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Protein

Tyrosine-protein phosphatase

Gene

PTPN6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation

Enzyme and pathway databases

SignaLinkiF5H4Z1.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:PTPN6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111679.16.
HGNCiHGNC:9658. PTPN6.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111679.

PTM / Processingi

Proteomic databases

MaxQBiF5H4Z1.
PaxDbiF5H4Z1.
PeptideAtlasiF5H4Z1.
PRIDEiF5H4Z1.

Expressioni

Gene expression databases

BgeeiENSG00000111679.
ExpressionAtlasiF5H4Z1. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H4Z1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 58SH2InterPro annotationAdd BLAST53

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00900000140780.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR000980. SH2.
IPR036860. SH2_dom_sf.
PfamiView protein in Pfam
PF00017. SH2. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiView protein in PROSITE
PS50001. SH2. 1 hit.

Sequencei

Sequence statusi: Complete.

F5H4Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRGWFHRD LSGLDAETLL KGRGVHGSFL ARPSRKNQGD FSLSVRTATA

PSSTSSTR
Length:58
Mass (Da):6,305
Last modified:June 28, 2011 - v1
Checksum:iF8B09DD378135612
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000542848; ENSP00000444805; ENSG00000111679.
UCSCiuc058kod.1. human.

Similar proteinsi

Entry informationi

Entry nameiF5H4Z1_HUMAN
AccessioniPrimary (citable) accession number: F5H4Z1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 25, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported