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F5H538

- F5H538_HUMAN

UniProt

F5H538 - F5H538_HUMAN

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Protein
Submitted name: Mitogen-activated protein kinase kinase kinase 4
Gene
MAP3K4
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiF5H538.

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 4Imported
Gene namesi
Name:MAP3K4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:6856. MAP3K4.

Expressioni

Gene expression databases

ArrayExpressiF5H538.
BgeeiF5H538.

Structurei

3D structure databases

ProteinModelPortaliF5H538.

Family & Domainsi

Phylogenomic databases

KOiK04428.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H538-1 [UniParc]FASTAAdd to Basket

« Hide

MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA     50
RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ 100
RNNVGRPASR SNLKEKMNAP NQPPHKDTGK TVENVEEYSY KQEKKIRAAL 150
RTTERDRKKN VQCSFMLDSV GGSLPKKSIP DVDLNKPYLS LGCSNAKLPV 200
SVPMPIARPA RQTSRTDCPA DRLKFFETLR LLLKLTSVSK KKDREQRGQE 250
NTSGFWLNRS NELIWLELQA WHAGRTINDQ DFFLYTARQA IPDIINEILT 300
FKVDYGSFAF VRDRAGFNGT SVEGQCKATP GTKIVGYSTH HEHLQRQRVS 350
FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT 400
KDLNQKLRIM GTVLGIKNLS DIGWPVFEIP SPRPSKGNEP EYEGDDTEGE 450
LKELESSTDE SEEEQISDPR VPEIRQPIDN SFDIQSRDCI SKKLERLESE 500
DDSLGWGAPD WSTEAGFSRH CLTSIYRPFV DKALKQMGLR KLILRLHKLM 550
DGSLQRARIA LVKNDRPVEF SEFPDPMWGS DYVQLSRTPP SSEEKCSAVS 600
WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ 650
LVRECKEVLK GGLLMKQYYQ FMLQEVLEDL EKPDCNIDAF EEDLHKMLMV 700
YFDYMRSWIQ MLQQLPQASH SLKNLLEEEW NFTKEITHYI RGGEAQAGKL 750
FCDIAGMLLK STGSFLEFGL QESCAEFWTS ADDSSASDEI RRSVIEISRA 800
LKELFHEARE RASKALGFAK MLRKDLEIAA EFRLSAPVRD LLDVLKSKQY 850
VKVQIPGLEN LQMFVPDTLA EEKSIILQLL NAAAGKDCSK DSDDVLIDAY 900
LLLTKHGDRA RDSEDSWGTW EAQPVKVVPQ VETVDTLRSM QVDNLLLVVM 950
QSAHLTIQRK AFQQSIEGLM TLCQEQTSSQ PVIAKALQQL KNDALELCNR 1000
ISNAIDRVDH MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV 1050
VRLMSGEFRQ KIGDKYISFA RKWMNYVLTK CESGRGTRPR WATQGFDFLQ 1100
AIEPAFISAL PEDDFLSLQA LMNECIGHVI GKPHSPVTAI HRNSPRPMKV 1150
PRCHSDPPNP HLIIPTPEGF STRSMPSDAR SHGSPAAAAA AAAAAVAASR 1200
PSPSGGDSVL PKSISSAHDT RGSSVPENDR LASIAAELQF RSLSRHSSPT 1250
EERDEPAYPR GDSSGSTRRS WELRTLISQS KDTASKLGPI EAIQKSVRLF 1300
EEKRYREMRR KNIIGQVCDT PKSYDNVMHV GLRKVTFKWQ RGNKIGEGQY 1350
GKVYTCISVD TGELMAMKEI RFQPNDHKTI KETADELKIF EGIKHPNLVR 1400
YFGVELHREE MYIFMEYCDE GTLEEVSRLG LQEHVIRLYS KQITIAINVL 1450
HEHGIVHRDI KGANIFLTSS GLIKLGDFGC SVKLKNNAQT MPGEVNSTLG 1500
TAAYMAPEVI TRAKGEGHGR AADIWSLGCV VIEMVTGKRP WHEYEHNFQI 1550
MYKVGMGHKP PIPERLSPEG KDFLSHCLES DPKMRWTASQ LLDHSFVKVC 1600
TDEE 1604
Length:1,604
Mass (Da):181,238
Last modified:June 28, 2011 - v1
Checksum:i8E0307C6EBF24857
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL109942 Genomic DNA. No translation available.
AL139393 Genomic DNA. No translation available.
AL591045 Genomic DNA. No translation available.
AL596452 Genomic DNA. No translation available.
RefSeqiXP_005267045.1. XM_005266988.1.
UniGeneiHs.390428.

Genome annotation databases

EnsembliENST00000366920; ENSP00000355887; ENSG00000085511.
GeneIDi4216.
KEGGihsa:4216.
UCSCiuc010kkc.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL109942 Genomic DNA. No translation available.
AL139393 Genomic DNA. No translation available.
AL591045 Genomic DNA. No translation available.
AL596452 Genomic DNA. No translation available.
RefSeqi XP_005267045.1. XM_005266988.1.
UniGenei Hs.390428.

3D structure databases

ProteinModelPortali F5H538.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366920 ; ENSP00000355887 ; ENSG00000085511 .
GeneIDi 4216.
KEGGi hsa:4216.
UCSCi uc010kkc.2. human.

Organism-specific databases

CTDi 4216.
HGNCi HGNC:6856. MAP3K4.
GenAtlasi Search...

Phylogenomic databases

KOi K04428.

Enzyme and pathway databases

SignaLinki F5H538.

Miscellaneous databases

ChiTaRSi MAP3K4. human.
GenomeRNAii 4216.
NextBioi 35508916.

Gene expression databases

ArrayExpressi F5H538.
Bgeei F5H538.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H538_HUMAN
AccessioniPrimary (citable) accession number: F5H538
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 11, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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