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F5H5U8

- F5H5U8_HUMAN

UniProt

F5H5U8 - F5H5U8_HUMAN

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Protein
Tyrosine-protein kinase
Gene
JAK2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: Ensembl
  2. STAT protein import into nucleus Source: Ensembl
  3. activation of MAPKK activity Source: Ensembl
  4. axon regeneration Source: Ensembl
  5. extrinsic apoptotic signaling pathway Source: Ensembl
  6. hormone-mediated signaling pathway Source: Ensembl
  7. host programmed cell death induced by symbiont Source: Ensembl
  8. interferon-gamma-mediated signaling pathway Source: Ensembl
  9. intrinsic apoptotic signaling pathway in response to oxidative stress Source: Ensembl
  10. mammary gland epithelium development Source: Ensembl
  11. mineralocorticoid receptor signaling pathway Source: Ensembl
  12. myeloid cell differentiation Source: Ensembl
  13. negative regulation of DNA binding Source: Ensembl
  14. negative regulation of cell proliferation Source: Ensembl
  15. negative regulation of cell-cell adhesion Source: Ensembl
  16. negative regulation of heart contraction Source: Ensembl
  17. negative regulation of neuron apoptotic process Source: Ensembl
  18. platelet-derived growth factor receptor signaling pathway Source: Ensembl
  19. positive regulation of DNA binding Source: Ensembl
  20. positive regulation of apoptotic process Source: Ensembl
  21. positive regulation of apoptotic signaling pathway Source: Ensembl
  22. positive regulation of cell activation Source: Ensembl
  23. positive regulation of cell differentiation Source: Ensembl
  24. positive regulation of cell migration Source: Ensembl
  25. positive regulation of cell proliferation Source: Ensembl
  26. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  27. positive regulation of inflammatory response Source: Ensembl
  28. positive regulation of insulin secretion Source: Ensembl
  29. positive regulation of interleukin-1 beta production Source: Ensembl
  30. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  31. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  32. positive regulation of phosphoprotein phosphatase activity Source: Ensembl
  33. positive regulation of protein import into nucleus, translocation Source: Ensembl
  34. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  35. response to hydroperoxide Source: Ensembl
  36. tyrosine phosphorylation of Stat1 protein Source: Ensembl
  37. tyrosine phosphorylation of Stat3 protein Source: Ensembl
  38. tyrosine phosphorylation of Stat5 protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiF5H5U8.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:JAK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:6192. JAK2.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. cytoskeleton Source: InterPro
  3. cytosol Source: Ensembl
  4. nuclear matrix Source: Ensembl
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Expressioni

Gene expression databases

ArrayExpressiF5H5U8.
BgeeiF5H5U8.

Structurei

3D structure databases

ProteinModelPortaliF5H5U8.
SMRiF5H5U8. Positions 3-983.

Family & Domainsi

Sequence similaritiesi

Contains 1 FERM domain.UniRule annotation
Contains 1 SH2 domain.UniRule annotation
Contains 4 protein kinase domains.UniRule annotation

Keywords - Domaini

SH2 domainUniRule annotation

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693. Tyr_kinase_non-rcpt_Jak2.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR01823. JANUSKINASE.
PR01825. JANUSKINASE2.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H5U8-1 [UniParc]FASTAAdd to Basket

« Hide

MSYLFAQWRH DFVHGWIKVP VTHETQEECL GMAVLDMMRI AKENDQTPLA    50
IYNSISYKTF LPKCIRAKIQ DYHILTRKRI RYRFRRFIQQ FSQCKATARN 100
LKLKYLINLE TLQSAFYTEK FEVKEPGSGP SGEEIFATII ITGNGGIQWS 150
RGKHKESETL TEQDLQLYCD FPNIIDVSIK QANQEGSNES RVVTIHKQDG 200
KNLEIELSSL REALSFVSLI DGYYRLTADA HHYLCKEVAP PAVLENIQSN 250
CHGPISMDFA ISKLKKAGNQ TGLYVLRCSP KDFNKYFLTF AVERENVIEY 300
KHCLITKNEN EEYNLSGTKK NFSSLKDLLN CYQMETVRSD NIIFQFTKCC 350
PPKPKDKSNL LVFRTNGVSD VPTSPTLQRP THMNQMVFHK IRNEDLIFNE 400
SLGQGTFTKI FKGVRREVGD YGQLHETEVL LKVLDKAHRN YSESFFEAAS 450
MMSKLSHKHL VLNYGVCVCG DENILVQEFV KFGSLDTYLK KNKNCINILW 500
KLEVAKQLAW AMHFLEENTL IHGNVCAKNI LLIREEDRKT GNPPFIKLSD 550
PGISITVLPK DILQERIPWV PPECIENPKN LNLATDKWSF GTTLWEICSG 600
GDKPLSALDS QRKLQFYEDR HQLPAPKWAE LANLINNCMD YEPDFRPSFR 650
AIIRDLNSLF TPDYELLTEN DMLPNMRIGA LGFSGAFEDR DPTQFEERHL 700
KFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTE EHLRDFEREI 750
EILKSLQHDN IVKYKGVCYS AGRRNLKLIM EYLPYGSLRD YLQKHKERID 800
HIKLLQYTSQ ICKGMEYLGT KRYIHRDLAT RNILVENENR VKIGDFGLTK 850
VLPQDKEYYK VKEPGESPIF WYAPESLTES KFSVASDVWS FGVVLYELFT 900
YIEKSKSPPA EFMRMIGNDK QGQMIVFHLI ELLKNNGRLP RPDGCPDEIY 950
MIMTECWNNN VNQRPSFRDL ALRVDQIRDN MAG 983
Length:983
Mass (Da):113,766
Last modified:June 28, 2011 - v1
Checksum:iF9C99B39A8A9D345
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL158147 Genomic DNA. No translation available.
AL161450 Genomic DNA. No translation available.
AL513350 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000544510; ENSP00000443103; ENSG00000096968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL158147 Genomic DNA. No translation available.
AL161450 Genomic DNA. No translation available.
AL513350 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F5H5U8.
SMRi F5H5U8. Positions 3-983.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000544510 ; ENSP00000443103 ; ENSG00000096968 .

Organism-specific databases

HGNCi HGNC:6192. JAK2.
GenAtlasi Search...

Enzyme and pathway databases

SignaLinki F5H5U8.

Miscellaneous databases

ChiTaRSi JAK2. human.
NextBioi 35509070.

Gene expression databases

ArrayExpressi F5H5U8.
Bgeei F5H5U8.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020693. Tyr_kinase_non-rcpt_Jak2.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 2 hits.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR01823. JANUSKINASE.
PR01825. JANUSKINASE2.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H5U8_HUMAN
AccessioniPrimary (citable) accession number: F5H5U8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi