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F5H2Z2

- F5H2Z2_HUMAN

UniProt

F5H2Z2 - F5H2Z2_HUMAN

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Protein
Submitted name:

Alpha-2-macroglobulin-like protein 1

Gene
A2ML1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. endopeptidase inhibitor activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-2-macroglobulin-like protein 1Imported
Gene namesi
Name:A2ML1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:23336. A2ML1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiF5H2Z2.

Expressioni

Gene expression databases

ArrayExpressiF5H2Z2.
BgeeiF5H2Z2.

Structurei

3D structure databases

ProteinModelPortaliF5H2Z2.
SMRiF5H2Z2. Positions 28-961.

Family & Domainsi

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProiIPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F5H2Z2-1 [UniParc]FASTAAdd to Basket

« Hide

MLIGKGSLVM EGQKHLNSKK KGLKASFSLS LTFTSRLAPD PSLVIYAIFP    50
SGGVVADKIQ FSVEMCFDNQ VSLGFSPSQQ LPGAEVELQL QAAPGSLCAL 100
RAVDESVLLL RPDRELSNRS VYGMFPFWYG HYPYQVAEYD QCPVSGPWDF 150
PQPLIDPMPQ GHSSQRSIIW RPSFSEGTDL FSFFRDVGLK ILSNAKIKKP 200
VDCSHRSPEY STAMGAGGGH PEAFESSTPL HQAEDSQVRQ YFPETWLWDL 250
FPIGNSGKEA VHVTVPDAIT EWKAMSFCTS QSRGFGLSPT VGLTAFKPFF 300
VDLTLPYSVV RGESFRLTAT IFNYLKDCIR VQTDLAKSHE YQLESWADSQ 350
TSSCLCADDA KTHHWNITAV KLGHINFTIS TKILDSNEPC GGQKGFVPQK 400
GRSDTLIKPV LVKPEGVLVE KTHSSLLCPK GKVASESVSL ELPVDIVPDS 450
TKAYVTVLGD IMGTALQNLD GLVQMPSGCG EQNMVLFAPI IYVLQYLEKA 500
GLLTEEIRSR AVGFLEIGYQ KELMYKHSNG SYSAFGERDG NGNTWLTAFV 550
TKCFGQAQKF IFIDPKNIQD ALKWMAGNQL PSGCYANVGN LLHTAMKGGV 600
DDEVSLTAYV TAALLEMGKD VDDPMVSQGL RCLKNSATST TNLYTQALLA 650
YIFSLAGEMD IRNILLKQLD QQAIISGESI YWSQKPTPSS NASPWSEPAA 700
VDVELTAYAL LAQLTKPSLT QKEIAKATSI VAWLAKQHNA YGGFSSTQDT 750
VVALQALAKY ATTAYMPSEE INLVVKSTEN FQRTFNIQSV NRLVFQQDTL 800
PNVPGMYTLE ASGQGCVYVQ TVLRYNILPP TNMKTFSLSV EIGKARCEQP 850
TSPRSLTLTI HTSYVGSRSS SNMAIVEVKM LSGFSPMEGT NQLLLQQPLV 900
KKVEFGTDTL NIYLDELIKN TQTYTFTISQ SVLVTNLKPA TIKVYDYYLP 950
DEQATIQYSD PCE 963
Length:963
Mass (Da):105,968
Last modified:June 28, 2011 - v1
Checksum:iF768614879F8E89C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006513 Genomic DNA. No translation available.
AC006581 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000539547; ENSP00000438292; ENSG00000166535.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006513 Genomic DNA. No translation available.
AC006581 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F5H2Z2.
SMRi F5H2Z2. Positions 28-961.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi F5H2Z2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000539547 ; ENSP00000438292 ; ENSG00000166535 .

Organism-specific databases

HGNCi HGNC:23336. A2ML1.
GenAtlasi Search...

Miscellaneous databases

ChiTaRSi A2ML1. human.
NextBioi 35508516.

Gene expression databases

ArrayExpressi F5H2Z2.
Bgeei F5H2Z2.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
2.60.40.690. 1 hit.
InterProi IPR009048. A-macroglobulin_rcpt-bd.
IPR011626. A2M_comp.
IPR011625. A2M_N_2.
IPR014756. Ig_E-set.
IPR001599. Macroglobln_a2.
IPR019742. MacrogloblnA2_CS.
IPR019565. MacrogloblnA2_thiol-ester-bond.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00207. A2M. 1 hit.
PF07678. A2M_comp. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF07677. A2M_recep. 1 hit.
PF10569. Thiol-ester_cl. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
SSF49410. SSF49410. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00477. ALPHA_2_MACROGLOBULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiF5H2Z2_HUMAN
AccessioniPrimary (citable) accession number: F5H2Z2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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