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F5H6S1

- F5H6S1_HUMAN

UniProt

F5H6S1 - F5H6S1_HUMAN

Protein
Submitted name:

Lysine-specific demethylase 6A

Gene

KDM6A

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Lysine-specific demethylase 6AImported
    Gene namesi
    Name:KDM6AImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:12637. KDM6A.

    Expressioni

    Gene expression databases

    ArrayExpressiF5H6S1.
    BgeeiF5H6S1.

    Structurei

    3D structure databases

    ProteinModelPortaliF5H6S1.
    SMRiF5H6S1. Positions 108-378, 841-1350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains JmjC domain.SAAS annotation

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR003347. JmjC_dom.
    IPR029517. KDM6A.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR14017:SF9. PTHR14017:SF9. 1 hit.
    PfamiPF02373. JmjC. 1 hit.
    PF13181. TPR_8. 1 hit.
    [Graphical view]
    SMARTiSM00558. JmjC. 1 hit.
    SM00028. TPR. 6 hits.
    [Graphical view]
    PROSITEiPS51184. JMJC. 1 hit.
    PS50005. TPR. 7 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5H6S1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSCGVSLAT AAAAAAAFGD EEKKMAAGKA SGESEEASPS LTAEEREALG     50
    GLDSRLFGFV RFHEDGARTK ALLGKAVRCY ESLILKAEGK VESDFFCQLG 100
    HFNLLLEDYP KALSAYQRYY SLQSDYWKNA AFLYGLGLVY FHYNAFQWAI 150
    KAFQEVLYVD PSFCRAKEIH LRLGLMFKVN TDYESSLKHF QLALVDCNPC 200
    TLSNAEIQFH IAHLYETQRK YHSAKEAYEQ LLQTENLSAQ VKATVLQQLG 250
    WMHHTVDLLG DKATKESYAI QYLQKSLEAD PNSGQSWYFL GRCYSSIGKV 300
    QDAFISYRQS IDKSEASADT WCSIGVLYQQ QNQPMDALQA YICAVQLDHG 350
    HAAAWMDLGT LYESCNQPQD AIKCYLNATR SKSCSNTSAL AARIKYLQNT 400
    SDNWSGGHAV SHPPVQQQAH SWCLTPQKLQ HLEQLRANRN NLNPAQKLML 450
    EQLESQFVLM QQHQMRPTGV AQVRSTGIPN GPTADSSLPT NSVSGQQPQL 500
    ALTRVPSVSQ PGVRPACPGQ PLANGPFSAG HVPCSTSRTL GSTDTILIGN 550
    NHITGSGSNG NVPYLQRNAL TLPHNRTNLT SSAEEPWKNQ LSNSTQGLHK 600
    GQSSHSAGPN GERPLSSTGP SQHLQAAGSG IQNQNGHPTL PSNSVTQGAA 650
    LNHLSSHTAT SGGQQGITLT KESKPSGNIL TVPETSRHTG ETPNSTASVE 700
    GLPNHVHQMT ADAVCSPSHG DSKSPGLLSS DNPQLSALLM GKANNNVGTG 750
    TCDKVNNIHP AVHTKTDNSV ASSPSSAIST ATPSPKSTEQ TTTNSVTSLN 800
    SPHSGLHTIN GEGMEESQSP MKTDLLLVNH KPSPQIIPSM SVSIYPSSAE 850
    VLKACRNLGK NGLSNSSILL DKCPPPRPPS SPYPPLPKDK LNPPTPSIYL 900
    ENKRDAFFPP LHQFCTNPNN PVTVIRGLAG ALKLDLGLFS TKTLVEANNE 950
    HMVEVRTQLL QPADENWDPT GTKKIWHCES NRSHTTIAKY AQYQASSFQE 1000
    SLREENEKRS HHKDHSDSES TSSDNSGRRR KGPFKTIKFG TNIDLSDDKK 1050
    WKLQLHELTK LPAFVRVVSA GNLLSHVGHT ILGMNTVQLY MKVPGSRTPG 1100
    HQENNNFCSV NINIGPGDCE WFVVPEGYWG VLNDFCEKNN LNFLMGSWWP 1150
    NLEDLYEANV PVYRFIQRPG DLVWINAGTV HWVQAIGWCN NIAWNVGPLT 1200
    ACQYKLAVER YEWNKLQSVK SIVPMVHLSW NMARNIKVSD PKLFEMIKYC 1250
    LLRTLKQCQT LREALIAAGK EIIWHGRTKE EPAHYCSICE VEVFDLLFVT 1300
    NESNSRKTYI VHCQDCARKT SGNLENFVVL EQYKMEDLMQ VYDQFTLAPP 1350
    LPSASS 1356
    Length:1,356
    Mass (Da):149,317
    Last modified:June 28, 2011 - v1
    Checksum:iC2B91A66F2166107
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC136488 Genomic DNA. No translation available.
    AL133545 Genomic DNA. No translation available.
    AL138744 Genomic DNA. No translation available.
    KF510678 Genomic DNA. No translation available.
    RefSeqiNP_001278346.1. NM_001291417.1.
    UniGeneiHs.522616.

    Genome annotation databases

    EnsembliENST00000536777; ENSP00000437405; ENSG00000147050.
    GeneIDi7403.
    UCSCiuc011mla.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC136488 Genomic DNA. No translation available.
    AL133545 Genomic DNA. No translation available.
    AL138744 Genomic DNA. No translation available.
    KF510678 Genomic DNA. No translation available.
    RefSeqi NP_001278346.1. NM_001291417.1.
    UniGenei Hs.522616.

    3D structure databases

    ProteinModelPortali F5H6S1.
    SMRi F5H6S1. Positions 108-378, 841-1350.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000536777 ; ENSP00000437405 ; ENSG00000147050 .
    GeneIDi 7403.
    UCSCi uc011mla.2. human.

    Organism-specific databases

    HGNCi HGNC:12637. KDM6A.
    GenAtlasi Search...

    Miscellaneous databases

    ChiTaRSi KDM6A. human.
    GenomeRNAii 7403.
    NextBioi 35509241.

    Gene expression databases

    ArrayExpressi F5H6S1.
    Bgeei F5H6S1.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR003347. JmjC_dom.
    IPR029517. KDM6A.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR14017:SF9. PTHR14017:SF9. 1 hit.
    Pfami PF02373. JmjC. 1 hit.
    PF13181. TPR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00558. JmjC. 1 hit.
    SM00028. TPR. 6 hits.
    [Graphical view ]
    PROSITEi PS51184. JMJC. 1 hit.
    PS50005. TPR. 7 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF5H6S1_HUMAN
    AccessioniPrimary (citable) accession number: F5H6S1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3