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Protein
Submitted name:

C-1-tetrahydrofolate synthase, cytoplasmic

Gene

MTHFD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
C-1-tetrahydrofolate synthase, cytoplasmicImported
Gene namesi
Name:MTHFD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100714.15
HGNCiHGNC:7432 MTHFD1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100714

PTM / Processingi

Proteomic databases

EPDiF5H2F4
MaxQBiF5H2F4
PeptideAtlasiF5H2F4
PRIDEiF5H2F4

Expressioni

Gene expression databases

BgeeiENSG00000100714
ExpressionAtlasiF5H2F4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H2F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 181THF_DHG_CYHInterPro annotationAdd BLAST120
Domaini185 – 349THF_DHG_CYH_CInterPro annotationAdd BLAST165

Phylogenomic databases

eggNOGiKOG4230 Eukaryota
COG0190 LUCA
COG2759 LUCA
GeneTreeiENSGT00900000140894
OMAiGTNYIPD
OrthoDBiEOG091G01BU
PhylomeDBiF5H2F4

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
MF_01576 THF_DHG_CYH, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR036291 NAD(P)-bd_dom_sf
IPR027417 P-loop_NTPase
IPR000672 THF_DH/CycHdrlase
IPR020630 THF_DH/CycHdrlase_cat_dom
IPR020867 THF_DH/CycHdrlase_CS
IPR020631 THF_DH/CycHdrlase_NAD-bd_dom
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
PF00763 THF_DHG_CYH, 1 hit
PF02882 THF_DHG_CYH_C, 1 hit
PRINTSiPR00085 THFDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit
PS00766 THF_DHG_CYH_1, 1 hit
PS00767 THF_DHG_CYH_2, 1 hit

Sequencei

Sequence statusi: Complete.

F5H2F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHRVCRGRS GQGRRRSSVI PWPVPKHVGW VVLLGCGGSG TSILVVSIVG
60 70 80 90 100
SGLIKAMAPA EILNGKEISA QIRARLKNQV TQLKEQVPGF TPRLAILQVG
110 120 130 140 150
NRDDSNLYIN VKLKAAEEIG IKATHIKLPR TTTESEVMKY ITSLNEDSTV
160 170 180 190 200
HGFLVQLPLD SENSINTEEV INAIAPEKDV DGLTSINAGK LARGDLNDCF
210 220 230 240 250
IPCTPKGCLE LIKETGVPIA GRHAVVVGRS KIVGAPMHDL LLWNNATVTT
260 270 280 290 300
CHSKTAHLDE EVNKGDILVV ATGQPEMVKG EWIKPGAIVI DCGINYVPDD
310 320 330 340 350
KKPNGRKVVG DVAYDEAKER ASFITPVPGG VGPMTVAMLM QSTVESAKRF
360 370 380 390 400
LEKFKPGKWM IQYNNLNLKT PVPSDIDISR SCKPKPIGKL AREIGLLSEE
410 420 430 440 450
VELYGETKAK VLLSALERLK HRPDGKYVVV TGITPTPLGE GKSTTTIGLV
460 470 480 490 500
QALGAHLYQN VFACVRQPSQ GPTFGIKGGA AGGGYSQVIP MEEFNLHLTG
510 520 530 540 550
DIHAITAANN LVAAAIDARI FHELTQTDKA LFNRLVPSVN GVRRFSDIQI
560 570 580 590 600
RRLKRLGIEK TDPTTLTDEE INRFARLDID PETITWQRVL DTNDRFLRKI
610 620 630 640 650
TIGQAPTEKG HTRTAQFDIS VASEIMAVLA LTTSLEDMRE RLGKMVVASS
660 670 680 690 700
KKGEPVSAED LGVSGALTVL MKDAIKPNLM QTLEGTPVFV HAGPFANIAH
710 720 730 740 750
GNSSIIADRI ALKLVGPEGF VVTEAGFGAD IGMEKFFNIK CRYSGLCPHV
760 770 780 790 800
VVLVATVRAL KMHGGGPTVT AGLPLPKAYI QENLELVEKG FSNLKKQIEN
810 820 830 840 850
ARMFGIPVVV AVNAFKTDTE SELDLISRLS REHGAFDAVK CTHWAEGGKG
860 870 880 890 900
ALALAQAVQR AAQAPSSFQL LYDLKLPVED KIRIIAQKIY GADDIELLPE
910 920 930 940 950
AQHKAEVYTK QGFGNLPICM AKTHLSLSHN PEQKGVPTGF ILPIRDIRAS
960 970 980 990 1000
VGAGFLYPLV GTITIHLQEA TLKVWPVSIQ AHWELGSISK PREVSPCPED
1010 1020
LKLIVGVSPE VIFSLNSHHV
Length:1,020
Mass (Da):110,613
Last modified:June 28, 2011 - v1
Checksum:iC4B137C42AC01F89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122035 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000545908; ENSP00000438588; ENSG00000100714
UCSCiuc010aqf.4 human

Similar proteinsi

Entry informationi

Entry nameiF5H2F4_HUMAN
AccessioniPrimary (citable) accession number: F5H2F4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: April 25, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health