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Protein
Submitted name:

Nuclear factor of-activated T-cells, cytoplasmic 1

Gene

NFATC1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear factor of-activated T-cells, cytoplasmic 1Imported
Gene namesi
Name:NFATC1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:7775. NFATC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiF5H4S8.
PeptideAtlasiF5H4S8.

Expressioni

Gene expression databases

BgeeiF5H4S8.
ExpressionAtlasiF5H4S8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327850.

Structurei

3D structure databases

ProteinModelPortaliF5H4S8.
SMRiF5H4S8. Positions 1-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 120120RHD (Rel-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RHD (Rel-like) domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IHFR. Eukaryota.
ENOG41105U2. LUCA.
GeneTreeiENSGT00550000074562.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR015647. NFAT1.
IPR008967. p53-like_TF_DNA-bd.
IPR032397. RHD_dimer.
IPR011539. RHD_DNA_bind_dom.
[Graphical view]
PANTHERiPTHR12533. PTHR12533. 1 hit.
PTHR12533:SF5. PTHR12533:SF5. 1 hit.
PfamiPF16179. RHD_dimer. 1 hit.
PF00554. RHD_DNA_bind. 1 hit.
[Graphical view]
PRINTSiPR01789. NUCFACTORATC.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50254. REL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H4S8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQLFIGTAD DRLLRPHAFY QVHRITGKTV STTSHEAILS NTKVLEIPLL
60 70 80 90 100
PENSMRAVID CAGILKLRNS DIELRKGETD IGRKNTRVRL VFRVHVPQPS
110 120 130 140 150
GRTLSLQVAS NPIECSQRSA QELPLVEKQS TDSYPVVGGK KMVLSGHNFL
160 170 180 190 200
QDSKVIFVEK APDGHHVWEM EAKTDRDLCK PNSLVVEIPP FRNQRITSPV
210 220 230 240 250
HVSFYVCNGK RKRSQYQRFT YLPANVPIIK TEPTDDYEPA PTCGPVSQGL
260 270 280 290 300
SPLPRPYYSQ QLAMPPDPSS CLVAGFPPCP QRSTLMPAAP GVSPKLHDLS
310 320 330 340 350
PAAYTKGVAS PGHCHLGLPQ PAGEAPAVQD VPRPVATHPG SPGQPPPALL
360 370 380 390 400
PQQVSAPPSS SCPPGLEHSL CPSSPSPPLP PATQEPTCLQ PCSPACPPAT
410 420 430 440 450
GRPQHLPSTV RRDESPTAGP RLLPEVHEDG SPNLAPIPVT VKREPEELDQ
460 470
LYLDDVNEII RNDLSSTSTH S
Length:471
Mass (Da):51,106
Last modified:June 28, 2011 - v1
Checksum:i48519BBBB121A50C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018445 Genomic DNA. No translation available.
AC023090 Genomic DNA. No translation available.
RefSeqiNP_001265602.1. NM_001278673.1.
UniGeneiHs.534074.
Hs.701518.

Genome annotation databases

EnsembliENST00000545796; ENSP00000439992; ENSG00000131196.
GeneIDi4772.
UCSCiuc010xfj.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018445 Genomic DNA. No translation available.
AC023090 Genomic DNA. No translation available.
RefSeqiNP_001265602.1. NM_001278673.1.
UniGeneiHs.534074.
Hs.701518.

3D structure databases

ProteinModelPortaliF5H4S8.
SMRiF5H4S8. Positions 1-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327850.

Proteomic databases

PaxDbiF5H4S8.
PeptideAtlasiF5H4S8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000545796; ENSP00000439992; ENSG00000131196.
GeneIDi4772.
UCSCiuc010xfj.3. human.

Organism-specific databases

CTDi4772.
HGNCiHGNC:7775. NFATC1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHFR. Eukaryota.
ENOG41105U2. LUCA.
GeneTreeiENSGT00550000074562.

Miscellaneous databases

ChiTaRSiNFATC1. human.
GenomeRNAii4772.

Gene expression databases

BgeeiF5H4S8.
ExpressionAtlasiF5H4S8. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.340. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR008366. NFAT.
IPR015647. NFAT1.
IPR008967. p53-like_TF_DNA-bd.
IPR032397. RHD_dimer.
IPR011539. RHD_DNA_bind_dom.
[Graphical view]
PANTHERiPTHR12533. PTHR12533. 1 hit.
PTHR12533:SF5. PTHR12533:SF5. 1 hit.
PfamiPF16179. RHD_dimer. 1 hit.
PF00554. RHD_DNA_bind. 1 hit.
[Graphical view]
PRINTSiPR01789. NUCFACTORATC.
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50254. REL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF5H4S8_HUMAN
AccessioniPrimary (citable) accession number: F5H4S8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 6, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.