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F5H6Q4

- F5H6Q4_HUMAN

UniProt

F5H6Q4 - F5H6Q4_HUMAN

Protein
Submitted name:

Transient receptor potential cation channel subfamily V member 4

Gene

TRPV4

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium channel activity Source: Ensembl
    2. osmosensor activity Source: Ensembl

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: Ensembl
    2. actin filament organization Source: Ensembl
    3. calcium ion import Source: Ensembl
    4. cell-cell junction assembly Source: Ensembl
    5. cellular hypotonic response Source: Ensembl
    6. cellular response to heat Source: Ensembl
    7. cortical microtubule organization Source: Ensembl
    8. hyperosmotic salinity response Source: Ensembl
    9. microtubule polymerization Source: Ensembl
    10. negative regulation of neuron projection development Source: Ensembl
    11. osmosensory signaling pathway Source: Ensembl
    12. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    13. positive regulation of microtubule depolymerization Source: Ensembl
    14. regulation of response to osmotic stress Source: Ensembl
    15. vasopressin secretion Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Transient receptor potential cation channel subfamily V member 4Imported
    Gene namesi
    Name:TRPV4Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:18083. TRPV4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cilium Source: Ensembl
    3. cortical actin cytoskeleton Source: Ensembl
    4. cytoplasmic microtubule Source: Ensembl
    5. cytoplasmic vesicle Source: Ensembl
    6. filopodium Source: Ensembl
    7. focal adhesion Source: Ensembl
    8. growth cone Source: Ensembl
    9. integral component of membrane Source: InterPro
    10. lamellipodium Source: Ensembl
    11. ruffle membrane Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiF5H6Q4.
    BgeeiF5H6Q4.

    Structurei

    3D structure databases

    ProteinModelPortaliF5H6Q4.
    SMRiF5H6Q4. Positions 148-552.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 ANK repeats.UniRule annotation

    Keywords - Domaini

    ANK repeatUniRule annotation, RepeatUniRule annotation

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR008347. TRPV1-4_channel.
    IPR008348. TRPV4_channel.
    [Graphical view]
    PANTHERiPTHR10582:SF4. PTHR10582:SF4. 1 hit.
    PfamiPF00023. Ank. 1 hit.
    [Graphical view]
    PRINTSiPR01768. TRPVRECEPTOR.
    PR01769. VRL2RECEPTOR.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5H6Q4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADSSEGPRA GPGEVAELPG DESGTPGGEA FPLSSLANLF EGEDGSLSPS    50
    PADASRPAGP GDGRPNLRMK FQGAFRKGVP NPIDLLESTL YESSVVPGPK 100
    KAPMDSLFDY GTYRHHSSDN KRWRKKIIEK QPQSPKAPAP QPPPILKVFN 150
    RPILFDIVSR GSTADLDGLL PFLLTHKKRL TDEEFREPST GKTCLPKALL 200
    NLSNGRNDTI PVLLDIAERT GNMREFINSP FRDIYYRGQT ALHIAIERRC 250
    KHYVELLVAQ GADVHAQARG RFFQPKDEGG YFYFGELPLS LAACTNQPHI 300
    VNYLTENPHK KADMRRQDSR GNTVLHALVA IADNTRENTK FVTKMYDLLL 350
    LKCARLFPDS NLEAVLNNDG LSPLMMAAKT GKIGIFQHII RREVTDEDTR 400
    HLSRKFKDWA YGPVYSSLYD LSSLDTCGEE ASVLEILVYN SKIENRHEML 450
    AVEPINELLR DKWRKFGAVS FYINVVSYLC AMVIFTLTAY YQPLEGTPPY 500
    PYRTTVDYLR LAGEVITLFT GVLFFFTNIK DLFMKKCPGV NSLFIDGSFQ 550
    LL 552
    Length:552
    Mass (Da):61,808
    Last modified:June 28, 2011 - v1
    Checksum:iA8502D6F55F129BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007834 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000538125; ENSP00000437449; ENSG00000111199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007834 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F5H6Q4.
    SMRi F5H6Q4. Positions 148-552.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000538125 ; ENSP00000437449 ; ENSG00000111199 .

    Organism-specific databases

    HGNCi HGNC:18083. TRPV4.
    GenAtlasi Search...

    Miscellaneous databases

    NextBioi 35509229.

    Gene expression databases

    ArrayExpressi F5H6Q4.
    Bgeei F5H6Q4.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR008347. TRPV1-4_channel.
    IPR008348. TRPV4_channel.
    [Graphical view ]
    PANTHERi PTHR10582:SF4. PTHR10582:SF4. 1 hit.
    Pfami PF00023. Ank. 1 hit.
    [Graphical view ]
    PRINTSi PR01768. TRPVRECEPTOR.
    PR01769. VRL2RECEPTOR.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF5H6Q4_HUMAN
    AccessioniPrimary (citable) accession number: F5H6Q4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3