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Protein
Submitted name:

Lysine-specific demethylase 6A

Gene

KDM6A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine-specific demethylase 6AImported
Gene namesi
Name:KDM6AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147050.14
HGNCiHGNC:12637 KDM6A

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147050

PTM / Processingi

Proteomic databases

EPDiF5H5V6
PeptideAtlasiF5H5V6
PRIDEiF5H5V6

Expressioni

Gene expression databases

BgeeiENSG00000147050
ExpressionAtlasiF5H5V6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H5V6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 361TPR_REGIONInterPro annotationAdd BLAST293
Repeati69 – 102TPRPROSITE-ProRule annotationAdd BLAST34
Repeati106 – 139TPRPROSITE-ProRule annotationAdd BLAST34
Repeati181 – 214TPRPROSITE-ProRule annotationAdd BLAST34
Repeati226 – 259TPRPROSITE-ProRule annotationAdd BLAST34
Repeati260 – 293TPRPROSITE-ProRule annotationAdd BLAST34
Repeati294 – 327TPRPROSITE-ProRule annotationAdd BLAST34
Repeati328 – 361TPRPROSITE-ProRule annotationAdd BLAST34
Domaini1044 – 1207JmjCInterPro annotationAdd BLAST164

Keywords - Domaini

TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00410000025758

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR003347 JmjC_dom
IPR029516 KDM6C
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR14017:SF9 PTHR14017:SF9, 3 hits
PfamiView protein in Pfam
PF02373 JmjC, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00558 JmjC, 1 hit
SM00028 TPR, 6 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS51184 JMJC, 1 hit
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

F5H5V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGKASGES EEASPSLTAE EREALGGLDS RLFGFVRFHE DGARTKALLG
60 70 80 90 100
KAVRCYESLI LKAEGKVESD FFCQLGHFNL LLEDYPKALS AYQRYYSLQS
110 120 130 140 150
DYWKNAAFLY GLGLVYFHYN AFQWAIKAFQ EVLYVDPSFC RAKEIHLRLG
160 170 180 190 200
LMFKVNTDYE SSLKHFQLAL VDCNPCTLSN AEIQFHIAHL YETQRKYHSA
210 220 230 240 250
KEAYEQLLQT ENLSAQVKAT VLQQLGWMHH TVDLLGDKAT KESYAIQYLQ
260 270 280 290 300
KSLEADPNSG QSWYFLGRCY SSIGKVQDAF ISYRQSIDKS EASADTWCSI
310 320 330 340 350
GVLYQQQNQP MDALQAYICA VQLDHGHAAA WMDLGTLYES CNQPQDAIKC
360 370 380 390 400
YLNATRSKSC SNTSALAARI KYLQACKPHH PNTEPVLGLS QTPISQQSLP
410 420 430 440 450
LHMIPSSQVD DLSSPAKRKR TSSPTKNTSD NWSGGHAVSH PPVQQQAHSW
460 470 480 490 500
CLTPQKLQMR PTGVAQVRST GIPNGPTADS SLPTNSVSGQ QPQLALTRVP
510 520 530 540 550
SVSQPGVRPA CPGQPLANGP FSAGHVPCST SRTLGSTDTI LIGNNHITGS
560 570 580 590 600
GSNGNVPYLQ RNALTLPHNR TNLTSSAEEP WKNQLSNSTQ GLHKGQSSHS
610 620 630 640 650
AGPNGERPLS STGPSQHLQA AGSGIQNQNG HPTLPSNSVT QGAALNHLSS
660 670 680 690 700
HTATSGGQQG ITLTKESKPS GNILTVPETS RHTGETPNST ASVEGLPNHV
710 720 730 740 750
HQMTADAVCS PSHGDSKSPG LLSSDNPQLS ALLMGKANNN VGTGTCDKVN
760 770 780 790 800
NIHPAVHTKT DNSVASSPSS AISTATPSPK STEQTTTNSV TSLNSPHSGL
810 820 830 840 850
HTINGEGMEE SQSPMKTDLL LVNHKPSPQI IPSMSVSIYP SSAEVLKACR
860 870 880 890 900
NLGKNGLSNS SILLDKCPPP RPPSSPYPPL PKDKLNPPTP SIYLENKRDA
910 920 930 940 950
FFPPLHQFCT NPNNPVTVIR GLAGALKLDL GLFSTKTLVE ANNEHMVEVR
960 970 980 990 1000
TQLLQPADEN WDPTGTKKIW HCESNRSHTT IAKYAQYQAS SFQESLREEN
1010 1020 1030 1040 1050
EKRSHHKDHS DSESTSSDNS GRRRKGPFKT IKFGTNIDLS DDKKWKLQLH
1060 1070 1080 1090 1100
ELTKLPAFVR VVSAGNLLSH VGHTILGMNT VQLYMKVPGS RTPGHQENNN
1110 1120 1130 1140 1150
FCSVNINIGP GDCEWFVVPE GYWGVLNDFC EKNNLNFLMG SWWPNLEDLY
1160 1170 1180 1190 1200
EANVPVYRFI QRPGDLVWIN AGTVHWVQAI GWCNNIAWNV GPLTACQYKL
1210 1220 1230 1240 1250
AVERYEWNKL QSVKSIVPMV HLSWNMARNI KVLSSKNSEA MSDIEGSSHC
1260
CRKRDYMAWA DKRRTSSLL
Length:1,269
Mass (Da):139,147
Last modified:October 29, 2014 - v2
Checksum:iAFF1589AE823DE5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136488 Genomic DNA No translation available.
AL133545 Genomic DNA No translation available.
AL138744 Genomic DNA No translation available.
KF510678 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000543216; ENSP00000443078; ENSG00000147050
UCSCiuc064yrw.1 human

Similar proteinsi

Entry informationi

Entry nameiF5H5V6_HUMAN
AccessioniPrimary (citable) accession number: F5H5V6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: May 23, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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