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Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 4

Gene

MAP3K4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiF5H538.

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 4Imported
Gene namesi
Name:MAP3K4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6856. MAP3K4.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000085511.

PTM / Processingi

Proteomic databases

MaxQBiF5H538.
PaxDbiF5H538.
PRIDEiF5H538.

Expressioni

Gene expression databases

BgeeiENSG00000085511.
ExpressionAtlasiF5H538. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375986.

Structurei

3D structure databases

ProteinModelPortaliF5H538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1339 – 1597Protein kinaseInterPro annotationAdd BLAST259

Phylogenomic databases

eggNOGiKOG4645. Eukaryota.
ENOG410XQZE. LUCA.
GeneTreeiENSGT00590000083157.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA
60 70 80 90 100
RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ
110 120 130 140 150
RNNVGRPASR SNLKEKMNAP NQPPHKDTGK TVENVEEYSY KQEKKIRAAL
160 170 180 190 200
RTTERDRKKN VQCSFMLDSV GGSLPKKSIP DVDLNKPYLS LGCSNAKLPV
210 220 230 240 250
SVPMPIARPA RQTSRTDCPA DRLKFFETLR LLLKLTSVSK KKDREQRGQE
260 270 280 290 300
NTSGFWLNRS NELIWLELQA WHAGRTINDQ DFFLYTARQA IPDIINEILT
310 320 330 340 350
FKVDYGSFAF VRDRAGFNGT SVEGQCKATP GTKIVGYSTH HEHLQRQRVS
360 370 380 390 400
FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT
410 420 430 440 450
KDLNQKLRIM GTVLGIKNLS DIGWPVFEIP SPRPSKGNEP EYEGDDTEGE
460 470 480 490 500
LKELESSTDE SEEEQISDPR VPEIRQPIDN SFDIQSRDCI SKKLERLESE
510 520 530 540 550
DDSLGWGAPD WSTEAGFSRH CLTSIYRPFV DKALKQMGLR KLILRLHKLM
560 570 580 590 600
DGSLQRARIA LVKNDRPVEF SEFPDPMWGS DYVQLSRTPP SSEEKCSAVS
610 620 630 640 650
WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ
660 670 680 690 700
LVRECKEVLK GGLLMKQYYQ FMLQEVLEDL EKPDCNIDAF EEDLHKMLMV
710 720 730 740 750
YFDYMRSWIQ MLQQLPQASH SLKNLLEEEW NFTKEITHYI RGGEAQAGKL
760 770 780 790 800
FCDIAGMLLK STGSFLEFGL QESCAEFWTS ADDSSASDEI RRSVIEISRA
810 820 830 840 850
LKELFHEARE RASKALGFAK MLRKDLEIAA EFRLSAPVRD LLDVLKSKQY
860 870 880 890 900
VKVQIPGLEN LQMFVPDTLA EEKSIILQLL NAAAGKDCSK DSDDVLIDAY
910 920 930 940 950
LLLTKHGDRA RDSEDSWGTW EAQPVKVVPQ VETVDTLRSM QVDNLLLVVM
960 970 980 990 1000
QSAHLTIQRK AFQQSIEGLM TLCQEQTSSQ PVIAKALQQL KNDALELCNR
1010 1020 1030 1040 1050
ISNAIDRVDH MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV
1060 1070 1080 1090 1100
VRLMSGEFRQ KIGDKYISFA RKWMNYVLTK CESGRGTRPR WATQGFDFLQ
1110 1120 1130 1140 1150
AIEPAFISAL PEDDFLSLQA LMNECIGHVI GKPHSPVTAI HRNSPRPMKV
1160 1170 1180 1190 1200
PRCHSDPPNP HLIIPTPEGF STRSMPSDAR SHGSPAAAAA AAAAAVAASR
1210 1220 1230 1240 1250
PSPSGGDSVL PKSISSAHDT RGSSVPENDR LASIAAELQF RSLSRHSSPT
1260 1270 1280 1290 1300
EERDEPAYPR GDSSGSTRRS WELRTLISQS KDTASKLGPI EAIQKSVRLF
1310 1320 1330 1340 1350
EEKRYREMRR KNIIGQVCDT PKSYDNVMHV GLRKVTFKWQ RGNKIGEGQY
1360 1370 1380 1390 1400
GKVYTCISVD TGELMAMKEI RFQPNDHKTI KETADELKIF EGIKHPNLVR
1410 1420 1430 1440 1450
YFGVELHREE MYIFMEYCDE GTLEEVSRLG LQEHVIRLYS KQITIAINVL
1460 1470 1480 1490 1500
HEHGIVHRDI KGANIFLTSS GLIKLGDFGC SVKLKNNAQT MPGEVNSTLG
1510 1520 1530 1540 1550
TAAYMAPEVI TRAKGEGHGR AADIWSLGCV VIEMVTGKRP WHEYEHNFQI
1560 1570 1580 1590 1600
MYKVGMGHKP PIPERLSPEG KDFLSHCLES DPKMRWTASQ LLDHSFVKVC

TDEE
Length:1,604
Mass (Da):181,238
Last modified:June 28, 2011 - v1
Checksum:i8E0307C6EBF24857
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109942 Genomic DNA. No translation available.
AL139393 Genomic DNA. No translation available.
AL591045 Genomic DNA. No translation available.
AL596452 Genomic DNA. No translation available.
KF458343 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000366920; ENSP00000355887; ENSG00000085511.
UCSCiuc063srw.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109942 Genomic DNA. No translation available.
AL139393 Genomic DNA. No translation available.
AL591045 Genomic DNA. No translation available.
AL596452 Genomic DNA. No translation available.
KF458343 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliF5H538.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000375986.

Proteomic databases

MaxQBiF5H538.
PaxDbiF5H538.
PRIDEiF5H538.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366920; ENSP00000355887; ENSG00000085511.
UCSCiuc063srw.1. human.

Organism-specific databases

HGNCiHGNC:6856. MAP3K4.
OpenTargetsiENSG00000085511.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4645. Eukaryota.
ENOG410XQZE. LUCA.
GeneTreeiENSGT00590000083157.

Enzyme and pathway databases

SignaLinkiF5H538.

Miscellaneous databases

ChiTaRSiMAP3K4. human.

Gene expression databases

BgeeiENSG00000085511.
ExpressionAtlasiF5H538. baseline and differential.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF5H538_HUMAN
AccessioniPrimary (citable) accession number: F5H538
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 30, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.