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Protein
Submitted name:

Tyrosine-protein phosphatase non-receptor type 6

Gene

PTPN6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiF5H1Z8.

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine-protein phosphatase non-receptor type 6Imported
Gene namesi
Name:PTPN6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9658. PTPN6.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111679.

PTM / Processingi

Proteomic databases

PaxDbiF5H1Z8.
PeptideAtlasiF5H1Z8.
PRIDEiF5H1Z8.

Expressioni

Gene expression databases

BgeeiENSG00000111679.
ExpressionAtlasiF5H1Z8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000391592.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 100SH2InterPro annotationAdd BLAST97

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

F5H1Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRWFHRDLS GLDAETLLKG RGVHGSFLAR PSRKNQGDFS LSVRVGDQVT
60 70 80 90 100
HIRIQNSGDF YDLYGGEKFA TLTELVEYYT QQQGVLQDRD GTIIHLKYPL
110 120 130 140 150
NCSDPTSERW YHGHMSGGQA ETLLQAPRSG SPTSRSCARV DATQWVVWRP
Length:150
Mass (Da):16,969
Last modified:October 5, 2016 - v8
Checksum:i89C6173EA8EA5A65
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei150Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000541698; ENSP00000445646; ENSG00000111679.
UCSCiuc058koo.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA. No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000391592.

Proteomic databases

PaxDbiF5H1Z8.
PeptideAtlasiF5H1Z8.
PRIDEiF5H1Z8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541698; ENSP00000445646; ENSG00000111679.
UCSCiuc058koo.1. human.

Organism-specific databases

HGNCiHGNC:9658. PTPN6.
OpenTargetsiENSG00000111679.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0790. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.

Enzyme and pathway databases

SignaLinkiF5H1Z8.

Miscellaneous databases

ChiTaRSiPTPN6. human.

Gene expression databases

BgeeiENSG00000111679.
ExpressionAtlasiF5H1Z8. baseline and differential.

Family and domain databases

Gene3Di3.30.505.10. 2 hits.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF5H1Z8_HUMAN
AccessioniPrimary (citable) accession number: F5H1Z8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 5, 2016
Last modified: November 30, 2016
This is version 44 of the entry and version 8 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.