Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Mitogen-activated protein kinase kinase kinase 4

Gene

MAP3K4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

SignaLinkiF5H538

Names & Taxonomyi

Protein namesi
Submitted name:
Mitogen-activated protein kinase kinase kinase 4Imported
Gene namesi
Name:MAP3K4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000085511.19
HGNCiHGNC:6856 MAP3K4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000085511

PTM / Processingi

Proteomic databases

EPDiF5H538
MaxQBiF5H538
PRIDEiF5H538

Expressioni

Gene expression databases

BgeeiENSG00000085511
ExpressionAtlasiF5H538 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H538
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1339 – 1597Protein kinaseInterPro annotationAdd BLAST259

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili444 – 464Sequence analysisAdd BLAST21
Coiled coili987 – 1007Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4645 Eukaryota
ENOG410XQZE LUCA
GeneTreeiENSGT00880000138034

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

F5H538-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA
60 70 80 90 100
RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ
110 120 130 140 150
RNNVGRPASR SNLKEKMNAP NQPPHKDTGK TVENVEEYSY KQEKKIRAAL
160 170 180 190 200
RTTERDRKKN VQCSFMLDSV GGSLPKKSIP DVDLNKPYLS LGCSNAKLPV
210 220 230 240 250
SVPMPIARPA RQTSRTDCPA DRLKFFETLR LLLKLTSVSK KKDREQRGQE
260 270 280 290 300
NTSGFWLNRS NELIWLELQA WHAGRTINDQ DFFLYTARQA IPDIINEILT
310 320 330 340 350
FKVDYGSFAF VRDRAGFNGT SVEGQCKATP GTKIVGYSTH HEHLQRQRVS
360 370 380 390 400
FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT
410 420 430 440 450
KDLNQKLRIM GTVLGIKNLS DIGWPVFEIP SPRPSKGNEP EYEGDDTEGE
460 470 480 490 500
LKELESSTDE SEEEQISDPR VPEIRQPIDN SFDIQSRDCI SKKLERLESE
510 520 530 540 550
DDSLGWGAPD WSTEAGFSRH CLTSIYRPFV DKALKQMGLR KLILRLHKLM
560 570 580 590 600
DGSLQRARIA LVKNDRPVEF SEFPDPMWGS DYVQLSRTPP SSEEKCSAVS
610 620 630 640 650
WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ
660 670 680 690 700
LVRECKEVLK GGLLMKQYYQ FMLQEVLEDL EKPDCNIDAF EEDLHKMLMV
710 720 730 740 750
YFDYMRSWIQ MLQQLPQASH SLKNLLEEEW NFTKEITHYI RGGEAQAGKL
760 770 780 790 800
FCDIAGMLLK STGSFLEFGL QESCAEFWTS ADDSSASDEI RRSVIEISRA
810 820 830 840 850
LKELFHEARE RASKALGFAK MLRKDLEIAA EFRLSAPVRD LLDVLKSKQY
860 870 880 890 900
VKVQIPGLEN LQMFVPDTLA EEKSIILQLL NAAAGKDCSK DSDDVLIDAY
910 920 930 940 950
LLLTKHGDRA RDSEDSWGTW EAQPVKVVPQ VETVDTLRSM QVDNLLLVVM
960 970 980 990 1000
QSAHLTIQRK AFQQSIEGLM TLCQEQTSSQ PVIAKALQQL KNDALELCNR
1010 1020 1030 1040 1050
ISNAIDRVDH MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV
1060 1070 1080 1090 1100
VRLMSGEFRQ KIGDKYISFA RKWMNYVLTK CESGRGTRPR WATQGFDFLQ
1110 1120 1130 1140 1150
AIEPAFISAL PEDDFLSLQA LMNECIGHVI GKPHSPVTAI HRNSPRPMKV
1160 1170 1180 1190 1200
PRCHSDPPNP HLIIPTPEGF STRSMPSDAR SHGSPAAAAA AAAAAVAASR
1210 1220 1230 1240 1250
PSPSGGDSVL PKSISSAHDT RGSSVPENDR LASIAAELQF RSLSRHSSPT
1260 1270 1280 1290 1300
EERDEPAYPR GDSSGSTRRS WELRTLISQS KDTASKLGPI EAIQKSVRLF
1310 1320 1330 1340 1350
EEKRYREMRR KNIIGQVCDT PKSYDNVMHV GLRKVTFKWQ RGNKIGEGQY
1360 1370 1380 1390 1400
GKVYTCISVD TGELMAMKEI RFQPNDHKTI KETADELKIF EGIKHPNLVR
1410 1420 1430 1440 1450
YFGVELHREE MYIFMEYCDE GTLEEVSRLG LQEHVIRLYS KQITIAINVL
1460 1470 1480 1490 1500
HEHGIVHRDI KGANIFLTSS GLIKLGDFGC SVKLKNNAQT MPGEVNSTLG
1510 1520 1530 1540 1550
TAAYMAPEVI TRAKGEGHGR AADIWSLGCV VIEMVTGKRP WHEYEHNFQI
1560 1570 1580 1590 1600
MYKVGMGHKP PIPERLSPEG KDFLSHCLES DPKMRWTASQ LLDHSFVKVC

TDEE
Length:1,604
Mass (Da):181,238
Last modified:June 28, 2011 - v1
Checksum:i8E0307C6EBF24857
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109942 Genomic DNA No translation available.
AL139393 Genomic DNA No translation available.
AL591045 Genomic DNA No translation available.
AL596452 Genomic DNA No translation available.
KF458343 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000366920; ENSP00000355887; ENSG00000085511
UCSCiuc063srw.1 human

Similar proteinsi

Entry informationi

Entry nameiF5H538_HUMAN
AccessioniPrimary (citable) accession number: F5H538
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: June 20, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health