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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

CACNA1C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACNA1CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1390. CACNA1C.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei128 – 145HelicalSequence analysisAdd BLAST18
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei197 – 215HelicalSequence analysisAdd BLAST19
Transmembranei268 – 290HelicalSequence analysisAdd BLAST23
Transmembranei349 – 370HelicalSequence analysisAdd BLAST22
Transmembranei382 – 404HelicalSequence analysisAdd BLAST23
Transmembranei550 – 568HelicalSequence analysisAdd BLAST19
Transmembranei676 – 698HelicalSequence analysisAdd BLAST23
Transmembranei752 – 778HelicalSequence analysisAdd BLAST27
Transmembranei926 – 945HelicalSequence analysisAdd BLAST20
Transmembranei957 – 979HelicalSequence analysisAdd BLAST23
Transmembranei999 – 1022HelicalSequence analysisAdd BLAST24
Transmembranei1043 – 1076HelicalSequence analysisAdd BLAST34
Transmembranei1168 – 1194HelicalSequence analysisAdd BLAST27
Transmembranei1245 – 1266HelicalSequence analysisAdd BLAST22
Transmembranei1278 – 1298HelicalSequence analysisAdd BLAST21
Transmembranei1384 – 1402HelicalSequence analysisAdd BLAST19
Transmembranei1478 – 1501HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151067.

PTM / Processingi

Proteomic databases

PaxDbiF5H522.
PRIDEiF5H522.

Expressioni

Gene expression databases

BgeeiENSG00000151067.
ExpressionAtlasiF5H522. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266376.

Structurei

3D structure databases

ProteinModelPortaliF5H522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1635 – 1669Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili781 – 807Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR031688. CAC1F_C.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 2 hits.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNRGTPAGM LDQKKGKFAW FSHSTETHVS MPTSETESVN
510 520 530 540 550
TENVAGGDIE GENCGARLAH RISKSKFSRY WRRWNRFCRR KCRAAVKSNV
560 570 580 590 600
FYWLVIFLVF LNTLTIASEH YNQPNWLTEV QDTANKALLA LFTAEMLLKM
610 620 630 640 650
YSLGLQAYFV SLFNRFDCFV VCGGILETIL VETKIMSPLG ISVLRCVRLL
660 670 680 690 700
RIFKITRYWN SLSNLVASLL NSVRSIASLL LLLFLFIIIF SLLGMQLFGG
710 720 730 740 750
KFNFDEMQTR RSTFDNFPQS LLTVFQILTG EDWNSVMYDG IMAYGGPSFP
760 770 780 790 800
GMLVCIYFII LFICGNYILL NVFLAIAVDN LADAESLTSA QKEEEEEKER
810 820 830 840 850
KKLARTASPE KKQELVEKPA VGESKEEKIE LKSITADGES PPATKINMDD
860 870 880 890 900
LQPNENEDKS PYPNPETTGE EDEEEPEMPV GPRPRPLSEL HLKEKAVPMP
910 920 930 940 950
EASAFFIFSS NNRFRLQCHR IVNDTIFTNL ILFFILLSSI SLAAEDPVQH
960 970 980 990 1000
TSFRNHILFY FDIVFTTIFT IEIALKMTAY GAFLHKGSFC RNYFNILDLL
1010 1020 1030 1040 1050
VVSVSLISFG IQSSAINVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA
1060 1070 1080 1090 1100
IRTIGNIVIV TTLLQFMFAC IGVQLFKGKL YTCSDSSKQT EAECKGNYIT
1110 1120 1130 1140 1150
YKDGEVDHPI IQPRSWENSK FDFDNVLAAM MALFTVSTFE GWPELLYRSI
1160 1170 1180 1190 1200
DSHTEDKGPI YNYRVEISIF FIIYIIIIAF FMMNIFVGFV IVTFQEQGEQ
1210 1220 1230 1240 1250
EYKNCELDKN QRQCVEYALK ARPLRRYIPK NQHQYKVWYV VNSTYFEYLM
1260 1270 1280 1290 1300
FVLILLNTIC LAMQHYGQSC LFKIAMNILN MLFTGLFTVE MILKLIAFKP
1310 1320 1330 1340 1350
KHYFCDAWNT FDALIVVGSI VDIAITEVNP AEHTQCSPSM NAEENSRISI
1360 1370 1380 1390 1400
TFFRLFRVMR LVKLLSRGEG IRTLLWTFIK SFQALPYVAL LIVMLFFIYA
1410 1420 1430 1440 1450
VIGMQVFGKI ALNDTTEINR NNNFQTFPQA VLLLFRCATG EAWQDIMLAC
1460 1470 1480 1490 1500
MPGKKCAPES EPSNSTEGET PCGSSFAVFY FISFYMLCAF LIINLFVAVI
1510 1520 1530 1540 1550
MDNFDYLTRD WSILGPHHLD EFKRIWAEYD PEAKGRIKHL DVVTLLRRIQ
1560 1570 1580 1590 1600
PPLGFGKLCP HRVACKRLVS MNMPLNSDGT VMFNATLFAL VRTALRIKTE
1610 1620 1630 1640 1650
GNLEQANEEL RAIIKKIWKR TSMKLLDQVV PPAGDDEVTV GKFYATFLIQ
1660 1670 1680 1690 1700
EYFRKFKKRK EQGLVGKPSQ RNALSLQAGL RTLHDIGPEI RRAISGDLTA
1710 1720 1730 1740 1750
EEELDKAMKE AVSAASEDDI FRRAGGLFGN HVSYYQSDGR SAFPQTFTTQ
1760 1770 1780 1790 1800
RPLHINKAGS SQGDTESPSH EKLVDSTFTP SSYSSTGSNA NINNANNTAL
1810 1820 1830 1840 1850
GRLPRPAGYP STVSTVEGHG PPLSPAIRVQ EVAWKLSSNR CHSRESQAAM
1860 1870 1880 1890 1900
AGQEETSQDE TYEVKMNHDT EACSEPSLLS TEMLSYQDDE NRQLTLPEED
1910 1920 1930 1940 1950
KRDIRQSPKR GFLRSASLGR RASFHLECLK RQKDRGGDIS QKTVLPLHLV
1960 1970 1980 1990 2000
HHQALAVAGL SPLLQRSHSP ASFPRPFATP PATPGSRGWP PQPVPTLRLE
2010 2020 2030 2040 2050
GVESSEKLNS SFPSIHCGSW AETTPGGGGS SAARRVRPVS LMVPSQAGAP
2060 2070 2080 2090 2100
GRQFHGSASS LVEAVLISEG LGQFAQDPKF IEVTTQELAD ACDMTIEEME
2110 2120 2130 2140 2150
SAADNILSGG APQSPNGALL PFVNCRDAGQ DRAGGEEDAG CVRARGRPSE
2160
EELQDSRVYV SSL
Length:2,163
Mass (Da):242,406
Last modified:June 28, 2011 - v1
Checksum:iD56176EEDFCAA0CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005293 Genomic DNA. No translation available.
AC005342 Genomic DNA. No translation available.
AC005344 Genomic DNA. No translation available.
AC005414 Genomic DNA. No translation available.
AC005866 Genomic DNA. No translation available.
AC006051 Genomic DNA. No translation available.
KF455573 Genomic DNA. No translation available.
KF455574 Genomic DNA. No translation available.
RefSeqiXP_011519325.1. XM_011521023.2.
UniGeneiHs.118262.
Hs.690010.

Genome annotation databases

EnsembliENST00000335762; ENSP00000336982; ENSG00000151067.
GeneIDi775.
UCSCiuc001qkv.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005293 Genomic DNA. No translation available.
AC005342 Genomic DNA. No translation available.
AC005344 Genomic DNA. No translation available.
AC005414 Genomic DNA. No translation available.
AC005866 Genomic DNA. No translation available.
AC006051 Genomic DNA. No translation available.
KF455573 Genomic DNA. No translation available.
KF455574 Genomic DNA. No translation available.
RefSeqiXP_011519325.1. XM_011521023.2.
UniGeneiHs.118262.
Hs.690010.

3D structure databases

ProteinModelPortaliF5H522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000266376.

Proteomic databases

PaxDbiF5H522.
PRIDEiF5H522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335762; ENSP00000336982; ENSG00000151067.
GeneIDi775.
UCSCiuc001qkv.2. human.

Organism-specific databases

CTDi775.
HGNCiHGNC:1390. CACNA1C.
OpenTargetsiENSG00000151067.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.

Miscellaneous databases

ChiTaRSiCACNA1C. human.
GenomeRNAii775.

Gene expression databases

BgeeiENSG00000151067.
ExpressionAtlasiF5H522. baseline and differential.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR031688. CAC1F_C.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 2 hits.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF5H522_HUMAN
AccessioniPrimary (citable) accession number: F5H522
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.