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Protein
Submitted name:

Lysine-specific demethylase 6A

Gene

KDM6A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. histone demethylase activity (H3-K27 specific) Source: InterPro
  2. metal ion binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Lysine-specific demethylase 6AImported
Gene namesi
Name:KDM6AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12637. KDM6A.

Expressioni

Gene expression databases

BgeeiF5H5V6.

Structurei

3D structure databases

SMRiF5H5V6. Positions 835-1263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains JmjC domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00410000025758.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR003347. JmjC_dom.
IPR029517. KDM6A.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR14017:SF9. PTHR14017:SF9. 1 hit.
PfamiPF02373. JmjC. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H5V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGKASGES EEASPSLTAE EREALGGLDS RLFGFVRFHE DGARTKALLG
60 70 80 90 100
KAVRCYESLI LKAEGKVESD FFCQLGHFNL LLEDYPKALS AYQRYYSLQS
110 120 130 140 150
DYWKNAAFLY GLGLVYFHYN AFQWAIKAFQ EVLYVDPSFC RAKEIHLRLG
160 170 180 190 200
LMFKVNTDYE SSLKHFQLAL VDCNPCTLSN AEIQFHIAHL YETQRKYHSA
210 220 230 240 250
KEAYEQLLQT ENLSAQVKAT VLQQLGWMHH TVDLLGDKAT KESYAIQYLQ
260 270 280 290 300
KSLEADPNSG QSWYFLGRCY SSIGKVQDAF ISYRQSIDKS EASADTWCSI
310 320 330 340 350
GVLYQQQNQP MDALQAYICA VQLDHGHAAA WMDLGTLYES CNQPQDAIKC
360 370 380 390 400
YLNATRSKSC SNTSALAARI KYLQACKPHH PNTEPVLGLS QTPISQQSLP
410 420 430 440 450
LHMIPSSQVD DLSSPAKRKR TSSPTKNTSD NWSGGHAVSH PPVQQQAHSW
460 470 480 490 500
CLTPQKLQMR PTGVAQVRST GIPNGPTADS SLPTNSVSGQ QPQLALTRVP
510 520 530 540 550
SVSQPGVRPA CPGQPLANGP FSAGHVPCST SRTLGSTDTI LIGNNHITGS
560 570 580 590 600
GSNGNVPYLQ RNALTLPHNR TNLTSSAEEP WKNQLSNSTQ GLHKGQSSHS
610 620 630 640 650
AGPNGERPLS STGPSQHLQA AGSGIQNQNG HPTLPSNSVT QGAALNHLSS
660 670 680 690 700
HTATSGGQQG ITLTKESKPS GNILTVPETS RHTGETPNST ASVEGLPNHV
710 720 730 740 750
HQMTADAVCS PSHGDSKSPG LLSSDNPQLS ALLMGKANNN VGTGTCDKVN
760 770 780 790 800
NIHPAVHTKT DNSVASSPSS AISTATPSPK STEQTTTNSV TSLNSPHSGL
810 820 830 840 850
HTINGEGMEE SQSPMKTDLL LVNHKPSPQI IPSMSVSIYP SSAEVLKACR
860 870 880 890 900
NLGKNGLSNS SILLDKCPPP RPPSSPYPPL PKDKLNPPTP SIYLENKRDA
910 920 930 940 950
FFPPLHQFCT NPNNPVTVIR GLAGALKLDL GLFSTKTLVE ANNEHMVEVR
960 970 980 990 1000
TQLLQPADEN WDPTGTKKIW HCESNRSHTT IAKYAQYQAS SFQESLREEN
1010 1020 1030 1040 1050
EKRSHHKDHS DSESTSSDNS GRRRKGPFKT IKFGTNIDLS DDKKWKLQLH
1060 1070 1080 1090 1100
ELTKLPAFVR VVSAGNLLSH VGHTILGMNT VQLYMKVPGS RTPGHQENNN
1110 1120 1130 1140 1150
FCSVNINIGP GDCEWFVVPE GYWGVLNDFC EKNNLNFLMG SWWPNLEDLY
1160 1170 1180 1190 1200
EANVPVYRFI QRPGDLVWIN AGTVHWVQAI GWCNNIAWNV GPLTACQYKL
1210 1220 1230 1240 1250
AVERYEWNKL QSVKSIVPMV HLSWNMARNI KVLSSKNSEA MSDIEGSSHC
1260
CRKRDYMAWA DKRRTSSLL
Length:1,269
Mass (Da):139,147
Last modified:October 28, 2014 - v2
Checksum:iAFF1589AE823DE5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136488 Genomic DNA. No translation available.
AL133545 Genomic DNA. No translation available.
AL138744 Genomic DNA. No translation available.
KF510678 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000543216; ENSP00000443078; ENSG00000147050.
UCSCiuc022bvj.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136488 Genomic DNA. No translation available.
AL133545 Genomic DNA. No translation available.
AL138744 Genomic DNA. No translation available.
KF510678 Genomic DNA. No translation available.

3D structure databases

SMRiF5H5V6. Positions 835-1263.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000543216; ENSP00000443078; ENSG00000147050.
UCSCiuc022bvj.1. human.

Organism-specific databases

CTDi7403.
HGNCiHGNC:12637. KDM6A.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00410000025758.

Miscellaneous databases

ChiTaRSiKDM6A. human.
GenomeRNAii7403.
NextBioi35509074.

Gene expression databases

BgeeiF5H5V6.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR003347. JmjC_dom.
IPR029517. KDM6A.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR14017:SF9. PTHR14017:SF9. 1 hit.
PfamiPF02373. JmjC. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
PS50005. TPR. 7 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:ra46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H5V6_HUMAN
AccessioniPrimary (citable) accession number: F5H5V6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 27, 2011
Last sequence update: October 28, 2014
Last modified: March 31, 2015
This is version 31 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationMaxQB annotation, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.