Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Copper-transporting ATPase 2

Gene

ATP7B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi69PROSITE-ProRule annotation1
Metal bindingi72PROSITE-ProRule annotation1
Metal bindingi154PROSITE-ProRule annotation1
Metal bindingi157PROSITE-ProRule annotation1
Metal bindingi268PROSITE-ProRule annotation1
Metal bindingi271PROSITE-ProRule annotation1
Metal bindingi370PROSITE-ProRule annotation1
Metal bindingi373PROSITE-ProRule annotation1
Metal bindingi499PROSITE-ProRule annotation1
Metal bindingi502PROSITE-ProRule annotation1
Metal bindingi575PROSITE-ProRule annotation1
Metal bindingi578PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Copper-transporting ATPase 2Imported
Gene namesi
Name:ATP7BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:870. ATP7B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei654 – 673HelicalSequence analysisAdd BLAST20
Transmembranei693 – 715HelicalSequence analysisAdd BLAST23
Transmembranei727 – 753HelicalSequence analysisAdd BLAST27
Transmembranei923 – 950HelicalSequence analysisAdd BLAST28
Transmembranei1260 – 1282HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000123191.

PTM / Processingi

Proteomic databases

MaxQBiF5H748.
PaxDbiF5H748.
PeptideAtlasiF5H748.
PRIDEiF5H748.

Expressioni

Gene expression databases

BgeeiENSG00000123191.
ExpressionAtlasiF5H748. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H748.
SMRiF5H748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 125HMAInterPro annotationAdd BLAST67
Domaini144 – 210HMAInterPro annotationAdd BLAST67
Domaini258 – 327HMAInterPro annotationAdd BLAST70
Domaini360 – 426HMAInterPro annotationAdd BLAST67
Domaini489 – 555HMAInterPro annotationAdd BLAST67
Domaini565 – 631HMAInterPro annotationAdd BLAST67

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0207. Eukaryota.
COG2217. LUCA.
GeneTreeiENSGT00530000063773.

Family and domain databases

CDDicd00371. HMA. 6 hits.
Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00403. HMA. 6 hits.
SUPFAMiSSF55008. SSF55008. 6 hits.
SSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR00003. TIGR00003. 6 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 6 hits.
PS50846. HMA_2. 6 hits.

Sequencei

Sequence statusi: Complete.

F5H748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQERQITA REGASRKILS KLSLPTRAWE PAMKKSFAFD NVGYEGGLDG
60 70 80 90 100
LGPSSQVATS TVRILGMTCQ SCVKSIEDRI SNLKGIISMK VSLEQGSATV
110 120 130 140 150
KYVPSVVCLQ QVCHQIGDMG FEASIAEGKA ASWPSRSLPA QEAVVKLRVE
160 170 180 190 200
GMTCQSCVSS IEGKVRKLQG VVRVKVSLSN QEAVITYQPY LIQPEDLRDH
210 220 230 240 250
VNDMGFEAAI KSKVAPLSLG PIDIERLQST NPKRPLSSAN QNFNNSETLG
260 270 280 290 300
HQGSHVVTLQ LRIDGMHCKS CVLNIEENIG QLLGVQSIQV SLENKTAQVK
310 320 330 340 350
YDPSCTSPVA LQRAIEALPP GNFKVSLPDG AEGSGTDHRS SSSHSPGSPP
360 370 380 390 400
RNQVQGTCST TLIAIAGMTC ASCVHSIEGM ISQLEGVQQI SVSLAEGTAT
410 420 430 440 450
VLYNPSVISP EELRAAIEDM GFEASVVSES CSTNPLGNHS AGNSMVQTTD
460 470 480 490 500
GTPTSVQEVA PHTGRLPANH APDILAKSPQ STRAVAPQKC FLQIKGMTCA
510 520 530 540 550
SCVSNIERNL QKEAGVLSVL VALMAGKAEI KYDPEVIQPL EIAQFIQDLG
560 570 580 590 600
FEAAVMEDYA GSDGNIELTI TGMTCASCVH NIESKLTRTN GITYASVALA
610 620 630 640 650
TSKALVKFDP EIIGPRDIIK IIEEIGFHAS LAQRNPNAHH LDHKMEIKQW
660 670 680 690 700
KKSFLCSLVF GIPVMALMIY MLIPSNEPHQ SMVLDHNIIP GLSILNLIFF
710 720 730 740 750
ILCTFVQLLG GWYFYVQAYK SLRHRSANMD VLIVLATSIA YVYSLVILVV
760 770 780 790 800
AVAEKAERSP VTFFDTPPML FVFIALGRWL EHLAKSKTSE ALAKLMSLQA
810 820 830 840 850
TEATVVTLGE DNLIIREEQV PMELVQRGDI VKVVPGGKFP VDGKVLEGNT
860 870 880 890 900
MADESLITGE AMPVTKKPGS TVIAGSINAH GSVLIKATHV GNDTTLAQIV
910 920 930 940 950
KLVEEAQMSK APIQQLADRF SGYFVPFIII MSTLTLVVWI VIGFIDFGVV
960 970 980 990 1000
QRYFPIKTVM FDKTGTITHG VPRVMRVLLL GDVATLPLRK VLAVVGTAEA
1010 1020 1030 1040 1050
SSEHPLGVAV TKYCKEELGT ETLGYCTDFQ AVPGCGIGCK VSNVEGILAH
1060 1070 1080 1090 1100
SERPLSAPAS HLNEAGSLPA EKDAVPQTFS VLIGNREWLR RNGLTISSDV
1110 1120 1130 1140 1150
SDAMTDHEMK GQTAILVAID GVLCGMIAIA DAVKQEAALA VHTLQSMGVD
1160 1170 1180 1190 1200
VVLITGDNRK TARAIATQVG INKVFAEVLP SHKVAKVQEL QNKGKKVAMV
1210 1220 1230 1240 1250
GDGVNDSPAL AQADMGVAIG TGTDVAIEAA DVVLIRNDLL DVVASIHLSK
1260 1270 1280 1290 1300
RTVRRIRINL VLALIYNLVG IPIAAGVFMP IGIVLQPWMG SAAMAASSVS
1310 1320 1330 1340 1350
VVLSSLQLKC YKKPDLERYE AQAHGHMKPL TASQVSVHIG MDDRWRDSPR
1360 1370 1380 1390 1400
ATPWDQVSYV SQVSLSSLTS DKPSRHSAAA DDDGDKWSLL LNGRDEEQYI
Length:1,400
Mass (Da):150,519
Last modified:June 28, 2011 - v1
Checksum:i62D706EFE21ECB0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138821 Genomic DNA. No translation available.
AL139082 Genomic DNA. No translation available.
AL162377 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000418097; ENSP00000393343; ENSG00000123191.
UCSCiuc010tgt.3. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF5H748_HUMAN
AccessioniPrimary (citable) accession number: F5H748
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 5, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported