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F5H6N9

- F5H6N9_HUMAN

UniProt

F5H6N9 - F5H6N9_HUMAN

Protein
Submitted name:

Pyrin

Gene

MEFV

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. inflammatory response Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    PyrinImported
    Gene namesi
    Name:MEFVImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:6998. MEFV.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Expressioni

    Gene expression databases

    ArrayExpressiF5H6N9.
    BgeeiF5H6N9.

    Structurei

    3D structure databases

    ProteinModelPortaliF5H6N9.
    SMRiF5H6N9. Positions 13-88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains DAPIN domain.SAAS annotation

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR004020. DAPIN.
    IPR011029. DEATH-like_dom.
    IPR029484. GVQW.
    IPR028841. Pyrin.
    IPR000315. Znf_B-box.
    [Graphical view]
    PANTHERiPTHR24103:SF264. PTHR24103:SF264. 1 hit.
    PfamiPF13900. GVQW. 1 hit.
    PF02758. PYRIN. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view]
    SMARTiSM00336. BBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50824. DAPIN. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5H6N9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKTPSDHLL STLEELVPYD FEKFKFKLQN TSVQKEHSRI PRSQIQRARP    50
    VKMATLLVTY YGEEYAVQLT LQVLRAINQR LLAEELHRAA IQEYSTQENG 100
    TDDSAASSSL GENKPRSLKT PDHPEGNEGN GPRPYGGGAA SLRCSQPEAG 150
    RGLSRKPLSK RREKASEGLD AQGKPRTRSP ALPGGRSPGP CRALEGGQAE 200
    VRLRRNASSA GRLQGLAGGA PGQKECRPFE VYLPSGKMRP RSLEVTISTG 250
    EKAPANPEIL LTLEEKTAAN LDSATEPRAR PTPDGGASAD LKEGPGNPEH 300
    SVTGRPPDTA ASPRCHAQEG DPVDGTCVRD SCSFPEAVSG HPQASGSRSP 350
    GCPRCQDSHE RKSPGSLSPQ PLPQCKRHLK QVQLLFCEDH DEPICLICSL 400
    SQEHQGHRVR PIEEVALEHK KKIQKQLEHL KKLRKSGEEQ RSYGEEKAVS 450
    FLVVVQWCDL GSLQPLPPGF KRFSCLSLLS SWDYRNKLKR 490
    Length:490
    Mass (Da):53,684
    Last modified:June 28, 2011 - v1
    Checksum:i4D272D3014F33D84
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ003147 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000538326; ENSP00000437486; ENSG00000103313.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ003147 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F5H6N9.
    SMRi F5H6N9. Positions 13-88.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000538326 ; ENSP00000437486 ; ENSG00000103313 .

    Organism-specific databases

    HGNCi HGNC:6998. MEFV.
    GenAtlasi Search...

    Miscellaneous databases

    NextBioi 35509218.

    Gene expression databases

    ArrayExpressi F5H6N9.
    Bgeei F5H6N9.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR004020. DAPIN.
    IPR011029. DEATH-like_dom.
    IPR029484. GVQW.
    IPR028841. Pyrin.
    IPR000315. Znf_B-box.
    [Graphical view ]
    PANTHERi PTHR24103:SF264. PTHR24103:SF264. 1 hit.
    Pfami PF13900. GVQW. 1 hit.
    PF02758. PYRIN. 1 hit.
    PF00643. zf-B_box. 1 hit.
    [Graphical view ]
    SMARTi SM00336. BBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50824. DAPIN. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF5H6N9_HUMAN
    AccessioniPrimary (citable) accession number: F5H6N9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3