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Submitted name:

Tumor necrosis factor receptor superfamily member 1A



Homo sapiens (Human)
Unreviewed - Annotation score: 4 out of 5- Protein predictedi


GO - Molecular functioni

  1. tumor necrosis factor-activated receptor activity Source: Ensembl

GO - Biological processi

  1. cellular response to estradiol stimulus Source: Ensembl
  2. defense response to bacterium Source: Ensembl
  3. inflammatory response Source: Ensembl
  4. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  5. negative regulation of apoptotic process Source: Ensembl
  6. negative regulation of gene expression Source: Ensembl
  7. negative regulation of interleukin-6 production Source: Ensembl
  8. positive regulation of angiogenesis Source: Ensembl
  9. positive regulation of inflammatory response Source: Ensembl
  10. positive regulation of neuron apoptotic process Source: Ensembl
  11. positive regulation of protein import into nucleus, translocation Source: Ensembl
  12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  13. positive regulation of tumor necrosis factor production Source: Ensembl
  14. protein heterooligomerization Source: Ensembl
  15. response to alkaloid Source: Ensembl
  16. response to amino acid Source: Ensembl
  17. response to ethanol Source: Ensembl
  18. response to hypoxia Source: Ensembl
  19. response to lipopolysaccharide Source: Ensembl
  20. response to wounding Source: Ensembl
  21. tetrapyrrole metabolic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily member 1AImported
Gene namesi
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases


Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cell surface Source: Ensembl
  3. cytosol Source: Ensembl
  4. extracellular space Source: Ensembl
  5. membrane raft Source: Ensembl
  6. mitochondrion Source: Ensembl
  7. nucleus Source: Ensembl
  8. protein complex Source: Ensembl
  9. synapse Source: Ensembl
Complete GO annotation...


Gene expression databases

ExpressionAtlasiF5H4T5. baseline and differential.



3D structure databases

SMRiF5H4T5. Positions 41-71.

Family & Domainsi

Phylogenomic databases


Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]


Sequence statusi: Complete.

F5H4T5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
60 70
Mass (Da):7,807
Last modified:June 28, 2011 - v1

Sequence databases

Select the link destinations:
Links Updated
AC006057 Genomic DNA. No translation available.
KF455591 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000543048; ENSP00000439981; ENSG00000067182.


Sequence databases

Select the link destinations:
Links Updated
AC006057 Genomic DNA. No translation available.
KF455591 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F5H4T5.
SMRi F5H4T5. Positions 41-71.
ModBasei Search...
MobiDBi Search...


BindingDBi F5H4T5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000543048 ; ENSP00000439981 ; ENSG00000067182 .

Organism-specific databases

GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000064001.

Miscellaneous databases

ChiTaRSi TNFRSF1A. human.
NextBioi 35508857.

Gene expression databases

Bgeei F5H4T5.
ExpressionAtlasi F5H4T5. baseline and differential.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view ]
Pfami PF00020. TNFR_c6. 1 hit.
[Graphical view ]
ProtoNeti Search...


« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H4T5_HUMAN
AccessioniPrimary (citable) accession number: F5H4T5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: January 7, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.



The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.