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Protein

Matrix metalloproteinase

Gene

MMP17

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Protein has several cofactor binding sites:
  • Ca2+UniRule annotation
  • Zn2+UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, MetalloproteaseUniRule annotation, Protease
LigandCalciumUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix metalloproteinaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:MMP17Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:7163. MMP17.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198598.

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Proteomic databases

PaxDbiF5H209.
PeptideAtlasiF5H209.

Expressioni

Gene expression databases

BgeeiENSG00000198598.
ExpressionAtlasiF5H209. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati16 – 63HemopexinPROSITE-ProRule annotationAdd BLAST48

Sequence similaritiesi

Belongs to the peptidase M10A family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00760000118870.

Family and domain databases

Gene3Di2.110.10.10. 1 hit.
InterProiView protein in InterPro
IPR000585. Hemopexin-like_dom.
IPR018487. Hemopexin-like_repeat.
IPR028726. MMP17.
PANTHERiPTHR10201:SF194. PTHR10201:SF194. 1 hit.
PfamiView protein in Pfam
PF00045. Hemopexin. 1 hit.
SMARTiView protein in SMART
SM00120. HX. 1 hit.
SUPFAMiSSF50923. SSF50923. 1 hit.
PROSITEiView protein in PROSITE
PS51642. HEMOPEXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F5H209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGYPAQSP LWRGVPSTLD DAMRWSDGAS YFFRGQEYWK VLDGELEVAP
60 70 80 90 100
GYPQSTARDW LVCGDSQADG SVAAGVDAAE GPRAPPGQHD QSRSEDGYEV
110 120 130 140
CSCTSGASSP PGAPGPLVAA TMLLLLPPLS PGALWTAAQA LTL
Length:143
Mass (Da):14,923
Last modified:June 28, 2011 - v1
Checksum:i025236B3E4556008
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC131009 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000535004; ENSP00000445620; ENSG00000198598.
UCSCiuc058vha.1. human.

Similar proteinsi

Entry informationi

Entry nameiF5H209_HUMAN
AccessioniPrimary (citable) accession number: F5H209
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: August 30, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported