLHHTKPDK YQLHLHESCV LSLKFAYCGK WFVSTGKDNL
660 670 680 690
LNAWRTPYGA SIFQSKESSS VLSCDISADD KYIVTGSGDK KATVYEVIY
Length:699
Mass (Da):74,901
Last modified:June 28, 2011 - v1
Checksum:i1D51CE8E9F722F86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026583 Genomic DNA No translation available.
AC068327 Genomic DNA No translation available.
RefSeqiNP_001269911.1, NM_001282982.1
UniGeneiHs.287362

Genome annotation databases

EnsembliENST00000539550; ENSP00000442594; ENSG00000140332
GeneIDi7090
UCSCiuc002ask.4 human

Similar proteinsi

Entry informationi

Entry nameiF5H7D6_HUMAN
AccessioniPrimary (citable) accession number: F5H7D6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 25, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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