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Protein

Matrix metalloproteinase

Gene

MMP17

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotation, Protease
LigandCalciumUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:MMP17Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198598.6.
HGNCiHGNC:7163. MMP17.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198598.

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Proteomic databases

PaxDbiF5H249.
PeptideAtlasiF5H249.
PRIDEiF5H249.

Expressioni

Gene expression databases

BgeeiENSG00000198598.
ExpressionAtlasiF5H249. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati12 – 57HemopexinPROSITE-ProRule annotationAdd BLAST46
Repeati58 – 105HemopexinPROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.

Family and domain databases

CDDicd00094. HX. 1 hit.
Gene3Di2.110.10.10. 1 hit.
InterProiView protein in InterPro
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR028726. MMP17.
PANTHERiPTHR10201:SF194. PTHR10201:SF194. 1 hit.
PfamiView protein in Pfam
PF00045. Hemopexin. 2 hits.
SMARTiView protein in SMART
SM00120. HX. 2 hits.
SUPFAMiSSF50923. SSF50923. 1 hit.
PROSITEiView protein in PROSITE
PS51642. HEMOPEXIN_2. 2 hits.

Sequencei

Sequence statusi: Fragment.

F5H249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRFWRGLPL HLDSVDAVYE RTSDHKIVFF KGDRYWVFKD NNVEEGYPRP
60 70 80 90 100
VSDFSLPPGG IDAAFSWAHN DRTYFFKDQL YWRYDDHTRH MDPGYPAQSP
110
LWRGVPSTLD DAMRWSDG
Length:118
Mass (Da):14,029
Last modified:June 28, 2011 - v1
Checksum:iCB1244E48E333957
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei118Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131009 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000542648; ENSP00000439542; ENSG00000198598.
UCSCiuc058vgz.1. human.

Similar proteinsi

Entry informationi

Entry nameiF5H249_HUMAN
AccessioniPrimary (citable) accession number: F5H249
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 27, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported