Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F5H538

- F5H538_HUMAN

UniProt

F5H538 - F5H538_HUMAN

Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 4

Gene

MAP3K4

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (28 Jun 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: InterPro

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiF5H538.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Mitogen-activated protein kinase kinase kinase 4Imported
    Gene namesi
    Name:MAP3K4Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6856. MAP3K4.

    Expressioni

    Gene expression databases

    ArrayExpressiF5H538.
    BgeeiF5H538.

    Structurei

    3D structure databases

    ProteinModelPortaliF5H538.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK04428.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F5H538-1 [UniParc]FASTAAdd to Basket

    « Hide

    MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA     50
    RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ 100
    RNNVGRPASR SNLKEKMNAP NQPPHKDTGK TVENVEEYSY KQEKKIRAAL 150
    RTTERDRKKN VQCSFMLDSV GGSLPKKSIP DVDLNKPYLS LGCSNAKLPV 200
    SVPMPIARPA RQTSRTDCPA DRLKFFETLR LLLKLTSVSK KKDREQRGQE 250
    NTSGFWLNRS NELIWLELQA WHAGRTINDQ DFFLYTARQA IPDIINEILT 300
    FKVDYGSFAF VRDRAGFNGT SVEGQCKATP GTKIVGYSTH HEHLQRQRVS 350
    FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT 400
    KDLNQKLRIM GTVLGIKNLS DIGWPVFEIP SPRPSKGNEP EYEGDDTEGE 450
    LKELESSTDE SEEEQISDPR VPEIRQPIDN SFDIQSRDCI SKKLERLESE 500
    DDSLGWGAPD WSTEAGFSRH CLTSIYRPFV DKALKQMGLR KLILRLHKLM 550
    DGSLQRARIA LVKNDRPVEF SEFPDPMWGS DYVQLSRTPP SSEEKCSAVS 600
    WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ 650
    LVRECKEVLK GGLLMKQYYQ FMLQEVLEDL EKPDCNIDAF EEDLHKMLMV 700
    YFDYMRSWIQ MLQQLPQASH SLKNLLEEEW NFTKEITHYI RGGEAQAGKL 750
    FCDIAGMLLK STGSFLEFGL QESCAEFWTS ADDSSASDEI RRSVIEISRA 800
    LKELFHEARE RASKALGFAK MLRKDLEIAA EFRLSAPVRD LLDVLKSKQY 850
    VKVQIPGLEN LQMFVPDTLA EEKSIILQLL NAAAGKDCSK DSDDVLIDAY 900
    LLLTKHGDRA RDSEDSWGTW EAQPVKVVPQ VETVDTLRSM QVDNLLLVVM 950
    QSAHLTIQRK AFQQSIEGLM TLCQEQTSSQ PVIAKALQQL KNDALELCNR 1000
    ISNAIDRVDH MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV 1050
    VRLMSGEFRQ KIGDKYISFA RKWMNYVLTK CESGRGTRPR WATQGFDFLQ 1100
    AIEPAFISAL PEDDFLSLQA LMNECIGHVI GKPHSPVTAI HRNSPRPMKV 1150
    PRCHSDPPNP HLIIPTPEGF STRSMPSDAR SHGSPAAAAA AAAAAVAASR 1200
    PSPSGGDSVL PKSISSAHDT RGSSVPENDR LASIAAELQF RSLSRHSSPT 1250
    EERDEPAYPR GDSSGSTRRS WELRTLISQS KDTASKLGPI EAIQKSVRLF 1300
    EEKRYREMRR KNIIGQVCDT PKSYDNVMHV GLRKVTFKWQ RGNKIGEGQY 1350
    GKVYTCISVD TGELMAMKEI RFQPNDHKTI KETADELKIF EGIKHPNLVR 1400
    YFGVELHREE MYIFMEYCDE GTLEEVSRLG LQEHVIRLYS KQITIAINVL 1450
    HEHGIVHRDI KGANIFLTSS GLIKLGDFGC SVKLKNNAQT MPGEVNSTLG 1500
    TAAYMAPEVI TRAKGEGHGR AADIWSLGCV VIEMVTGKRP WHEYEHNFQI 1550
    MYKVGMGHKP PIPERLSPEG KDFLSHCLES DPKMRWTASQ LLDHSFVKVC 1600
    TDEE 1604
    Length:1,604
    Mass (Da):181,238
    Last modified:June 28, 2011 - v1
    Checksum:i8E0307C6EBF24857
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL109942 Genomic DNA. No translation available.
    AL139393 Genomic DNA. No translation available.
    AL591045 Genomic DNA. No translation available.
    AL596452 Genomic DNA. No translation available.
    KF458343 Genomic DNA. No translation available.
    RefSeqiXP_005267045.1. XM_005266988.1.
    UniGeneiHs.390428.

    Genome annotation databases

    EnsembliENST00000366920; ENSP00000355887; ENSG00000085511.
    GeneIDi4216.
    KEGGihsa:4216.
    UCSCiuc010kkc.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL109942 Genomic DNA. No translation available.
    AL139393 Genomic DNA. No translation available.
    AL591045 Genomic DNA. No translation available.
    AL596452 Genomic DNA. No translation available.
    KF458343 Genomic DNA. No translation available.
    RefSeqi XP_005267045.1. XM_005266988.1.
    UniGenei Hs.390428.

    3D structure databases

    ProteinModelPortali F5H538.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366920 ; ENSP00000355887 ; ENSG00000085511 .
    GeneIDi 4216.
    KEGGi hsa:4216.
    UCSCi uc010kkc.2. human.

    Organism-specific databases

    CTDi 4216.
    HGNCi HGNC:6856. MAP3K4.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K04428.

    Enzyme and pathway databases

    SignaLinki F5H538.

    Miscellaneous databases

    ChiTaRSi MAP3K4. human.
    GenomeRNAii 4216.
    NextBioi 35508916.

    Gene expression databases

    ArrayExpressi F5H538.
    Bgeei F5H538.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiF5H538_HUMAN
    AccessioniPrimary (citable) accession number: F5H538
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 28, 2011
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3