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Protein

V-type proton ATPase subunit a

Gene

ATP6V0A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:ATP6V0A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:865. ATP6V0A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei47 – 71HelicalUniRule annotationAdd BLAST25
Transmembranei91 – 110HelicalUniRule annotationAdd BLAST20
Transmembranei187 – 208HelicalUniRule annotationAdd BLAST22
Transmembranei214 – 238HelicalUniRule annotationAdd BLAST25
Transmembranei279 – 303HelicalUniRule annotationAdd BLAST25
Transmembranei387 – 410HelicalUniRule annotationAdd BLAST24
Transmembranei416 – 439HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000033627.

PTM / Processingi

Proteomic databases

MaxQBiF5H1T6.
PaxDbiF5H1T6.
PeptideAtlasiF5H1T6.
PRIDEiF5H1T6.

Expressioni

Gene expression databases

BgeeiENSG00000033627.
ExpressionAtlasiF5H1T6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliF5H1T6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2189. Eukaryota.
COG1269. LUCA.
GeneTreeiENSGT00390000004941.

Family and domain databases

InterProiView protein in InterPro
IPR002490. V-ATPase_116kDa_su.
PANTHERiPTHR11629. PTHR11629. 1 hit.
PfamiView protein in Pfam
PF01496. V_ATPase_I. 1 hit.

Sequencei

Sequence statusi: Complete.

F5H1T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTNQTPPTY NKTNKFTYGF QNIVDAYGIG TYREINPAPY TIITFPFLFA
60 70 80 90 100
VMFGDFGHGI LMTLFAVWMV LRESRILSQK NENEMFSTVF SGRYIILLMG
110 120 130 140 150
VFSMYTGLIY NDCFSKSLNI FGSSWSVRPM FTYNWTEETL RGNPVLQLNP
160 170 180 190 200
ALPGVFGGPY PFGIDPIWNI ATNKLTFLNS FKMKMSVILG IIHMLFGVSL
210 220 230 240 250
SLFNHIYFKK PLNIYFGFIP EIIFMTSLFG YLVILIFYKW TAYDAHTSEN
260 270 280 290 300
APSLLIHFIN MFLFSYPESG YSMLYSGQKG IQCFLVVVAL LCVPWMLLFK
310 320 330 340 350
PLVLRRQYLR RKHLGTLNFG GIRVGNGPTE EDAEIIQHDQ LSTHSEDADE
360 370 380 390 400
PSEDEVFDFG DTMVHQAIHT IEYCLGCISN TASYLRLWAL SLAHAQLSEV
410 420 430 440 450
LWTMVIHIGL SVKSLAGGLV LFFFFTAFAT LTVAILLIME GLSAFLHALR
460 470 480
LHWVEFQNKF YSGTGFKFLP FSFEHIREGK FEE
Length:483
Mass (Da):55,233
Last modified:June 28, 2011 - v1
Checksum:i3FD441FC9C6B9A1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067852 Genomic DNA. No translation available.
AC107993 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000544137; ENSP00000446377; ENSG00000033627.
UCSCiuc010cyg.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiF5H1T6_HUMAN
AccessioniPrimary (citable) accession number: F5H1T6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 5, 2017
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported