F5H5M9 (F5H5M9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
TRAF2 and NCK-interacting protein kinase Ensembl ENSP00000443278

Gene names

Name:

TNIK Ensembl ENSP00000443278

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000443278

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000443278

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro small GTPase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F5H5M9 [UniParc]. Last modified June 28, 2011. Version 1. Checksum: 37B58562A3E9176D	FASTA	1,312	149,621
	10 20 30 40 50 60 MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 70 80 90 100 110 120 DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 130 140 150 160 170 180 KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKIV DFGVSAQLDR 190 200 210 220 230 240 TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 250 260 270 280 290 300 ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 310 320 330 340 350 360 QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 370 380 390 400 410 420 NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 430 440 450 460 470 480 REQRRHYEEQ MRREEERRRA EHEQEYIRRQ LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL 490 500 510 520 530 540 EEQRQAERLQ RQLKQERDYL VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEIPHL 550 560 570 580 590 600 VAVKSQGPAL TASQSVHEQP TKGLSGFQEA LNVTSHRVEM PRQNSDPTSE NPPLPTRIEK 610 620 630 640 650 660 FDRSSWLRQE EDIPPKVPQR TTSISPALAR KNSPGNGSAL GPRLGSQPIR ASNPDLRRTE 670 680 690 700 710 720 PILESPLQRT SSGSSSSSST PSSQPSSQGG SQPGSQAGSS ERTRVRANSK SEGSPVLPHE 730 740 750 760 770 780 PAKVKPEESR DITRPSRPAV SAFLSKSFEL LIYQDLTALA KELRELRIEE TNRPMKKVTD 790 800 810 820 830 840 YSSSSEESES SEEEEEDGES ETHDGTVAVS DIPRLIPTGA PGSNEQYNVG MVGTHGLETS 850 860 870 880 890 900 HADSFSGSIS REGTLMIRET SGEKKRSGHS DSNGFAGHIN LPDLVQQSHS PAGTPTEGLG 910 920 930 940 950 960 RVSTHSQEMD SGTEYGMGSS TKASFTPFVD PRVYQTSPTD EDEEDEESSA AALFTSELLR 970 980 990 1000 1010 1020 QEQAKLNEAR KISVVNVNPT NIRPHSDTPE IRKYKKRFNS EILCAALWGV NLLVGTENGL 1030 1040 1050 1060 1070 1080 MLLDRSGQGK VYNLINRRRF QQMDVLEGLN VLVTISGKKN KLRVYYLSWL RNRILHNDPE 1090 1100 1110 1120 1130 1140 VEKKQGWITV GDLEGCIHYK VVKYERIKFL VIALKNAVEI YAWAPKPYHK FMAFKSFADL 1150 1160 1170 1180 1190 1200 QHKPLLVDLT VEEGQRLKVI FGSHTGFHVI DVDSGNSYDI YIPSHIQGNI TPHAIVILPK 1210 1220 1230 1240 1250 1260 TDGMEMLVCY EDEGVYVNTY GRITKDVVLQ WGEMPTSVAY IHSNQIMGWG EKAIEIRSVE 1270 1280 1290 1300 1310 TGHLDGVFMH KRAQRLKFLC ERNDKVFFAS VRSGGSSQVF FMTLNRNSMM NW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC026315 Genomic DNA. No translation available. AC078793 Genomic DNA. No translation available. AC092919 Genomic DNA. No translation available. AC137517 Genomic DNA. No translation available.
IPI	IPI00218907.
3D structure databases
ProteinModelPortal	F5H5M9.
SMR	F5H5M9. Positions 13-313.
ModBase	Search...
Proteomic databases
PRIDE	F5H5M9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000538048; ENSP00000443278; ENSG00000154310.
Organism-specific databases
HGNC	HGNC:30765. TNIK.
GenAtlas	Search...
Gene expression databases
ArrayExpress	F5H5M9.
Bgee	F5H5M9.
Family and domain databases
InterPro	IPR001180. Citron. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00780. CNH. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00036. CNH. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50219. CNH. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35509025.

Entry information

Entry name

F5H5M9_HUMAN

Accession

Primary (citable) accession number: F5H5M9

Entry history

Integrated into UniProtKB/TrEMBL:	June 28, 2011
Last sequence update:	June 28, 2011
Last modified:	April 3, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.