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Protein

Beta-2-microglobulin

Gene

B2M

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulinSAAS annotation
Gene namesi
Name:B2MImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166710.17.
HGNCiHGNC:914. B2M.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MHC ISAAS annotation, SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166710.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501096244721 – 101Beta-2-microglobulinSequence analysisAdd BLAST81

Expressioni

Gene expression databases

BgeeiENSG00000166710.
ExpressionAtlasiF5H6I0. baseline and differential.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.SAAS annotation

Structurei

3D structure databases

SMRiF5H6I0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 92IGc1InterPro annotationAdd BLAST60

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00690000102227.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR015707. B2Microglobulin.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 2 hits.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

F5H6I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPADIEVD LLKNGERIEK
60 70 80 90 100
VEHSDLSFSK DWSFYLLYYT EFTPTEKDEY ACRVNHVTLS QPKIVKWDRD

M
Length:101
Mass (Da):11,732
Last modified:October 29, 2014 - v2
Checksum:i618597495A616CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018901 Genomic DNA. No translation available.
AC025270 Genomic DNA. No translation available.
AC122108 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000544417; ENSP00000437604; ENSG00000166710.
ENST00000619603; ENSP00000483449; ENSG00000273686.
UCSCiuc059iqm.1. human.

Similar proteinsi

Entry informationi

Entry nameiF5H6I0_HUMAN
AccessioniPrimary (citable) accession number: F5H6I0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: January 31, 2018
This is version 64 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported