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F5H5V6

- F5H5V6_HUMAN

UniProt

F5H5V6 - F5H5V6_HUMAN

Protein
Submitted name:

Lysine-specific demethylase 6A

Gene

KDM6A

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Lysine-specific demethylase 6AImported
    Gene namesi
    Name:KDM6AImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:12637. KDM6A.

    Expressioni

    Gene expression databases

    ArrayExpressiF5H5V6.
    BgeeiF5H5V6.

    Structurei

    3D structure databases

    ProteinModelPortaliF5H5V6.
    SMRiF5H5V6. Positions 108-378, 807-1316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains JmjC domain.SAAS annotation

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR003347. JmjC_dom.
    IPR029517. KDM6A.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR14017:SF9. PTHR14017:SF9. 1 hit.
    PfamiPF02373. JmjC. 1 hit.
    PF13181. TPR_8. 1 hit.
    [Graphical view]
    SMARTiSM00558. JmjC. 1 hit.
    SM00028. TPR. 6 hits.
    [Graphical view]
    PROSITEiPS51184. JMJC. 1 hit.
    PS50005. TPR. 7 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5H5V6-1 [UniParc]FASTAAdd to Basket

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    MKSCGVSLAT AAAAAAAFGD EEKKMAAGKA SGESEEASPS LTAEEREALG     50
    GLDSRLFGFV RFHEDGARTK ALLGKAVRCY ESLILKAEGK VESDFFCQLG 100
    HFNLLLEDYP KALSAYQRYY SLQSDYWKNA AFLYGLGLVY FHYNAFQWAI 150
    KAFQEVLYVD PSFCRAKEIH LRLGLMFKVN TDYESSLKHF QLALVDCNPC 200
    TLSNAEIQFH IAHLYETQRK YHSAKEAYEQ LLQTENLSAQ VKATVLQQLG 250
    WMHHTVDLLG DKATKESYAI QYLQKSLEAD PNSGQSWYFL GRCYSSIGKV 300
    QDAFISYRQS IDKSEASADT WCSIGVLYQQ QNQPMDALQA YICAVQLDHG 350
    HAAAWMDLGT LYESCNQPQD AIKCYLNATR SKSCSNTSAL AARIKYLQNT 400
    SDNWSGGHAV SHPPVQQQAH SWCLTPQKLQ MRPTGVAQVR STGIPNGPTA 450
    DSSLPTNSVS GQQPQLALTR VPSVSQPGVR PACPGQPLAN GPFSAGHVPC 500
    STSRTLGSTD TILIGNNHIT GSGSNGNVPY LQRNALTLPH NRTNLTSSAE 550
    EPWKNQLSNS TQGLHKGQSS HSAGPNGERP LSSTGPSQHL QAAGSGIQNQ 600
    NGHPTLPSNS VTQGAALNHL SSHTATSGGQ QGITLTKESK PSGNILTVPE 650
    TSRHTGETPN STASVEGLPN HVHQMTADAV CSPSHGDSKS PGLLSSDNPQ 700
    LSALLMGKAN NNVGTGTCDK VNNIHPAVHT KTDNSVASSP SSAISTATPS 750
    PKSTEQTTTN SVTSLNSPHS GLHTINGEGM EESQSPMKTD LLLVNHKPSP 800
    QIIPSMSVSI YPSSAEVLKA CRNLGKNGLS NSSILLDKCP PPRPPSSPYP 850
    PLPKDKLNPP TPSIYLENKR DAFFPPLHQF CTNPNNPVTV IRGLAGALKL 900
    DLGLFSTKTL VEANNEHMVE VRTQLLQPAD ENWDPTGTKK IWHCESNRSH 950
    TTIAKYAQYQ ASSFQESLRE ENEKRSHHKD HSDSESTSSD NSGRRRKGPF 1000
    KTIKFGTNID LSDDKKWKLQ LHELTKLPAF VRVVSAGNLL SHVGHTILGM 1050
    NTVQLYMKVP GSRTPGHQEN NNFCSVNINI GPGDCEWFVV PEGYWGVLND 1100
    FCEKNNLNFL MGSWWPNLED LYEANVPVYR FIQRPGDLVW INAGTVHWVQ 1150
    AIGWCNNIAW NVGPLTACQY KLAVERYEWN KLQSVKSIVP MVHLSWNMAR 1200
    NIKVSDPKLF EMIKYCLLRT LKQCQTLREA LIAAGKEIIW HGRTKEEPAH 1250
    YCSICEVEVF DLLFVTNESN SRKTYIVHCQ DCARKTSGNL ENFVVLEQYK 1300
    MEDLMQVYDQ FTLAPPLPSA SS 1322
    Length:1,322
    Mass (Da):145,234
    Last modified:June 28, 2011 - v1
    Checksum:iD1AD928C3F65403D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC136488 Genomic DNA. No translation available.
    AL133545 Genomic DNA. No translation available.
    AL138744 Genomic DNA. No translation available.
    KF510678 Genomic DNA. No translation available.
    RefSeqiNP_001278347.1. NM_001291418.1.
    UniGeneiHs.522616.

    Genome annotation databases

    EnsembliENST00000543216; ENSP00000443078; ENSG00000147050.
    GeneIDi7403.
    UCSCiuc022bvj.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC136488 Genomic DNA. No translation available.
    AL133545 Genomic DNA. No translation available.
    AL138744 Genomic DNA. No translation available.
    KF510678 Genomic DNA. No translation available.
    RefSeqi NP_001278347.1. NM_001291418.1.
    UniGenei Hs.522616.

    3D structure databases

    ProteinModelPortali F5H5V6.
    SMRi F5H5V6. Positions 108-378, 807-1316.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000543216 ; ENSP00000443078 ; ENSG00000147050 .
    GeneIDi 7403.
    UCSCi uc022bvj.1. human.

    Organism-specific databases

    HGNCi HGNC:12637. KDM6A.
    GenAtlasi Search...

    Miscellaneous databases

    ChiTaRSi KDM6A. human.
    GenomeRNAii 7403.
    NextBioi 35509074.

    Gene expression databases

    ArrayExpressi F5H5V6.
    Bgeei F5H5V6.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR003347. JmjC_dom.
    IPR029517. KDM6A.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR14017:SF9. PTHR14017:SF9. 1 hit.
    Pfami PF02373. JmjC. 1 hit.
    PF13181. TPR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00558. JmjC. 1 hit.
    SM00028. TPR. 6 hits.
    [Graphical view ]
    PROSITEi PS51184. JMJC. 1 hit.
    PS50005. TPR. 7 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF5H5V6_HUMAN
    AccessioniPrimary (citable) accession number: F5H5V6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3