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F5H2Z2

- F5H2Z2_HUMAN

UniProt

F5H2Z2 - F5H2Z2_HUMAN

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Protein
Submitted name:

Alpha-2-macroglobulin-like protein 1

Gene

A2ML1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. endopeptidase inhibitor activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-2-macroglobulin-like protein 1Imported
Gene namesi
Name:A2ML1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:23336. A2ML1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF5H2Z2.

Expressioni

Gene expression databases

BgeeiF5H2Z2.
ExpressionAtlasiF5H2Z2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H2Z2.
SMRiF5H2Z2. Positions 28-961.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118982.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H2Z2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLIGKGSLVM EGQKHLNSKK KGLKASFSLS LTFTSRLAPD PSLVIYAIFP
60 70 80 90 100
SGGVVADKIQ FSVEMCFDNQ VSLGFSPSQQ LPGAEVELQL QAAPGSLCAL
110 120 130 140 150
RAVDESVLLL RPDRELSNRS VYGMFPFWYG HYPYQVAEYD QCPVSGPWDF
160 170 180 190 200
PQPLIDPMPQ GHSSQRSIIW RPSFSEGTDL FSFFRDVGLK ILSNAKIKKP
210 220 230 240 250
VDCSHRSPEY STAMGAGGGH PEAFESSTPL HQAEDSQVRQ YFPETWLWDL
260 270 280 290 300
FPIGNSGKEA VHVTVPDAIT EWKAMSFCTS QSRGFGLSPT VGLTAFKPFF
310 320 330 340 350
VDLTLPYSVV RGESFRLTAT IFNYLKDCIR VQTDLAKSHE YQLESWADSQ
360 370 380 390 400
TSSCLCADDA KTHHWNITAV KLGHINFTIS TKILDSNEPC GGQKGFVPQK
410 420 430 440 450
GRSDTLIKPV LVKPEGVLVE KTHSSLLCPK GKVASESVSL ELPVDIVPDS
460 470 480 490 500
TKAYVTVLGD IMGTALQNLD GLVQMPSGCG EQNMVLFAPI IYVLQYLEKA
510 520 530 540 550
GLLTEEIRSR AVGFLEIGYQ KELMYKHSNG SYSAFGERDG NGNTWLTAFV
560 570 580 590 600
TKCFGQAQKF IFIDPKNIQD ALKWMAGNQL PSGCYANVGN LLHTAMKGGV
610 620 630 640 650
DDEVSLTAYV TAALLEMGKD VDDPMVSQGL RCLKNSATST TNLYTQALLA
660 670 680 690 700
YIFSLAGEMD IRNILLKQLD QQAIISGESI YWSQKPTPSS NASPWSEPAA
710 720 730 740 750
VDVELTAYAL LAQLTKPSLT QKEIAKATSI VAWLAKQHNA YGGFSSTQDT
760 770 780 790 800
VVALQALAKY ATTAYMPSEE INLVVKSTEN FQRTFNIQSV NRLVFQQDTL
810 820 830 840 850
PNVPGMYTLE ASGQGCVYVQ TVLRYNILPP TNMKTFSLSV EIGKARCEQP
860 870 880 890 900
TSPRSLTLTI HTSYVGSRSS SNMAIVEVKM LSGFSPMEGT NQLLLQQPLV
910 920 930 940 950
KKVEFGTDTL NIYLDELIKN TQTYTFTISQ SVLVTNLKPA TIKVYDYYLP
960
DEQATIQYSD PCE
Length:963
Mass (Da):105,968
Last modified:June 28, 2011 - v1
Checksum:iF768614879F8E89C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006513 Genomic DNA. No translation available.
AC006581 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000539547; ENSP00000438292; ENSG00000166535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006513 Genomic DNA. No translation available.
AC006581 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F5H2Z2.
SMRi F5H2Z2. Positions 28-961.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F5H2Z2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000539547 ; ENSP00000438292 ; ENSG00000166535 .

Organism-specific databases

HGNCi HGNC:23336. A2ML1.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000118982.

Miscellaneous databases

ChiTaRSi A2ML1. human.
NextBioi 35508516.

Gene expression databases

Bgeei F5H2Z2.
ExpressionAtlasi F5H2Z2. baseline and differential.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProi IPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H2Z2_HUMAN
AccessioniPrimary (citable) accession number: F5H2Z2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3