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Protein
Submitted name:

Tumor necrosis factor receptor superfamily member 1A

Gene

TNFRSF1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily member 1AImported
Gene namesi
Name:TNFRSF1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000067182.7.
HGNCiHGNC:11916. TNFRSF1A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 31HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000067182.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 72PROSITE-ProRule annotation
Disulfide bondi84 ↔ 99PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiF5H6V7.
PaxDbiF5H6V7.
PeptideAtlasiF5H6V7.
PRIDEiF5H6V7.

Expressioni

Gene expression databases

BgeeiENSG00000067182.
ExpressionAtlasiF5H6V7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H6V7.
SMRiF5H6V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 81TNFR-CysInterPro annotationAdd BLAST39
Repeati43 – 81TNFR-CysPROSITE-ProRule annotationAdd BLAST39
Domaini83 – 125TNFR-CysInterPro annotationAdd BLAST43
Repeati83 – 125TNFR-CysPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
GeneTreeiENSGT00530000064001.

Family and domain databases

CDDicd10576. TNFRSF1A. 1 hit.
InterProiView protein in InterPro
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
IPR033993. TNFRSF1A_N.
PfamiView protein in Pfam
PF00020. TNFR_c6. 2 hits.
PRINTSiPR01918. TNFACTORR1A.
SMARTiView protein in SMART
SM00208. TNFR. 3 hits.
PROSITEiView protein in PROSITE
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.

Sequencei

Sequence statusi: Fragment.

F5H6V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSTVPDLL LPLVLLELLV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI
60 70 80 90 100
HPQNNSICCT KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL
110 120 130 140 150
SCSKCRKEMG QVEISSCTVD RDTVCGCRKN QYRHYWSENL FQCFNCSLCL
160 170 180 190 200
NGTVHLSCER SSPEAKPSPH PRGWPLPHAV ALPFLPPPVF CGSDNQLLSG
210 220 230 240 250
RPHPVPRHFL CPVGWGCRRF SFSCAALLPT GQEKQNTVCT CHAGFFLREN

ECVS
Length:254
Mass (Da):28,137
Last modified:June 28, 2011 - v1
Checksum:i776D5DF878ABBF6F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei254Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006057 Genomic DNA. No translation available.
KF455591 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000440083; ENSP00000413224; ENSG00000067182.
UCSCiuc058kdd.1. human.

Similar proteinsi

Entry informationi

Entry nameiF5H6V7_HUMAN
AccessioniPrimary (citable) accession number: F5H6V7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported