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F5H6S1

- F5H6S1_HUMAN

UniProt

F5H6S1 - F5H6S1_HUMAN

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Protein
Submitted name:

Lysine-specific demethylase 6A

Gene

KDM6A

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. histone demethylase activity (H3-K27 specific) Source: InterPro
  2. metal ion binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine-specific demethylase 6AImported
Gene namesi
Name:KDM6AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:12637. KDM6A.

Expressioni

Gene expression databases

BgeeiF5H6S1.
ExpressionAtlasiF5H6S1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H6S1.
SMRiF5H6S1. Positions 108-378, 841-1350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains JmjC domain.SAAS annotation

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR003347. JmjC_dom.
IPR029517. KDM6A.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR14017:SF9. PTHR14017:SF9. 1 hit.
PfamiPF02373. JmjC. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H6S1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAGKASGES EEASPSLTAE EREALGGLDS RLFGFVRFHE DGARTKALLG
60 70 80 90 100
KAVRCYESLI LKAEGKVESD FFCQLGHFNL LLEDYPKALS AYQRYYSLQS
110 120 130 140 150
DYWKNAAFLY GLGLVYFHYN AFQWAIKAFQ EVLYVDPSFC RAKEIHLRLG
160 170 180 190 200
LMFKVNTDYE SSLKHFQLAL VDCNPCTLSN AEIQFHIAHL YETQRKYHSA
210 220 230 240 250
KEAYEQLLQT ENLSAQVKAT VLQQLGWMHH TVDLLGDKAT KESYAIQYLQ
260 270 280 290 300
KSLEADPNSG QSWYFLGRCY SSIGKVQDAF ISYRQSIDKS EASADTWCSI
310 320 330 340 350
GVLYQQQNQP MDALQAYICA VQLDHGHAAA WMDLGTLYES CNQPQDAIKC
360 370 380 390 400
YLNATRSKSC SNTSALAARI KYLQNTSDNW SGGHAVSHPP VQQQAHSWCL
410 420 430 440 450
TPQKLQHLEQ LRANRNNLNP AQKLMLEQLE SQFVLMQQHQ MRPTGVAQVR
460 470 480 490 500
STGIPNGPTA DSSLPTNSVS GQQPQLALTR VPSVSQPGVR PACPGQPLAN
510 520 530 540 550
GPFSAGHVPC STSRTLGSTD TILIGNNHIT GSGSNGNVPY LQRNALTLPH
560 570 580 590 600
NRTNLTSSAE EPWKNQLSNS TQGLHKGQSS HSAGPNGERP LSSTGPSQHL
610 620 630 640 650
QAAGSGIQNQ NGHPTLPSNS VTQGAALNHL SSHTATSGGQ QGITLTKESK
660 670 680 690 700
PSGNILTVPE TSRHTGETPN STASVEGLPN HVHQMTADAV CSPSHGDSKS
710 720 730 740 750
PGLLSSDNPQ LSALLMGKAN NNVGTGTCDK VNNIHPAVHT KTDNSVASSP
760 770 780 790 800
SSAISTATPS PKSTEQTTTN SVTSLNSPHS GLHTINGEGM EESQSPMKTD
810 820 830 840 850
LLLVNHKPSP QIIPSMSVSI YPSSAEVLKA CRNLGKNGLS NSSILLDKCP
860 870 880 890 900
PPRPPSSPYP PLPKDKLNPP TPSIYLENKR DAFFPPLHQF CTNPNNPVTV
910 920 930 940 950
IRGLAGALKL DLGLFSTKTL VEANNEHMVE VRTQLLQPAD ENWDPTGTKK
960 970 980 990 1000
IWHCESNRSH TTIAKYAQYQ ASSFQESLRE ENEKRSHHKD HSDSESTSSD
1010 1020 1030 1040 1050
NSGRRRKGPF KTIKFGTNID LSDDKKWKLQ LHELTKLPAF VRVVSAGNLL
1060 1070 1080 1090 1100
SHVGHTILGM NTVQLYMKVP GSRTPGHQEN NNFCSVNINI GPGDCEWFVV
1110 1120 1130 1140 1150
PEGYWGVLND FCEKNNLNFL MGSWWPNLED LYEANVPVYR FIQRPGDLVW
1160 1170 1180 1190 1200
INAGTVHWVQ AIGWCNNIAW NVGPLTACQY KLAVERYEWN KLQSVKSIVP
1210 1220 1230 1240 1250
MVHLSWNMAR NIKVSDPKLF EMIKYCLLRT LKQCQTLREA LIAAGKEIIW
1260 1270 1280 1290 1300
HGRTKEEPAH YCSICEVEVF DLLFVTNESN SRKTYIVHCQ DCARKTSGNL
1310 1320 1330
ENFVVLEQYK MEDLMQVYDQ FTLAPPLPSA SS
Length:1,332
Mass (Da):147,007
Last modified:October 29, 2014 - v2
Checksum:iB4911355F6B1AF9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC136488 Genomic DNA. No translation available.
AL133545 Genomic DNA. No translation available.
AL138744 Genomic DNA. No translation available.
KF510678 Genomic DNA. No translation available.
RefSeqiNP_001278346.1. NM_001291417.1.
UniGeneiHs.522616.

Genome annotation databases

EnsembliENST00000536777; ENSP00000437405; ENSG00000147050.
GeneIDi7403.
UCSCiuc011mla.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC136488 Genomic DNA. No translation available.
AL133545 Genomic DNA. No translation available.
AL138744 Genomic DNA. No translation available.
KF510678 Genomic DNA. No translation available.
RefSeqi NP_001278346.1. NM_001291417.1.
UniGenei Hs.522616.

3D structure databases

ProteinModelPortali F5H6S1.
SMRi F5H6S1. Positions 108-378, 841-1350.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000536777 ; ENSP00000437405 ; ENSG00000147050 .
GeneIDi 7403.
UCSCi uc011mla.2. human.

Organism-specific databases

CTDi 7403.
HGNCi HGNC:12637. KDM6A.
GenAtlasi Search...

Miscellaneous databases

ChiTaRSi KDM6A. human.
GenomeRNAii 7403.
NextBioi 35509241.

Gene expression databases

Bgeei F5H6S1.
ExpressionAtlasi F5H6S1. baseline and differential.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR003347. JmjC_dom.
IPR029517. KDM6A.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR14017:SF9. PTHR14017:SF9. 1 hit.
Pfami PF02373. JmjC. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view ]
SMARTi SM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view ]
PROSITEi PS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H6S1_HUMAN
AccessioniPrimary (citable) accession number: F5H6S1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: October 29, 2014
This is version 27 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3